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Hylan G-F 20 Dosage

Medically reviewed by Last updated on Sep 12, 2018.

Applies to the following strengths: 16 mg/2 mL; 48 mg/6 mL

Usual Adult Dose for Osteoarthritis

Inject 2 mL intra-articularly into the knee once a week for 3 weeks.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available


Safety and effectiveness of repeat treatment cycles have not been established.


Data not available; however, due to the high molecular weight of hylan G-F 20 it is not likely to be dialyzable.

Other Comments

Disinfectants containing quaternary ammonium salts will cause hyaluronic acid precipitation and should not be used for skin preparation.

Hylan G-F 20 should be used cautiously in patients who are allergic to avian products, feathers, and egg products.

Patients should be advised to avoid any strenuous or prolonged weight-bearing activities for 48 hours after the injection.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.