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Euflexxa User Reviews & Ratings (Page 4)

Euflexxa has an average rating of 6.1 out of 10 from a total of 261 reviews on Drugs.com. 54% of reviewers reported a positive experience, while 35% reported a negative experience.

Reviews for Euflexxa

Commonly mentioned side effects
  • Eig...
  • March 20, 2017

For Osteoarthritis "Wonderful! I was told 5 years ago that I needed both knees replaced... not yet bone on bone. Hearing mixed results from friends who had replacements, I decided to wait until pain was unbearable. Started getting Euflexxa injections three years ago. Not totally pain-free, but so good I'm not even considering replacement at this time. Wow!"

9 / 10
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36 Report
  • Exh...
  • Taken for less than 1 month
  • June 7, 2018

For Osteoarthritis "I’m a 43-year-old female with osteoarthritis. I’ve had my third Euflexxa injection today. I have not gotten any better, if anything, I'm worse off. I've been off work for weeks on FMLA leave (Family and Medical Leave Act). I pray this takes effect soon. I’ve always been a go-getter, and I feel so trapped having to walk slow, deal with the pain, and that could be unbearable at times. I take nothing for pain, the doctor gives me nothing for pain. I can’t take NSAIDs due to my G.I. issues, and my blood pressure is high at nighttime. It’s horrible. I’m just trying to find a way to live with this the best way I know how. I’ll take any suggestions. I’m ready to get back to work, I wear a brace when I am at work. I need my pain controlled before my blood pressure becomes a REAL problem."

2 / 10
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30 Report
  • Mom...
  • April 2, 2008

For Osteoarthritis "Received my first injection in my 'worse' knee this morning. After the initial pain of the injection, within a few hours, there was noticeable relief of pain, so much so that climbing stairs was a breeze - for that leg, anyway. Can't wait to finish the cycle (a total of 3 injections) and then have the 'better' knee treated, too."

10 / 10
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65 Report
  • Pgh...
  • Taken for less than 1 month
  • June 17, 2016

For Osteoarthritis "I completed all 3 shots about 2 weeks ago. My knee is feeling so much better. I don't need my cane anymore. I went back to exercise class this week and can do the standing exercises again. Very impressed!"

10 / 10
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36 Report
  • 101...
  • December 7, 2015

For Osteoarthritis "After years of pain, I decided to get relief with 'Euflexxa' shots. Worst decision I ever made. I got my first shot on 11-4-15, and I have been sick with a fever-99.3 - 101.5 since then, and it is now 12-6-15. I went back to the doctor who gave me the 2 shots for the 3rd shot on 11-18-15 and showed him the swelling in my neck, along with the constant fever, muscle spasms, back and shoulder pain, headaches, joint pain, feeling weak, and constant terrible neck pain, so I can't drive. The doctor said that I have had an adverse reaction to 'Euflexxa' as after the first 2 shots my fever spiked within 24 hours. He wouldn't give me the 3rd shot, and told me to apply ice on my neck swelling and allow the 'Euflexxa' to wear off. Horrible nightmare-never again."

1 / 10
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39 Report

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  • Don...
  • August 18, 2016

For Osteoarthritis "I'm going on two years now with almost no pain. I see stairs and try to figure out where the elevators were, curbs were also a challenge. I never experienced pain during injections and noticed immediate relief, even walking back to my car. By the 3rd injection, I was thrilled! So happy with this."

10 / 10
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34 Report
  • cam...
  • Taken for less than 1 month
  • December 11, 2016

For Osteoarthritis "I have never experienced such pain or debilitation in all of my life. It has been three weeks, and I am still limping. I cannot sit, stand, or walk for any length of time. Had I known this level of pain was a possible side effect, I would not have used the drug. This goes beyond the usual injection site redness, this goes into swelling of the knee joint, pain up and down the leg, as well as the leg being feverish. If anyone ever asks me about this or any other type of injection using this formula, I will tell them to really make sure there aren't other options before risking this kind of pain."

1 / 10
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35 Report
  • Kim...
  • June 17, 2011

For Osteoarthritis "I received my 1st Euflexxa injection today in my right knee. I'm only 30, but have had knee problems since I was 9. I'm now bone on bone in that knee, and my left isn't far behind. I can't have my Fulkerson until the last shot, 6 weeks, so it's either do the shots or live with my pain. I must say, this 1st shot has left me in a world of hurt. The shot itself was pain-free (having used ethyl chloride numbing spray), and I walked out perfectly fine. Here it is, 8 hours later, and my knee hurts worse than it has in a while. I hope after I hit that 2-day mark, it will get better. Only time will tell, though. I just wish they'd tell you the '48-hour pain' could be this severe."

5 / 10
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51 Report
  • Sus...
  • January 13, 2016

For Osteoarthritis "First injection, almost fainted, severe headache and severe blood pressure increase. Second injection, severe headache and blood pressure increase, went to ER. I've had to go on blood pressure meds after injections four months ago. My BP was normal to low prior to injections. I refused third knee injection."

1 / 10
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40 Report
  • Hap...
  • June 8, 2016

For Osteoarthritis "I have been in such severe pain with my knee for 1 year. I went to Arizona Sports Medicine in Scottsdale and had it drained 3 times, 4 cortizone shots within 6 months and didn't help. Then I went to Dr. Charles S. Peterson at Arizona Sports Medicine in Mesa. He is the best doctor I have ever been to. He listens to what is going on with you. He suggested I get the Euflexxa series of 3 shots. I was excited and ready to get my first shot. I got the first shot done. He puts a typical numbing on the surface, then gives me the shot. Oh my, it hurt only when he released the liquid from the syringe, and I could barely walk out, I was in tears. It calmed down. Then the second shot felt great, then I will get a third shot. It really works, I'm on my feet."

9 / 10
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34 Report
  • Ric...
  • February 6, 2020

For Osteoarthritis "I received the first injection of Euflexxa only yesterday. I am in excruciating pain radiating down to my ankle. I can walk without pain now. I am hopeful, but if this doesn't subside, I am in trouble. 51-year-old avid skier, hiker, biker, and I am stuck on the couch. I will update, but as of now, I am very nervous this has made things worse."

1 / 10
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29 Report
  • Mo1...
  • February 21, 2017

For Osteoarthritis "Had a Synvisc One shot about 2 years ago and experienced ZERO relief, so I almost gave up on these types of injections. My right knee was hurting so bad that I had to reconsider. My new doctor told me that he has had the best experience with Euflexxa. This medication is a once-per-week injection for 3 weeks. I go in to get my first injection, and the doctor told me to not expect much, however, a day later, I could 100% feel a significant improvement in my knee. While my knee will never be 100%, I rate this product so high because my knee pain has reduced at least 60-70%, which to me is a miracle. I have 2 more injections to go, and on my last injection, they will also be doing PRP therapy to my knee."

10 / 10
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31 Report
  • Nan...
  • Taken for less than 1 month
  • May 19, 2019

For Osteoarthritis "I just finished my 3rd set of Euflexxa bilateral knee injections. Wasn’t sure about them, but I now see a difference in my osteoarthritis in less than a week later. Hoping they continue to improve. My Dr. said the relief would be gradual. Trying to avoid total knee replacement."

9 / 10
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  • Mag...
  • August 6, 2019

For Osteoarthritis "I had a total knee replacement, right knee, 15 months ago with terrible results. Now my left knee is painful due to arthritis. Dr. will not do another knee replacement due to the results of the first one. Suggested Euflexxa series of three shots. They were somewhat painful during injections. After the first two shots, I felt a little better. Now, one week after the third shot, I have terrible muscle spasms in my back and sciatica on both sides. Painful standing for any amount of time. Had a bad headache for two days. Taking Tramadol for the pain. I am allergic to cortisone, so that is not an option. I had torn meniscus repair in both knees years ago. Will not do any more Euflexxa shots as I probably have sensitivity to that as well. Glad it worked for some of you, but there is no way to know if it will work, it is a chance you take."

3 / 10
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24 Report
  • Anonymous
  • November 2, 2011

For Osteoarthritis "I am in the middle of my second course of Euflexxa. I had it six months ago, and the pain relief was significant. One thing to note is that your doctor should place the injection exactly where your arthritis is. No improvement could mean he or she is not doing the injection in the right place. Another thing to note is that your activity tolerance in the first 48 hours after a Euflexxa shot can vary tremendously. I think most doctors use local anesthetic, and last shot I 'felt fine' and was walking around and using short flights of stairs too much, resulting in severe pain that night (Percocet needed) and still a lot of pain the next day. The third day I was fine, though. Today I got a shot, and I am taking it easy to avoid pain."

9 / 10
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45 Report
  • Gul...
  • July 27, 2017

For Osteoarthritis "I am a certified spin instructor, and I currently take and/or teach 6 classes per week. Have done so for years, and before that, I was a high-impact aerobics instructor, which is where I probably did my damage. I also ride my road bike approx. 50 miles a week. I suffer from OA and a torn meniscus (2 places) in my left knee only. I had shot #1 and taught the same day. I immediately noticed a slight improvement with a feeling of increased stability. I no longer take ibuprofen as needed, which was usually only before spin classes. I have #2 tomorrow, so I'm hoping for more improvement. By the way, the shot was easier than the cortisone shot."

9 / 10
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31 Report
  • Ex ...
  • November 6, 2019

For Osteoarthritis "I had knee pain with walking several miles. 30 years of running took a toll, and on doctor's orders, I gave up running to avoid knee replacement before 60. I ride a bike up to 80 miles a day with discomfort. After three shots over three weeks, I have minimal discomfort and completed 500 miles in one week without any issues. No problems from the injections. It has been 6 months, and my knee is starting to get more tender again."

8 / 10
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24 Report
  • Old...
  • Taken for 6 months to 1 year
  • June 6, 2015

For Osteoarthritis "So I had my first injections one year ago, worked great. Be sure you know what you're paying and when (so there is no sticker shock). My doc suggested a one-time injection this time around, so I'm going with his recommendation (they charge per visit for X3). I would like to share one knee, torn meniscus one week (after year had expired), waited two weeks for recoup, other knee went after the two weeks. So I'm waiting for pre-authorization for the shots for both knees. Down the road, I am probably looking at knee replacement, but don't want to get cut until all other options are exhausted."

10 / 10
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40 Report
  • Cru...
  • Taken for less than 1 month
  • July 6, 2017

For Osteoarthritis "My knees were in so much pain that my doctor recommended I have Euflexxa shots in both of my knees. I had my last injection, number 3, on June 16th, and I have no improvement in my knees. This was very costly, which I really could not afford, and my knees are in just as much pain now as they were before I had the injections."

1 / 10
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29 Report
  • old...
  • July 17, 2016

For Osteoarthritis "Was having severe leg pain with 2nd shot, but Dr. gave me 3rd shot without listening to my concerns. 3rd shot disabled my walking for 3 months, lost energy to where I had to rest after taking a shower, unable to walk without a cane or assistance for 3 months, could not put a sock on my foot, as bending at all caused unbearable pain in the groin. Difficulty sleeping with pain without sleep aid. Would never want to experience that again. But, after 6 months, I am able to walk 2 miles daily without knee hurting at all. Primary doc said I had an allergic reaction to the medication."

3 / 10
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  • aly...
  • December 3, 2016

For Osteoarthritis "Despite the reviews I read about Euflexxa, I received my first injection yesterday. I was scared at first, but I did it anyway. I have an excellent doctor. He explained everything before the injections. He said I would feel the initial stick and then pressure from the medicine going in. He also said I might have swelling and pain at the injection site the next day. I am pleased to report not only did I not feel the pressure, I did not have any pain or swelling at the injection site the next day. When I woke up, I had zero pain in my knee. I am glad I decided to get this injection. I can't wait to see what the second injection will make me feel like."

9 / 10
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30 Report
  • A y...
  • Taken for 2 to 5 years
  • February 27, 2014

For Osteoarthritis "I am 28 and have done 4-5 rounds of Euflexxa. So far, it does help decrease pain levels and increase activity. However, this last round, in December, was extremely painful. I am hoping it was weather-related, and not related to the medicine or to my knee getting worse."

8 / 10
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38 Report
  • Haz...
  • Taken for less than 1 month
  • November 27, 2018

For Osteoarthritis "I moved to a new state, so I had to change doctors. I previously was getting Orthovisc shots, a series of 4, which worked great for me! But for some reason, the new doctor could not get Orthovisc and suggested Euflexxa. I had the three Euflexxa injections in October, and now two weeks after receiving them, I am experiencing locking knee and knee buckling while walking. I may need a steroid injection now. I usually walk 2 miles a day. I’m going to fight for what worked for me, so disappointed!"

3 / 10
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24 Report
  • Mar...
  • May 17, 2021

For Osteoarthritis "In December 2020, my orthopedic doctor convinced me to try Euflexxa instead of a knee replacement. By January, I knew something was wrong; my knees were worse. I started to have joint pain in my wrists and shoulders. The doctor said it could take 6 weeks, but by then, my ankles and both feet were painful. I was mostly bedridden. When I saw him in February, he did blood work, saw my elevated inflammation numbers, and told me I must have lupus. He referred me to a rheumatologist. They both decided that I have polymyalgia rheumatica but can't say that for certain. They say it was dormant inside my body, and the reaction to the Euflexxa activated it. Neither believe I have had a bad reaction to Euflexxa. I am now on prednisone, have started to slowly taper, but the rheumatologist wants me to start methotrexate in a month. She says this is a permanent condition. I'm 69 years old. I used to make pottery, jewelry, garden, and walk. I still need a knee replacement. I'm looking for a new orthopedic and rheumatologist."

1 / 10
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18 Report
  • Pam...
  • Taken for 1 to 2 years
  • February 24, 2019

For Osteoarthritis "I started experiencing severe pain in my right knee over 1.5 years ago. Doc told me it was moderate OA, and I needed a replacement. He suggested the Euflexxa shots. After the first injection, I had no improvement. After the second injection, pain was markedly reduced, and following the third injection, most pain was gone. It’s time now to treat this knee again along with the left one. Euflexxa has been a great alternative to surgery for me. Hopefully, my insurance still covers it."

9 / 10
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23 Report

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