Rybelsus and Weight Loss: What Users Say

• Koo...
• May 1, 2021

For Type 2 Diabetes "I have been taking Rybelsus for 6 months. At first, I was nauseous and had bad sulfur burps, but it went away. My A1C is the best it's been in 9 years. I have had a hard time treating my diabetes, as most other oral medications and daily injections just made life harder. Now, my numbers are 6.7, and I have lost a significant amount of weight, 335 lb to 285 lb, with minimal effort. It definitely suppresses my appetite. I've read you can only lose a few pounds, but I feel like a lucky one."

• Can...
• Taken for 1 to 6 months
• November 29, 2020

For Type 2 Diabetes "When I first started the 3mg of Rybelsus, the nausea for the first 3 weeks was nearly unbearable. However, like magic, around day 21, it stopped. I don’t feel as full as I did at the beginning now that I’m starting my second month of 7mg. However, I continue to lose weight with diet and exercise. If you’re struggling at the beginning - hold on for 30 days - it might pass like it did for me!"

• Dor...
• Taken for 1 to 6 months
• December 21, 2020

For Type 2 Diabetes "I started taking Rybelsus 3mg. I was nauseous at first and constipated. I was also belching a lot. After 2 weeks, that seemed to stop. I've been on the 7mg for 17 days and the nausea, indigestion, stomach pain, and now diarrhea have been almost unbearable and are getting worse. I've also started feeling panicky and anxious in the middle of the night with rapid heartbeat. I'm stopping the 7mg tomorrow and calling my doctor. I can't feel like this at Christmas. Going to see if she will put me back on 3mg. My A1C was 9.0. I have no idea what it is now. I've also lost 18 lbs because I can barely eat anything. This isn't worth it."

• Mis...
• Taken for 6 months to 1 year
• August 14, 2020

For Type 2 Diabetes "Started Rybelsus when it first came out in October 2019. Took 3 mg at first and my glucose levels started to rise. Changed to 14 mg and was on that for 6 months. Glucose went very low - I was tired and weak. A1C went from 10.1 to 5.2. Changed to 7 mg and feel so much better, glucose levels are still within normal limits. I've had no side effects and great results. I do take this with 5 mg of Glipizide - once a day. Have tried many diabetic drugs and Rybelsus has worked the best. I've had a slight weight loss... under 10 lbs. So glad I tried this drug. It's a winner in my book."

• Jer...
• Taken for 1 to 6 months
• June 20, 2023

For Type 2 Diabetes "It was a disaster for me. My A1C used to stay between 7.5 and 8.5, and morning fasting readings were high, like 130 to 160. Increasing Glimepiride from 4 mg up to 8 mg didn't work. My doctor started me on 3 mg/day of Rybelsus. It caused constipation, upset stomach, and a lot of burping. But morning fasting readings came down to around 100, so I was tempted to try it out. After finishing the 3 mg dose for 30 days, I started taking 7 mg/day. My symptoms worsened: constipation, loss of appetite, noisy stomach, lots of burping, GERD, and weight loss from 152 lbs to 139 lbs in just about a couple of months. I could not afford to lose any more weight. I also saw some foamy urine indicating it was affecting my kidney function too. I stopped taking Rybelsus under my doctor's advice, and since then, the constipation is gone, the burping is gone, the appetite is good, and life seems back to normal. I still need to check on my kidneys for any issues since foamy urine is still there. The last A1C was 7.9."

• Dud...
• Taken for 1 to 2 years
• November 8, 2024

For Type 2 Diabetes "Lost too much weight, lost my appetite for food and life, until my diabetic nurse told me to stop the tablet at once. I had to go to A&E with a UTI, but while there they told me to see my GP and get a two-week referral. I looked so ill they thought it was cancer. Thankfully, it was not cancer. I’ve been off Rybelsus for three weeks and I am eating normally and feel much better. I believe in all honesty it would have been a close thing between me and death."

• Anonymous
• March 26, 2022

For Type 2 Diabetes "Beware. My doctor had me transition to 7 mg after only being on the 3 mg for two weeks. I could not stop vomiting after taking the pills for 5 days. I lost a ton of weight but ended up in the hospital getting my gallbladder removed and not eating for two weeks."

• cat...
• Taken for 1 to 6 months
• June 23, 2023

For Type 2 Diabetes "I have been taking Rybelsus for about 3 months. I have had nausea and weight loss. My blood glucose level is much better. It's even sometimes low. I now wear a continuous glucose monitor. I have random nausea after taking the medication in the mornings and can experience nausea during the day if I eat too much or greasy food. I think this is what causes some of the weight loss. You just don't want to eat if you have nausea. I do occasionally get a headache and constipation if I don't drink lots of water. The drug makes me not want to eat, but it also makes me not want to drink, so I have to force myself to drink water, or I get dehydrated and constipated. This drug makes me forget to eat or drink. It's strange. The good side effect is weight loss. Bad is nausea. My insurance does cover it."

• GEL...
• Taken for 1 to 6 months
• July 15, 2024

For Type 2 Diabetes "Find it difficult to take as it makes me quite nauseous. I have been taking it at 12 noon one hour before my lunch. I started off taking it at 3 a.m. when I usually awaken for a visit to the loo, and this lowered my blood glucose very well in the early morning, but then I was not getting enough sleep. However, I could not cope with the side effects and stopped taking it. Since reintroducing it, my morning glucose readings have been in the region of 12-15 mmol/l, which is not great. However, I am on 7mg of Rybelsus. I cannot drink more than 2 glasses of wine, which is good. Also, it has reduced my appetite substantially, which is also good, and I lost 3 kg in weight when I started taking it."

• Jay...
• Taken for 1 to 6 months
• June 22, 2024

For Type 2 Diabetes "I've been on Rybelsus now for 4 months. I started on 3mg then upped to 7mg after a month. My blood sugar levels are just starting to come under control from highs of 12 down to around 6.5 - 7.5. I've started noticing some weight loss as my clothes are feeling looser. I know this drug is expensive, but I'm in the UK and don't have to worry about costs as our NHS provides us with all medications for free."

• Sti...
• Taken for 1 to 2 years
• August 16, 2024

For Type 2 Diabetes "I started on Rybelsus 3 mg, after a month, my doctor increased it to 7 mg. Like most people, I had to plan my morning so I had time to take it well before breakfast to lessen the sickness. I had serious nausea, sickness, and weight loss (28 lb), my glucose, kidney function, and cholesterol all improved, and I was very pleased. Two years in, and I had to stop taking it. I had developed piles the size of golf balls (never had those before), my anus and perineum constantly itched, as well as under my breasts and armpits. It was so uncomfortable, driving me mad, so I reduced it back down to 3 mg to see if it eased the symptoms, and it did. I stopped it completely in January, and it has taken until now (August) for the piles and itching to completely go. I have put some of the weight back on, and my glucose levels are up again. There are other medications, but they too have some horrible side effects, just be careful what you start. I am waiting to see what else my doctor can offer with fewer side effects."

• Ryn...
• Taken for 1 to 6 months
• February 9, 2022

For Type 2 Diabetes "I started on this medication in December. It immediately lowered my blood sugar, however, it made me very nauseous and have a loss of appetite. It is now February, and I have lost 15 lbs. I still don’t have much of an appetite these days. I find eating very light meals 2x a day helps a lot. Trying to stick with it."

• udg...
• Taken for 1 to 6 months
• February 14, 2025

For Type 2 Diabetes "Terrible nausea and violent diarrhea. Fatigue. Minor weight loss. Blood sugars stabilized."