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Synvisc-One User Reviews & Ratings (Page 5)

Synvisc-One has an average rating of 5.8 out of 10 from a total of 174 reviews on Drugs.com. 49% of reviewers reported a positive experience, while 40% reported a negative experience.

Reviews for Synvisc-One

Commonly mentioned side effects
  • Jon...
  • Taken for less than 1 month
  • April 29, 2017

For Osteoarthritis "The first two nights, I could sleep on my side without pain, but the third night I could not, and the third and fourth mornings I woke up with sharp pain in both knees, making it difficult to walk. This is actually worse than before I had the injections. Am I expecting too much? When can I expect the pain to go away or at least not be present with every step I take?"

1 / 10
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17 Report
  • Mrs...
  • Taken for 1 to 6 months
  • October 31, 2016

"I had 4 rounds of Synvisc-One injections and took the last one on May 31, 2016. It's been 5 months, and I can barely walk. I cannot straighten my leg and walk with a limp. These injections are not good. Wish I read reviews first. I do not recommend these injections at all. Wish I had just had the surgery."

1 / 10
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19 Report
  • Bea...
  • Taken for less than 1 month
  • October 6, 2019

For Osteoarthritis "I had a Synvisc-One injection in each knee. My right knee had no problems. My left knee filled with fluid after 24 hours. I had nausea, chills, pain, and a grapefruit-sized knee. I had it drained, and it instantly felt better. I was able to walk again. It has filled up again, not as painful, but still can't sleep due to pain. Waiting for lab results on the fluid."

6 / 10
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12 Report
  • She...
  • Taken for less than 1 month
  • December 11, 2021

For Osteoarthritis "Most of the reviews I saw were for older people, and I figured I would leave a review for someone who is in their mid 30s. I had a bad motorcycle accident 4.5 years ago, where I broke my femur right at the knee. I have severe OA. My doctor kept recommending Synvisc-One for years, but I kept putting it off. My knee got so bad I was wearing a knee brace to reduce pain. I got my first gel injection 2 days ago. The shot itself was completely painless. They just used a skin-numbing spray, and I felt nothing, it was over before I realized what was going on. My knee felt like it was floating for the first day. Since the gel injection, I have not had to wear the knee brace. I am on day 2, and it still hurts a little, but nowhere near where it was. I know it can take 2 days to a month to work, so I am hopeful. I really haven’t had any side effects, which is awesome. Overall, I think I will get it again in 6 months to a year."

10 / 10
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7 Report
  • Ted...
  • November 10, 2019

For Osteoarthritis "I have my Synvisc-One injection in Aug 2018, and in Oct 2019 I got another injection, not by the same doctor. For me, this was a big mistake. My 1st injection in 2018 was perfect, no problems, and lasted over a year. For some reason, I changed doctors. It was the most painful shot I have ever had. When I returned to his office, he then discussed that over time and injections it can be more symptomatic. I should have been told that BEFORE the second injection. The doctor told me to check the medical literature. I did and can't find it. The second injection caused pain to radiate from my knee down my leg and from my knee to my hip, it's been three weeks. I'm going back to my old doctor to see if he can fix it. There are other injections (Monovisc) like Synvisc-One, and rotation between these injections may be an idea for anyone using Synvisc-One."

6 / 10
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11 Report

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  • big...
  • August 25, 2016

For Osteoarthritis "After having a few cortisone shots and not much luck or longevity with them, my Dr. asked me to try the Synvisc-One, and I was reluctant at first, but when you have 100% bone on bone in one knee and 75% bone on bone in the other, I was willing to try anything. I had to wait also to be approved by Wellness Blue Cross Blue Shield. It was finally approved, and I had the shots in late July. I'm 49 years old and a bigger, heavier man, and I made my 15-year-old son come in to watch. It hurt like heck. My son was shocked to see me wincing in pain the entire time. It takes a little while to get it all in your knee as well. Then to my other knee, I gripped the table and said my god, nobody said they were this painful. Swelled up so bad for a week. Never helped me."

1 / 10
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20 Report
  • San...
  • Taken for less than 1 month
  • November 11, 2019

For Osteoarthritis "Had one Synvisc-One injection a week ago in a knee that before the injection only hurt when walking up or down stairs. Immediately, I had a stuffed nose, swollen tongue, never had headaches, but now nausea and headaches. Worst of all, my leg and veins hurt so badly all the time that I haven't had a quality day for a week and haven't slept because of the pain because nothing helps. Tried pain rubs, creams, natural pain meds, and no relief. I avoided stairs for five years and will gladly do it again if I can get this terrible experience out of my body. I give this a one, and from the comments given, I should have never taken this in the first place. Dishonest doctor!!!"

1 / 10
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  • Mac...
  • May 28, 2019

For Osteoarthritis "Wife, 74, has bilateral primary osteoarthritis of knees. She has been on Euflexxa, three shots over three weeks, every six months, for the past few years with excellent results. We switched insurance, and the new insurance insisted on Synvisc or Synvisc One. She went into the clinic this morning to get her Synvisc One injection. The physician's assistant (PA) had a trainee with her and explained that you have to feel for the soft spot adjacent to the kneecap to determine where to inject. My wife felt more pressure than she had experienced with the Euflexxa, and a little soreness, but almost no pain. She felt better after the injection and was able to walk out of the hospital and return home, no more than the normal discomfort. She is currently icing her knees and, so far, is very pleased! I know it is early, but it went really well and gives us hope that the osteoarthritis in her knees won't get progressively worse."

10 / 10
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11 Report
  • Tho...
  • Taken for less than 1 month
  • September 27, 2016

For Osteoarthritis "Finally had my second injection of 2016 Synvisc, why did I wait for so long? Surgeon treated my right knee with Synvisc over 5 years ago during surgery, however, unsuccessfully rebuilt my right knee. Was unaware of the relief that the Synvisc drug possesses. I was in constant pain with both of my knees, right being the worst, sometimes a 10. Don't get me wrong, Synvisc did not cure the pain, it still happens from time to time, but no spikes and so far no 10's! I had double meniscus tears, ACL tear, and osteoarthritis in my right knee. Left is not too much better, but ACL intact, sometimes a 6 but not 10 like the right was. Only pain was a normal blood draw, my doctor froze the area. I sat up to watch the injection. Immediate relief, stayed off the knee as requested."

10 / 10
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14 Report
  • Cle...
  • November 10, 2019

For Osteoarthritis "I'm scared now after reading all these comments. I'm actually glad that most of them are positive, but I am barely 27 y/o and I had already 2 surgeries in my knees due to meniscus issues, and now I'm having loss of cartilage and need to get these shots for my knees. I have always been sick with other stuff, but it scares me that it might not work on me since I am already limited to doing some physical activities. I hope this actually works for me. Thanks for sharing your experiences, and I hope all of you are doing better. God bless."

6 / 10
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11 Report
  • Ros...
  • Taken for less than 1 month
  • February 22, 2019

For Osteoarthritis "I had my first injection two weeks ago into my left knee. I started suffering pain immediately after the numbing used during the injection had worn off. The pain I am experiencing is much worse than what I had prior to the treatment. I am having to take anti-inflammatory painkillers just to be able to walk, whereas prior to the treatment I only used them when my knee was sore after being on my feet for a while. I have had ACL reconstructive surgery, and my knee has deteriorated over time, and this was done in an effort to delay knee replacement surgery. I will not be getting any more injections."

1 / 10
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10 Report
  • Wes...
  • Taken for 6 months to 1 year
  • September 20, 2018

For Osteoarthritis "I had Synvisc put into both knees at the same time as I had arthroscopy on the left knee. Both knees felt like they had lumps of concrete in them for 6 months. They were heavy, and my movement was restricted and painful. Never, ever, ever again!!"

1 / 10
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  • Veh...
  • August 22, 2017

For Osteoarthritis "I just got the injection at 4:30. It is now 6 PM, and I cannot walk on my leg. The side of my thigh hurts. The nurse took me to my car in a wheelchair because I could not walk. She said she has never seen anyone react that way. People get the injection and walk out. Not me. I will never get that injection again. The pain afterward was horrible."

2 / 10
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15 Report
  • Did...
  • September 27, 2017

For Osteoarthritis "Following on from my previous comments, it has been three weeks since I had the injections and the right knee drained (twice). After resting and icing for two weeks, I am now back to normal. No more popping/clicking. Started walking last week and slowly built up the distance. Walked 8 km this morning and had no problems. Just needed to stretch before and after, which I should be doing anyway. Hope to get another 9 months out of it. Am willing to put up with 2-3 weeks of pain to get 9 months of relief (and a life)."

7 / 10
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13 Report
  • Gin...
  • Taken for 1 to 6 months
  • March 23, 2019

For Osteoarthritis "Chondromalacia in both knees with meniscal tears and loss of cartilage. First two weeks post-injection, my knees felt great. Third week, my knees began to hurt again with sharper pain than before. I am currently in the ER because my left leg is so stiff and painful I can't bend or straighten my left leg. Only came to the ER because the right is starting to stiffen up."

1 / 10
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10 Report
  • LDu...
  • April 27, 2017

For Osteoarthritis "I need bilateral knee replacement, but due to being only 50, we are trying to put it off if we can. Had both knees injected April 24, 2017. No numbing used, and the injections were quite unpleasant. I'm on day 4 and feel minimal difference in the right knee and still have dreadful pain in the left. Unless something changes in the next couple of days, I most likely will not do this again. Have opted to get the surgery."

2 / 10
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12 Report
  • Lua...
  • Taken for 2 to 5 years
  • October 14, 2019

For Osteoarthritis "Bilateral knee 'osteoarthritis.' Injection every 6 months administered with lidocaine, using ultrasound guidance. Works great, as long as administered correctly. Pain gone, flexibility somewhat restored. Rather this than knee surgery, but my knee X-rays show only mild osteo."

9 / 10
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8 Report
  • Bob...
  • Taken for 1 to 6 months
  • May 24, 2018

For Osteoarthritis "Had the 3 shots all together, shot worked very well, forgot I had the problem, that’s how effective. However, it’s 7 months now, and I’m feeling that knife turning again in my knee, so going to do it again. I just wish it stayed longer, but it’s well worth the shot. No serious side effects. This shot is a blessing."

10 / 10
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9 Report
  • Sno...
  • August 2, 2017

For Osteoarthritis "After suffering acute hip pain, femoral edema, shock wave therapy, MRI scans revealed loss of cartilage and some arthritis. I had a cortisone injection which worked for 2 weeks and back to 10/10 pain. I had the Synvisc-One injection which was very painful and had no effect for 4 weeks, after which every day mobility improved and pain-free movement. With regular physiotherapy, the mobility continues to improve every day after the treatment 4 months ago, and I hope the results continue. 100% recommend the product, thanks so much for my improved quality of life."

10 / 10
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  • Tra...
  • Taken for 2 to 5 years
  • August 4, 2018

For Osteoarthritis "Had first round of shots in left and right knees last year, which lasted 9 months. Due to my limited mobility and obesity, Doc recommended I do low-impact water aerobics and NO MORE pavement walking. The shots worked with 80% relief and hardly any sharp pains or clicking, only once in a while if I turned funny. The knees would 'catch,' so this med was great! Lost 38 pounds in 9 months, now walking on trails again and able to do slow flow and fundamental yoga, so have moved up from just swimming! Ready to lose the last 60 pounds! Had second shots today, and my legs felt very fatigued walking a mild 20-minute stroll tonight. I have a headache and a little nausea, but not bad. Doc's advice was to get as light and lean as possible in a healthy weight range. I look forward to it - that's my plan. Best of luck and light to us all!"

9 / 10
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9 Report
  • See...
  • Taken for 1 to 6 months
  • March 13, 2021

For Osteoarthritis "I had a Synvisc-One injection in late November due to osteoarthritis that has made my left knee very swollen at times and even caused it to lock up for weeks. The doctor that administered the injection has a very good reputation, and it was only mildly uncomfortable when he was injecting it. However, it has done absolutely nothing for my knee, and in fact, my left heel has been bothering me ever since the injection in my left knee. It burns and is painful to walk on, but I keep pushing through. While I also suffer from extremely over-pronated feet, I have never experienced pain in either of my heels. Could be a coincidence, but I am not so sure. I am happy that it does seem to work for some people, though."

1 / 10
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6 Report
  • Bab...
  • March 19, 2018

For Osteoarthritis "After reading the reviews of those who have had the Synvisc shots, I am surprised at the level of pain some are describing. My ortho doc did tell me that some people don’t react well, that their knees “blow up,” especially after the 4th or 5th time, and if that were to happen, to come right back. Maybe I am just lucky - no bad reaction, just pain free. It takes about 4 weeks for the injection to take full effect. My first shot of Synvisc One was in May 2016. It was not painful to have the shot, as my rheumatologist also used some local anesthesia with it. Within a month, I was pain free in my knee. I previously was wearing a brace on my knee. Since then, I have had the shot every 6-8 months in my left knee (from my ortho doc). I occasionally have a “little” pain if I overdo things, but it goes away once I rest for a bit. I’ve had the shot 4 times now; just a couple days ago was the last time. Only a tiny bruise at the site, and very slight swelling. That’s it. Worth it not to have pain for 6-8 months."

10 / 10
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10 Report
  • Sti...
  • August 11, 2016

For Osteoarthritis "After years of knee problems and taking cortisone, I was recommended by a knee specialist to try Synvisc-One injections. After approximately $635 and an extremely painful injection (much more painful than cortisone), I had absolutely no relief whatsoever, just a waste of time and money. Now I am back on cortisone injections until they can come up with another alternative :("

1 / 10
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15 Report
  • Did...
  • Taken for less than 1 month
  • September 10, 2017

For Osteoarthritis "I had my first shot of Synvisc in my right knee in February 2016, as it kept clicking/popping due to OA. Found the first shot to be amazing. Was walking normally the next day. Six weeks later, decided to have my left knee done. Again, amazing, I could walk without any problems. Six to seven months later, I had both knees done at the same time. Lost some weight, rode the exercise bike, and walked a lot. This time, I had nine months of relief. Went back for a third round. Had Synvisc in my right knee and another product in my left. No problems with my left knee, but my right knee swelled up and had to be drained (twice). I had obviously built up a sensitivity to it. My right knee is back to clicking/popping every couple of steps, which is really annoying."

7 / 10
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10 Report
  • Gau...
  • Taken for less than 1 month
  • September 27, 2017

For Osteoarthritis "Sept 2017 - Looks like I am not alone. It has been 20 days since the injection. I have fluid buildup and cannot bend my knee. Finding it hard to walk, as I cannot bend my knee. I wished I had read reviews before getting the injection."

2 / 10
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10 Report

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