Euflexxa and Discomfort: What Users Say

• Pai...
• September 24, 2014

For Osteoarthritis "I have received knee shots with Euflexxa, Hyalgan, and Synvisc-One. They all worked well for me. I experienced a little discomfort walking the first 10 minutes after the injections. The Euflexxa felt like WD-40 being sprayed into my knees and worked well. It made my knees feel very lubricated with a bit of a bounce. The others seemed to give a bit more cushion within the knees but with less lubrication. I would recommend Euflexxa to anyone that does not have an allergic reaction to it. Six to twelve months of relief. Greatly satisfied with the product and insurance covered all of the price except the doctor's upfront office visit co-pay."

• Pat...
• Taken for 1 to 6 months
• July 15, 2014

For Osteoarthritis "I am 49, and my right knee has been hurting for a year. MRI showed no tears, just worn cartilage. Steroid shot gave immediate 100% relief from pain, but only for 2 1/2 months. Dr. gave me the series of Euflexa shots, and the shots were not painful... just a little uncomfortable. But I have had very little relief from pain. I am having to take anti-inflammatory and pain pills, but still not much relief. Scared Dr. is going to have to scope it."

• Deb...
• April 16, 2018

For Osteoarthritis "I have had 3 injections of Euflexxa in both knees in a 2-year period. (Each treatment lasted approx 9 mos.) After each injection, I experienced swelling and some discomfort for approx 3 days, but rest and ice took care of it. 2 weeks after the 3rd injection, both times I could return to walking, climbing steps, and riding my bike with no mobility issues or pain. I was so happy to have Euflexxa. Knee replacement is not an option for me due to a blood clotting disorder. Last week, I went in for my 1st injection in year 3. 12 hours after injections, I presented with pain, severe headaches, nausea, fever (100.8-101.6), chills, aches. I contacted the Dr. who said I was having a reaction to Euflexxa. The other 6 injections never did this. I am going on my 4th day of terrible side effects and have no idea how long this will last. The Dr. canceled my future injections. Before you try, question your Dr. on side effects and if you are high risk for an allergic reaction. It is not worth the risk."

• Apa...
• Taken for 1 to 6 months
• May 9, 2023

For Osteoarthritis "Had three sets of injections in both knees in February 2023. Pain and discomfort began in the left knee with each injection. As time passed, knees are worse than prior to injections. Had gel injections about two years ago that worked fine. Wish I had gotten the same type as before. These injections made the condition worse."

• Cub...
• April 26, 2015

For Osteoarthritis "Six weeks since first injections in both knees. Have arthritis and tore the meniscus in both knees last fall. Right knee is 90% bone on bone. First shots did not hurt. Second shots, wow! How I got through it baffles me. Third shot, no pain, just uncomfortable. I'm 47. Noticed a difference after the first week; now we are 5 weeks out, right knee is stiff again and I'm having pain and problems walking. Left knee is hurting, but nothing like before the shots. Am hoping insurance will authorize TKR for the right one. Am basically unable to do anything pain-free."

• Han...
• Taken for 1 to 6 months
• October 17, 2018

For Osteoarthritis "I had a series of 3 injections of Euflexxa by recommendation of my Dr. After the third one, I was told I wouldn’t see any improvement for about a month after. That month came and went, and I was in worse shape than before. I had more pain, stiffness, and general discomfort. These injections were done blind, and when I asked for a follow-up, I was told to seek another Dr. as there was nothing more they could do for me."

• DON...
• Taken for less than 1 month
• September 24, 2021

For Osteoarthritis "Has not worked. Told doctor before getting last injection I was having some discomfort and more leg pain than before. He said after this last injection in a week to 10 days I should start feeling better. Well, I haven't done anything but feel better. I have severe pain in my knee and legs feel like my actual bones are hurting, charley horse light feeling going up and down legs and my feet. My legs, if you can even imagine, are worse since injections. Scared of how long these side effects are going to last."

• Ach...
• Taken for less than 1 month
• July 13, 2016

For Osteoarthritis "I just received my third injection today, and it may be a bit too early to gauge how effective it will be. However, I am pleased to report that, unlike some of the reviewers, I did not find the injections to be painful. I just felt pressure and some discomfort when the fluid was injected, but it was quickly over. And for that, I am thankful. I'll report back after a month or so."