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Euflexxa and Injection Site Pain: What Users Say

Injection site pain: mentioned by 5 users (1.9%)

Based on user experiences from 261 Euflexxa reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

pain 31.8%
swelling 8.4%
severe pain 4.2%
headaches 3.8%
stiffness 3.4%
discomfort 3.1%
injection site pain 1.9%
nausea 1.9%
back pain 1.5%
body aches 1.5%

Reviews for Euflexxa

  • Rae...
  • January 21, 2019

For Osteoarthritis "I’m a 41-year-old with bone-on-bone osteoporosis in both knees. The doctor says my knees look like someone’s twice my age. I had a series of 3 Euflexxa injections in my right knee. They were pretty painful injections, the third being the most painful. But here it is almost 4 weeks since the last injection, and I’m in a worse condition than pre-injections. I was hoping these were going to work, but I’m here to say they’re just a waste of time and money. I do not recommend these injections, and I will not go through the pain again for no result."

1 / 10
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31 Report
  • cam...
  • Taken for less than 1 month
  • December 11, 2016

For Osteoarthritis "I have never experienced such pain or debilitation in all of my life. It has been three weeks, and I am still limping. I cannot sit, stand, or walk for any length of time. Had I known this level of pain was a possible side effect, I would not have used the drug. This goes beyond the usual injection site redness, this goes into swelling of the knee joint, pain up and down the leg, as well as the leg being feverish. If anyone ever asks me about this or any other type of injection using this formula, I will tell them to really make sure there aren't other options before risking this kind of pain."

1 / 10
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35 Report
  • Mag...
  • August 6, 2019

For Osteoarthritis "I had a total knee replacement, right knee, 15 months ago with terrible results. Now my left knee is painful due to arthritis. Dr. will not do another knee replacement due to the results of the first one. Suggested Euflexxa series of three shots. They were somewhat painful during injections. After the first two shots, I felt a little better. Now, one week after the third shot, I have terrible muscle spasms in my back and sciatica on both sides. Painful standing for any amount of time. Had a bad headache for two days. Taking Tramadol for the pain. I am allergic to cortisone, so that is not an option. I had torn meniscus repair in both knees years ago. Will not do any more Euflexxa shots as I probably have sensitivity to that as well. Glad it worked for some of you, but there is no way to know if it will work, it is a chance you take."

3 / 10
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24 Report
  • Den...
  • January 18, 2019

For Osteoarthritis "I am a 32-year-old female, in good physical health, weight, etc. I have severe osteoarthritis, and it is the worst case my orthopedic surgeon said he's ever seen in someone so young. I opted for the Euflexxa injections, 3 rounds, painful injections, supposed to feel a difference in 6 weeks. It has been 3 months, and my knees feel much worse than they did before the injections. I'm sure that has helped other people with knee issues, but for me it has done the opposite. My knees feel more weak than they ever have and are constantly painful."

1 / 10
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20 Report
  • Rae...
  • Taken for less than 1 month
  • December 21, 2020

For Osteoarthritis "I received my first injection, and for me, it was extremely painful during the injection, to the point that I wasn't sure I could go through with a second and third. I did experience mild discomfort afterwards, however, that subsided in about a day. In the following week, my knee felt much better after my first injection, with much less aching and pain. I have my second and third to go and am moving forward with the injections, as I feel the benefits outweigh the painful injection experience."

8 / 10
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12 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.