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Sodium hyaluronate and Back Pain: What Users Say

Brand names: Euflexxa, Durolane, Gelsyn-3, Hyalgan, Supartz, Supartz FX

Back pain: mentioned by 11 users (1.7%)

Based on user experiences from 652 Sodium hyaluronate reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

pain 35.1%
swelling 10.0%
severe pain 6.0%
discomfort 4.6%
headaches 3.8%
stiffness 3.2%
nausea 2.3%
back pain 1.7%
soreness 1.4%
dizziness 1.1%

Reviews for Sodium hyaluronate

Commonly mentioned side effects
  • bre...
  • Taken for 1 to 6 months
  • June 1, 2023

For Osteoarthritis "I received the Gelsyn-3 knee injections, one each week for 3 weeks. The first injection, my knees were sore, but I really didn't feel much different as my knees still hurt as before. I received the second injection, and that next day I began having more pain than I had ever had. I started hurting behind my left knee, which had never hurt me before. I felt fatigued and had leg and thigh pain at night that I couldn't sleep most nights. I really didn't want to get the third shot but was advised by my doctor that after the third shot, I should start feeling some relief. I told him my knees hurt worse than they did before, but he said that should go away, so I got the third injection. A few days after the third injection, my legs started hurting all over, especially at night. I had a headache, my lower back hurt, and I was just sick all over. This went on for several weeks. It's been 6 weeks after the injections, and my knees are no better. I would never do this again, NEVER!"

1 / 10
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21 Report
  • BPa...
  • Taken for less than 1 month
  • June 8, 2019

For Osteoarthritis "I had my 3rd injection of Gelsyn-3 this week. Two days after, I started experiencing severe lower back pain and also severe muscle pain in both of my thighs. I hope this doesn’t last too much longer, it is one of the side effects. So far, no relief for my knee pain."

3 / 10
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44 Report
  • Sug...
  • Taken for less than 1 month
  • February 26, 2021

For Osteoarthritis "Had the entire series of Gelsyn. My knee feels worse than before. I can barely walk or put any weight on the knee. I have had low back pain, and I've also had a cramping sensation and spasm in the knee. The pain is excruciating. I'm very disappointed, as I'm not wanting surgery. I personally would not recommend this drug."

1 / 10
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27 Report

See also:

  • 101...
  • December 7, 2015

For Osteoarthritis "After years of pain, I decided to get relief with 'Euflexxa' shots. Worst decision I ever made. I got my first shot on 11-4-15, and I have been sick with a fever-99.3 - 101.5 since then, and it is now 12-6-15. I went back to the doctor who gave me the 2 shots for the 3rd shot on 11-18-15 and showed him the swelling in my neck, along with the constant fever, muscle spasms, back and shoulder pain, headaches, joint pain, feeling weak, and constant terrible neck pain, so I can't drive. The doctor said that I have had an adverse reaction to 'Euflexxa' as after the first 2 shots my fever spiked within 24 hours. He wouldn't give me the 3rd shot, and told me to apply ice on my neck swelling and allow the 'Euflexxa' to wear off. Horrible nightmare-never again."

1 / 10
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39 Report
  • Mag...
  • August 6, 2019

For Osteoarthritis "I had a total knee replacement, right knee, 15 months ago with terrible results. Now my left knee is painful due to arthritis. Dr. will not do another knee replacement due to the results of the first one. Suggested Euflexxa series of three shots. They were somewhat painful during injections. After the first two shots, I felt a little better. Now, one week after the third shot, I have terrible muscle spasms in my back and sciatica on both sides. Painful standing for any amount of time. Had a bad headache for two days. Taking Tramadol for the pain. I am allergic to cortisone, so that is not an option. I had torn meniscus repair in both knees years ago. Will not do any more Euflexxa shots as I probably have sensitivity to that as well. Glad it worked for some of you, but there is no way to know if it will work, it is a chance you take."

3 / 10
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24 Report

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  • Ser...
  • February 8, 2017

For Osteoarthritis "Don't bother wasting your time with Euflexxa. I have been diagnosed with moderate osteoarthritis, and Euflexxa only made my condition worse. Now I am stuck with a sore back, I can hardly bend over, my limbs have no flexibility and are sore as heck. I don't get it. The treatment did not even come close to doing what it was described as. My doctor told me that the fluid only stays in your knee about two days, and then it is gone. It is not described that way on the Euflexxa website. It says it hardens into a gel, then forms a cushion between your bones. My experience is that this is NOT true. And how much am I paying for this??? Don't bother spending your money on Euflexxa. Your money is better spent on a partial or full knee replacement."

1 / 10
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26 Report
  • Dai...
  • Taken for less than 1 month
  • June 3, 2022

For Osteoarthritis "I had Durolane injections in both knees ten days ago. My side effects included nausea, headache, back pain, tingling. Now my knees ache and burn so badly every movement is excruciating. I can barely get around the house. At seventy-two years old, this is the WORST decision I’ve ever made. PLEASE, if you are thinking about getting Durolane injections, don’t. Once it’s done, there’s no going back."

1 / 10
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11 Report
  • gin...
  • Taken for less than 1 month
  • June 5, 2022

For Osteoarthritis "I am two weeks out following my third shot of Gelsyn-3, and I have had a slight pain improvement, but the bone-on-bone pain still keeps me from walking any sort of distance, like through a grocery store. I had a headache and back pain at first, but that seems to be subsiding. I am hoping in two more weeks, I will have greater mobility with less pain, but most of these reviews seem to be of a negative result, so I am discouraged. I was hoping these injections would save me from a replacement, but so far, I have not had full pain or mobility relief."

5 / 10
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9 Report
  • Ben...
  • Taken for less than 1 month
  • August 12, 2022

For Osteoarthritis "My provider injected at only one site, not several. He claimed I only could get 1 injection, not the 3 recommended. That’s for the best because I am having unbearable pain in my thighs, they feel overinflated footballs. So much product was injected that my pelvis was pushed up. Now I have pinched nerves constantly pulsing in my back and lower back pain. I have been falling because my knees are so swollen and tight, like cement. I had Suarez many years ago and can 100% recommend it. There are too many negative reviews on this page. My advice is to stay away from Gelsyn-3. Please take this seriously or you may deeply regret having your mobility and your life taken from you."

1 / 10
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10 Report
  • San...
  • December 29, 2016

For Osteoarthritis "Was told I needed a knee replacement on my right knee, not bone on bone yet but close. Had my first injection 12/13/16. Injection was not painful because it was injected slowly as it is thick, only felt pressure as it was almost done. Second injection was a horror as the person injecting just slammed the whole thing in, and I was in severe pain and could hardly walk out of the office. I just had my third injection yesterday, and the person who gave me the first injection did it with no pain. I have felt no real pain in my knee since the first injection so far. Dr. said there are 6cc's of fluid that is now in the joint, so it may feel like you're walking on a bubble. My issue is I'm having very bad back pain, which I'm not sure if that is related to the injection or not."

9 / 10
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11 Report
  • Car...
  • Taken for 1 to 6 months
  • November 17, 2021

For Osteoarthritis "I had the injection on July 26, 2021, and I developed a torn meniscus. I didn't have an injury before the injection that required surgery. I do not recommend this injection to anyone. It is so concentrated that it doesn't stay in the kneecap, it spreads through the leg. Causing pressure, numbness, itching, weakness of joints, tingling in feet, and back and shoulder pains. I want this stuff out of my body, but the doctor that administered the drug is ignoring me."

1 / 10
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4 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.