Prucalopride and Anxiety: What Users Say

• Roz...
• Taken for 1 to 6 months
• November 11, 2020

Prucalopride for Chronic Idiopathic Constipation "I took this med for about 2 weeks for gastroparesis, then started to have psyche side effects. I stopped the drug for a few days, then started up again as it worked so well. Lo and behold, the same thing happened. A few more tries, and this time the side effects outweighed the good. It took me a week to feel better mentally, but I am still very anxious. Works well, but not worth the cons."

• Ser...
• Taken for less than 1 month
• October 13, 2021

Prucalopride for Chronic Idiopathic Constipation "Motegrity does work, but the effect on me is harsh, and I have many side effects. I took 2 mg about six hours ago. It hit within 15 minutes. Since then, I have gone to the bathroom about 15 times. I didn't make it to the toilet a few times. I'm experiencing a racing heart, pounding headache, a jittery/shaky feeling, and intense nausea. I'm dizzy, weak, and achy. I take many other meds for other conditions, and for all I know, they've left my body. There's no way I could deal with this every day. Not sure if I'll try it again, definitely not anytime soon."

• Poo...
• Taken for less than 1 month
• December 24, 2021

Prucalopride for Chronic Idiopathic Constipation "My daughter has autism and has had constipation all her life. She has always been on medication for her autism. Motegrity has her making complete bowel movements, but her behavior has become erratic. She is anxious and is having compulsive behaviors. I'm going to stop Motegrity for a few days and see how she acts. If her behavior improves, I know it's the Motegrity. A shame because it is helping her. I'm only giving her 1 mg."

• Dot...
• February 5, 2021

Prucalopride for Chronic Idiopathic Constipation "I have been on Motegrity for over a year, and it worked great for a while, lately, I have had problems with feeling jittery, anxious, and depressed. Feeling jittery and anxious is the worst. I have gastroparesis and am also on Famotidine, Promethazine, Lansoprazole, and Motilium, so it may be a combination or the Motegrity."

• Dot...
• February 5, 2021

Prucalopride for Chronic Idiopathic Constipation "I have been on Motegrity for over a year, and it worked great for a while, lately, I have had problems with feeling jittery, anxious, and depressed. Feeling jittery and anxious is the worst. I have gastroparesis and am also on Famotidine, Promethazine, Lansoprazole, and Motilium, so it may be a combination or the Motegrity."

• Nut...
• Taken for 1 to 6 months
• August 11, 2022

For Chronic Idiopathic Constipation "I have tried a variety of medications. Lubiprostone (Amitiza) works the best, but it still wasn't enough. I also still use Miralax almost daily and a stool softener once or twice a week. Adding prucalopride to these has helped to give me regular, predictable bowel movements. I take 1/2 pill (1 mg) once a day or every other day. So I'm pleased with how it helps with constipation. But I am minimizing the dose because it affects me like an SSRI antidepressant, which I've been on before and really dislike. Like SSRIs, prucalopride increases serotonin, which is helpful in stimulating bowel contractions, but unfortunately also affects the brain. I feel spacey, emotionally vulnerable, anxious, and sometimes depressed. Prucalopride is not covered by my insurance, but I was able to obtain it affordably through an overseas pharmacy."

• Dow...
• Taken for less than 1 month
• July 4, 2021

For Chronic Idiopathic Constipation "I was given samples of Motegrity because I have pelvic floor dysfunction, IBS-C, gastritis, and a bit of gastric emptying delay. I wanted this to work so badly! The first day produced a perfect BM, but I have migraines and thought one was coming on all day. The next day, BM again, but I started having anxiety over dying! What? Depression hit the third day. I’m done! Going to just take senna. Nothing else works."