Prucalopride and Bloating: What Users Say

• fes...
• Taken for 1 to 6 months
• November 30, 2019

For Chronic Idiopathic Constipation "I tried this daily for 7 weeks-almost at the end of the 2nd refill. It worked a little for the first 10 days or so, but there were no results at all since, and unfortunately, there were very unpleasant side effects of severe gas, severe bloating, and abdominal pains. It was very expensive too. I'm not going to refill. No results and bad side effects."

• Ksa...
• July 4, 2021

For Chronic Idiopathic Constipation "I can't poop. Laxatives, stool softeners, Amitiza, Linzess, every other drug you can think of either worked a few times and just stopped. I had high hopes for Motegrity. I took Motegrity three times, just to be sure my symptoms were actually caused by the drug. Motegrity produced a bowel movement for me within a day of taking the drug, each time. My third bowel movement on Motegrity was a bloodbath. Anyway, within 15 minutes of taking the drug, each time, my stomach severely bloated. As time passed, my abdomen would hurt even more and horribly burn-if anyone has ever had bowel obstructions or intussusceptions, the pain and burning felt like this. Then began the migraine, nausea, and vomiting/dry heaving. My abdomen felt as if I was getting lit on fire and ripped to shreds; screaming pain. Of course, I felt the need to take this godforsaken drug two more times, you know, just to be sure-as if the first round of torture wasn't enough. Now I have bloody stools."

• Deb...
• September 7, 2020

For Chronic Idiopathic Constipation "One Motegrity pill, and had side effect of a horrible headache, and it made my stomach so upset, and one day out still feeling like I'm going to throw up and bloating. Never again. I will no longer be ever taking this pill. I'm so sick from just this one pill."

• Kal...
• Taken for less than 1 month
• October 8, 2024

For Chronic Idiopathic Constipation "It works!!! First day I took it, I did have a migraine. Following days I got lucky and no migraine. I actually have solid bowel movements and go 2-3x a day. I take it early in the morning. I tried Linzess and Trulance, which caused bloating and watery diarrhea, and I couldn’t leave my house for 4-6 hours. Some days it wouldn’t work and caused more bloating. I highly suggest giving Motegrity a try. It saved me."

• Kay...
• January 6, 2021

For Chronic Idiopathic Constipation "I took Motegrity one day, and I barely made it through the day. Started with diarrhea and extreme bloating and stomach pains. Then started getting dizzy and head hurting. By that night, I had a pounding headache, could barely stand, running to the bathroom-dizziness-it was awful. I felt so sick I almost went to the ER. Day two, and I still have a lingering headache and diarrhea, stomach pains, and extreme bloating. Never taking this pill again. I must mention I have also tried Linzess and also experienced extreme bloating and diarrhea, but none of these other symptoms."

• Ann...
• Taken for less than 1 month
• May 16, 2023

For Chronic Idiopathic Constipation "I wanted to share my story as I just took my first dose of this medication tonight. I'm crossing my fingers because nothing else has been effective, and I am currently down to 107 pounds at a height of 5'5". During the lockdown, I was exposed to toxins in a home I had recently moved into. After four months of being there, I experienced a wide range of symptoms, including severe gastric emptying delay and dysfunction in my colon. Whenever I eat, I suffer from severe consequences. At the moment, I'm on my third round of Xifaxan, which costs $2500 for each two-week treatment, and my gastroenterologist suspects it might be small intestinal bacterial overgrowth (SIBO) as well. Xifaxan helps with reducing inflammation and bloating, but unfortunately, my colon isn't improving. Currently, the only thing I am able to eat without major issues is eggs, and even then, I have to use a daily enema. I also have eosinophilic esophagitis (EOE) and have undergone several surgeries involving scopes, biopsies of the esophageal area, and laparoscopic exploratory surgery. As I enter my third year with these conditions, they are getting worse."

• Anonymous
• Taken for less than 1 month
• February 26, 2022

For Chronic Idiopathic Constipation "I have taken it 3 times, and each time the same side effects, all within 15 minutes of taking the medication. Bloating was the worst, along with stomach ache, nausea, and severe headache!! No thanks."