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Sodium Hyaluronate Dosage

Medically reviewed by Last updated on Mar 17, 2021.

Applies to the following strengths: 10 mg/mL; 20 mg/mL; 8.4 mg/mL

Usual Adult Dose for Osteoarthritis

Hyalgan: 2 mL by intra-articular injection into the knee once weekly for 5 weeks
Supartz: 2.5 mL by intra-articular injection into the knee once weekly for 5 weeks

Use: For the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative non-pharmacologic therapy and simple analgesics (e.g., acetaminophen)

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available


-Hypersensitivity to the active component or any of the ingredients
-Intra-articular injections are contraindicated in skin infections or disease in the area of the injection site to reduce the potential for developing septic arthritis

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.


Data not available

Other Comments

Storage requirements:
-Store in original packaging (protected from light) below 77F (25C).
-Do not freeze.

-This drug is only for injection into the knee, performed by a doctor or other qualified health care professional.
-This drug has not been tested to show pain relief in joints other than the knee.
-This drug has not been tested to show better pain relief when combined with other injected medicines.
-The effectiveness of a single treatment cycle of less than 3 injections has not been established.

Patient advice:
-Tell your doctor if you are allergic to products from birds such as feathers, eggs, and poultry.
-Tell your doctor if you have significant swelling or blood clots in the leg.
-This drug has not been tested in pregnant women, or women who are nursing. You should tell your doctor if you think you are pregnant, or if you are nursing a child.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.