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Rybelsus User Reviews & Ratings (Page 3)

Rybelsus has an average rating of 6.4 out of 10 from a total of 283 reviews on Drugs.com. 48% of reviewers reported a positive experience, while 24% reported a negative experience.

Reviews for Rybelsus

Commonly mentioned side effects
  • Amr...
  • Taken for less than 1 month
  • December 20, 2023

"I am hypothyroid and have difficulty losing weight. I was overweight as well. I was prescribed Rybelsus by my doctor. From the first 3 mg onwards, it was extremely effective. I felt an immediate lowering of appetite. I felt very sleepy the first three weeks of the 3 mg dose, but then that quickly settled. My energy levels are now stable. I work out every day, a combination of cardio and weights. I have lost 7 pounds in 25 days. I am still on the 3 mg dose. My appetite is extremely suppressed, and I can go long periods without food. I have no dizziness or anxiety. I will stay on this since I have another 8 pounds to lose. This low dose worked very well for me."

10 / 10
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  • Gra...
  • Taken for 1 to 6 months
  • August 26, 2022

For Type 2 Diabetes "I have pre-diabetes and obesity and started on the 3 mg dose for the first month and then moved to 7 mg. I was very nauseous and found I could eat very little. I had no appetite. Great for weight loss, but I felt really bad. Maybe two weeks into the 7 mg dose, it was a little better. Then the doctor wanted me to move to 14 mg. I don't like to throw up, and it became too much for me to tolerate. I asked to go back down to the 7 mg dose and have done fine on that ever since. Definitely still keeps appetite in check. Five months in, and I’ve lost 35 pounds. Also showing improvement in my blood sugar levels."

8 / 10
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25 Report
  • Tal...
  • Taken for 6 months to 1 year
  • June 9, 2020

For Type 2 Diabetes "I've been on Rybelsus for 7 months, my starting dose was 3 mg, then to 7 mg. After taking 7 mg for 4 months, my blood sugar began rising higher. I was following a proper diet, so not sure why this happened. Then went to 14 mg, and my blood sugars did great again for 3-4 months and did great, but now blood sugar is rising. Had nauseousness so bad at the start of each new dose increase, my Dr. gave me nausea medication that helped. I've lost 30#. Afraid at this point I'll have to stop and go to insulin. My A1C has gone down, but not enough. Disappointed. Wish Rybelsus would continue to work for me."

8 / 10
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40 Report

Frequently asked questions

  • Zul...
  • Taken for 6 months to 1 year
  • October 21, 2022

For Type 2 Diabetes "I used Rybelsus for 6+ months. I had no problem adjusting to the medication; the 3-, 7-, and 14-mg steps worked for me just great. I didn’t care for how it had to be taken, first thing in the morning, and then wait half an hour before having breakfast or coffee. If it had been effective for me, I could’ve lived with that, though. Over 6+ months, it had no effect on my blood sugar. The reason I got off it was that my pharmacy didn’t have it available for an immediate refill, and I had to wait three days to get it. During those three days, I felt like a veil lifted: it was kind of like “coming to” myself and saying, “Oh! There you are! Where have you been?” I seemed to be in kind of a fog while I was taking Rybelsus and doing absolutely nothing. I was scared to resume taking the medication because I didn’t want to fall into that state again and not even realize it."

1 / 10
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26 Report
  • TN ...
  • Taken for 1 to 6 months
  • October 5, 2020

For Type 2 Diabetes "I've been taking Rybelsus, along with metformin and Farxiga, for over 3 months. I had some minor diarrhea/constipation with the 3 mg that worked itself out quickly, but I lost over 5 lbs and A1C went down over 1 pt (8.3 to 7.2). Just started the 7 mg dose 5 days ago. So far, the diarrhea is a lot worse, and I'm having a lot of dizziness/nausea/fatigue/headaches, but I'm hoping it'll stop soon. I seem to start feeling worse about 5-6 hrs after taking the pill, so I'm sick in bed for hours in the afternoon and evening lately. Not good, as I'm a disabled housewife with two special needs adult children who depend on me. Not sure how someone who works a 9 to 5 job would be able to handle this transition period. If it doesn't sort itself out within a couple of weeks, I'll call my doctor. One tip: keep some saltine crackers and eat a few every hour or so. I know, against diabetic diet, but that and plenty of water help the nausea."

8 / 10
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  • ryb...
  • Taken for 2 to 5 years
  • March 20, 2024

For Type 2 Diabetes "I have been taking Rybelsus for several years now. Before Rybelsus, I was taking Victoza. I have type 2 diabetes and both of these drugs have been complete game changers in my life. My A1c is now below 6 (usually 5.6 or 5.7), my weight is under control, and all my lab results are excellent. But these drugs do cause digestive issues that can be hard to deal with. Intestinal pain (sometimes in the middle of the night), constipation and diarrhea. It's almost like I have IBS and sometimes the side effects are overwhelming for a short amount of time. For me, the positive effects for my health outweigh the side effects."

8 / 10
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  • Ann...
  • Taken for 1 to 6 months
  • March 23, 2025

For Type 2 Diabetes "I have Type 2 diabetes. I have been on this medication for about 5 months and have had significant improvement in my A1C. I started at 7.2 with an average blood sugar of 147. After 3 months, my doctor was well pleased my A1C had dropped to 5.2 and average BS 116."

10 / 10
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2 Report

More FAQ

  • Ann...
  • Taken for 1 to 6 months
  • March 23, 2025

For Type 2 Diabetes "I have type 2 diabetes. I have been on this medication for about 5 months and have had significant improvement in my A1C. I started at 7.2 with an average blood sugar of 147. After 3 months, my doctor was well pleased my A1C had dropped to 5.2 and average BS 116. I do have a slight issue of dizziness when standing up. Not sure if the cause could be blood sugar drops. I have a family history of diabetes and understand the damage it does to your body. I was on metformin for years and my A1C was never below 6.2. I stopped taking it after reading such bad reviews and would never take it again. I have been able to mostly control my levels with diet and moderate exercise by staying active. Currently 71 and have developed a huge sweet tooth. Sugar level was in the high 140s, so I knew I had to do something. My age goal is 110, lol, so time to get healthier. I have lost about 10 pounds in a good way. My decreased appetite has helped me control the food binges."

10 / 10
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2 Report
  • MDG...
  • Taken for less than 1 month
  • August 8, 2020

For Type 2 Diabetes "First, I started on Rybelsus, the 3mg dose, my blood sugar went up over 200. I stopped on the third day, went back to my old meds, and my levels returned to normal. No nausea, no diarrhea, no side effects of any kind. (I did follow the directions to take it first thing on an empty stomach and not eat for thirty minutes.) Dr. switched me to the 7mg dose, so far my blood sugar is running higher than my old meds. I am on day four, so I want to give it plenty of time. I do notice a lack of appetite. At this point, I am not impressed, but I am willing to give it more time before throwing in the towel."

5 / 10
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36 Report
  • Geo...
  • Taken for 1 to 6 months
  • December 14, 2023

For Type 2 Diabetes "I'm 75, 180 lbs. I was diagnosed with T2D 10 years ago. My A1C was 9.2. I was put on Metformin 2000mg, A1C went down to 6.2 and since then I was swinging between 6.2 and 7.2. I eat lots of carbs and my physical activity is a one-hour walk three times a week. I feel hungry most of the day. My endocrinologist recommended Rybelsus, the family doctor said I shouldn't do it. I decided to go and see what happens. First month: 3mg plus Metformin 2000mg. No change in diet and exercise, lots of carbs. Minor nausea, A1C went down from 6.8 to 5.7, lost 10 lbs., morning sugar down from 135 mg/dl to 105, 2-hour sugar after meals down from 250 to 140. Second month: 7mg pills split in half. Terrible constipation for the first week. Stopped taking pills for 3 days, constipation persists with a lesser extent. Switched back to 3mg. Minor nausea, after a week, constipation almost gone. Weight no longer goes down. A1C went up to 5.9. To be continued..."

8 / 10
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  • Fan...
  • Taken for 1 to 6 months
  • October 5, 2020

For Type 2 Diabetes "I have been on Rybelsus for 1.5 months. Can’t eat, and what I do eat makes me so nauseous that it all comes back up. I have lost 10 lbs, which is great, but if this upset stomach and throwing up do not go away, then it is not worth it. I’ll give it another week, but I think I will tell the doctor I am done. My sugar levels were high, and that is why he prescribed it to take along with Synjardy. Feeling sick all the time is not worth it."

6 / 10
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35 Report
  • Anonymous
  • Taken for less than 1 month
  • April 6, 2020

For Type 2 Diabetes "I've noticed a significant change in my blood sugar levels, so I am very glad that I can control my diabetes a little more easily without having to make any major lifestyle changes. My appetite has definitely dropped, which I wouldn't expect to be possible, but I'm positive this will help me on my weight loss journey as I'm only eating 2 snacks a day. (Yes, snacks, not full meals) and have a lower carb and calorie intake. However, the nausea is unreal. I'm assuming I'll eventually get used to it and I won't be bothered, but for now, it's been somewhat uncomfortable. As far as weight loss, so far, after 3 weeks, I have lost about 2-5 pounds. My scale also sucks, so that's likely inaccurate, but I'm trusting that I'm steadily losing weight. Just got another 65 pounds to go!"

9 / 10
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35 Report
  • Sar...
  • Taken for less than 1 month
  • October 17, 2021

For Type 2 Diabetes "My A1C was slowly creeping up, and at 6.9, the Dr. wanted to start Rybelsus (3 mg). I took it exactly as directed. The side effects were immediate: constipation followed by diarrhea and extreme nausea. As I continued on the medication, nausea was constant and actually turned into stomach pain. If I ate anything, my stomach hurt worse, and I started to have an aversion to food. Any activity or exercise that involved using my core muscles was very painful. Still, I persevered knowing that it can take a few weeks to adjust to a medication. But in week 3, after side effects continued to worsen and I vomited for several days in a row, I stopped the medication. I have been off for 3 weeks now, and my stomach has not returned to normal as I have constant discomfort and it hurts after eating. I lost 10 lbs in 3 weeks, but it came at a high cost. The physical side effects were extreme, and I hope I have not permanently harmed my body. I can still only eat a few bites at any one time. Beware!"

2 / 10
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26 Report
  • Anonymous
  • Taken for 6 months to 1 year
  • November 21, 2023

For Type 2 Diabetes "I have been on this medication and don't really like how it upsets my digestion cycle. It definitely keeps you full all the time. At the same time, this is very uncomfortable. It is not a good full feeling. You are nauseous all the time. The food doesn't digest easily. It does the job as they say, but basically your food doesn't move through the pipes. You are constipated all the time because all your intestines are on slow mode. It makes you feel unhappy about the bowel movement. I am a 42-year-old with type 2 diabetes for the past 7 years. I weigh 190 lbs and trying to lose 15 lbs. Haven't lost too much weight but feeling miserable with Rybelsus 7mg."

5 / 10
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12 Report
  • CMa...
  • Taken for 1 to 6 months
  • January 11, 2021

For Type 2 Diabetes "I began taking this drug in late August 2020. It was prescribed to me by an endocrinologist to address significant weight gain over the prior two years (partially thanks to anxiety medication). The weight gain had pushed me into prediabetes, which was scary. After four and a half months, I've lost 20 lbs through reduced appetite (no real exercise). I have also seen my blood sugar levels drop. There have been occasional side effects: constipation, stomach pain, nausea. However, I have consulted my doctor, and her suggestions to manage these issues have generally helped."

9 / 10
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29 Report
  • 47...
  • Taken for less than 1 month
  • January 8, 2021

For Type 2 Diabetes "On this medication, Rybelsus, only one day. I took the 3 mg at 7 a.m., and all started out good. It controlled my appetite, and I felt fine. Then, around 3 p.m., I started feeling chest pains, not severe, just steady pinches for about 12 hours until 3 a.m. I got extreme anxiety (which I never get) and was unable to sleep until around 8 a.m. the next day. Still, I did not feel hungry the whole next day, and then the diarrhea came and lasted around 6 hours. The only meds I take regularly are heartburn and a low-dose blood pressure med. I was absolutely miserable on this medication, and I seriously considered checking into the hospital."

1 / 10
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31 Report
  • Joe...
  • Taken for less than 1 month
  • June 3, 2020

For Type 2 Diabetes "1st, I did not take Rybelsus to lose weight, only trying to get A1C down. For 10 days on this, I did not vomit, but the feeling is there, sometimes I have to gag myself to get that feeling to go away. Felt tired all the time, trouble sleeping, and my stomach always feels full. I don't have much of an appetite either, and oh boy, diarrhea the first 3 days almost seems like you can't leave the house and almost like uncontrollable, need to stay near the throne. 4-5 days later, the diarrhea seems to be better, but the nausea and vomiting feelings keep me away from this med. Also, if anyone likes to try this med, I suggest getting some ginger chew candy, it does help the nausea feelings. One more thing: if you are a guy, beware of this, your libido will go down :-("

2 / 10
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34 Report
  • Luc...
  • Taken for 1 to 2 years
  • January 6, 2021

For Type 2 Diabetes "Been on this medication for over a year. Have had several painful UTIs, nausea, bloating, low libido, sometimes increase in readings - it is not worth it. I’ve given it over a year — I’m getting off of this medication. Also, thyroid cancer possibility is a major concern."

1 / 10
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31 Report
  • Lyn...
  • Taken for less than 1 month
  • July 21, 2021

For Type 2 Diabetes "My A1C inched up to 6.1 from 5.9. I've been on 2,000 mg metformin/day. Started on Rybelsus 3 mg. Days 1-4 were OK. Day 5 I started vomiting profusely and could not hold down any food or liquid. Did not take another one. Today is day 4 that I'm off the pills, and I still vomited this morning. And this set my diarrhea issues with metformin backward. Very upset as I don't think I needed this. I've never had these types of issues, terrible."

2 / 10
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27 Report
  • Mik...
  • Taken for 1 to 6 months
  • June 9, 2024

For Type 2 Diabetes "Short story is this drug worked for me! 242 lbs Started 7.4 A1C. 3mg Rybelsus. I was really trying hard. Fast food I cut and was exercising 3 days a week. I have a sweet tooth and my wife is a great baker. She had something ready for me all the time. Sunday doughnut trips. Dairy Queen etc. Cut but not cut all out. 30 days later I did lose some weight. A1C 7.0. The Doc told me the prescribing was 3mg for 30 days then 7mg. I did exercise 4 days a week and cut the sweets some more (that was hard lol). Then the magic happened. In 150 days from start 3mg to 7mg, my A1C 5.1, 195 pounds. 5 more to go. I'm 6 ft tall. I was a fat boy at 242. Now all my old clothes fit with a belt. I know this drug won't work for everyone. However, it worked for me. It will work for you if you try hard. Don't just take the drug. I do get an upset stomach from time to time but worth it!"

10 / 10
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8 Report
  • don...
  • Taken for less than 1 month
  • January 15, 2021

For Type 2 Diabetes "I started this drug 2 weeks ago. First week okay, then the trouble began! Horrible abdominal pains, diarrhea, chills, hands became very cold, felt like I had a fever, nausea, just felt horrible. In my case, the cure was worse than the disease! Called my doctor, quite obviously, I am off this medication. May you have better luck than me!"

2 / 10
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28 Report
  • Dud...
  • Taken for 1 to 2 years
  • November 8, 2024

For Type 2 Diabetes "Lost too much weight, lost my appetite for food and life, until my diabetic nurse told me to stop the tablet at once. I had to go to A&E with a UTI, but while there they told me to see my GP and get a two-week referral. I looked so ill they thought it was cancer. Thankfully, it was not cancer. I’ve been off Rybelsus for three weeks and I am eating normally and feel much better. I believe in all honesty it would have been a close thing between me and death."

10 / 10
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5 Report
  • KCa...
  • Taken for 1 to 6 months
  • February 4, 2021

For Type 2 Diabetes "I have been on Rybelsus for 4 months, all on the 3 mg level. It's helped my blood sugar levels (8 to a 6.8), but it has caused nausea and other GI issues. My doctor kept me on the initial dosage for several extra months due to the side effects and the fact that I was achieving results with the 3. Over time, the side effects tapered, and we are now trying the 7 mg. I am hoping I won't go through the same nausea issue I went through when I first started the 3 mg. I was told that the 3 mg is not available for prescription, so it's either go up to the 7 mg or try something else."

8 / 10
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  • Tim...
  • Taken for 1 to 6 months
  • September 28, 2021

For Type 2 Diabetes "I am on my second month on Rybelsus. My A1C was 11.1 when I went to the doctor 3 months ago, and I weighed 201 at 5’4. I felt like I was going to have a stroke, in spite of being on metformin. The doctor put me on Glimepiride to quickly lower my sugar. That helped me to manage cravings, feel better, eat better, and start walking. My blood sugar would drop too low, though, and I would have to eat to bring it up. The doctor took me off that and put me on Rybelsus in addition to Metformin. I have not had any side effects other than decreased appetite, especially now that I’m on 7 mg. It's been almost 2 months on Rybelsus, and I now weigh 189 lb. I also got a Libre Freestyle 2 so I can check my sugar as much as I want with my phone and see how my body reacts to various foods. Combined together, total game changer! Highly recommend! It tells me my blood sugar average is now 118, and it keeps trending down. I am hopeful for the first time in a long time."

10 / 10
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22 Report
  • AJa...
  • July 4, 2021

For Type 2 Diabetes "I have been taking 3 mg Rybelsus since June 4th. I am not experiencing nausea nor diarrhea, however, I am experiencing constipation and loss of appetite. Since I have been taking this medication, I notice I get tired very quickly. Overall, I notice that it has helped my diabetes tremendously, and I have lost 8 lbs with very little exercise. I also take metformin 750 ER. Before starting Rybelsus, my A1C was 8.1, I do expect it to be much lower on my next visit in September."

10 / 10
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23 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.