Methylnaltrexone and Diarrhea: What Users Say

• Nie...
• March 8, 2016

For Constipation, Drug Induced "I have been on opioids for 29 years now. About 10 years ago, my doses were so high and the constant pushing because of fecal impaction unless I was taking 10 laxatives at night to wake up with unbearable cramps to have diarrhea, then taking more laxatives throughout the day cured the fecal impaction. But I ended up with an external prolapsed bowel that would come out even going to the bathroom. The doctors had never seen one completely outside, which I would have to manually push back in every time. Surgery was 10 nights in the hospital on one of those automatic beds that move position so you don't get bedsores. 1000+ stitches and staples and now Relistor doesn't always work, but when it does, OMG! It feels like heaven. Yeah!!!!"

• pop...
• Taken for 2 to 5 years
• October 4, 2018

For Opioid-Induced Constipation "I have been on sustained release morphine for several years for chronic pain from MS and fibromyalgia. I also have a neurogenic bowel and bladder from MS. I have to do a lot to make sure my bowels stay regular. Relistor definitely makes things easier. I can usually have a bowel movement with 1 shot, although not always. The downside is sometimes it works too well and I have diarrhea for a few hours. The injections themselves are easy and relatively painless."

• Puc...
• February 21, 2013

For Constipation, Drug Induced "I started the Relistor injections about 3 weeks ago. I was to inject 8 mg but was given the 12 mg syringe on the doctor's order. Very difficult to discard the extra mg because the syringe is not clearly marked. I now have the 8 mg syringes, which I should have gotten to start with. I take the Relistor every other day, and it works in 5 minutes. I set aside 2 hours to deal with the results. 5 to 6 bowel movements, including some diarrhea. I go from bed to bathroom and back again until done. My main problem is the nausea that accompanies the process. I did experience vomiting after the first injection, but now it is only nausea. I take Zofran a half-hour before the injection for nausea, and it helps but doesn't completely take care of it. Even with the unpleasant side effects, I am glad to have this medicine to treat the slow GI movement I have due to scleroderma, diabetes, and the opiates I take for chronic back pain."