Hylan g-f 20 Side Effects
For the Consumer
Applies to hylan g-f 20: injection solution
Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur while taking hylan g-f 20:
Knee pain or swelling after injection.
Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); ankle swelling; bruising; calf cramping; fast heartbeat; fever; hemorrhoids; muscle pain; nausea; persistent pain, redness, or swelling at injection site; sweating.
For Healthcare Professionals
Applies to hylan g-f 20: intra-articular solution
A retrospective study reported pain, warmth, and swelling after 11% of injections, in some cases lasting up to 3 weeks.[Ref]
In clinical trials with 511 patients who received a total of 1771 injections, knee pain and/or swelling were reported in 7.2% patients or 2.2% of injections and were the most common adverse reactions.[Ref]
Dermatologic side effects have included individual cases of rash, itching, generalized urticaria, recurring small hives, facial flush with lip swelling, and body prickling. These symptoms did not reoccur upon rechallenge.[Ref]
Gastrointestinal side effects have included nausea and hemorrhoids.[Ref]
Musculoskeletal side effects have included calf cramps, ankle edema, muscle pain, low back sprain, and pseudosepsis.[Ref]
Pseudosepsis has been characterized as severe joint inflammation with pain and effusion occurring 24 to 72 hours after injection and it may be more likely to occur after the second or third injection or with repeated courses. Nonsteroidal anti-inflammatory drugs, intra-articular steroids, and/or arthrocentesis are often required to treat pseudosepsis.[Ref]
Cardiovascular side effects have included tachyarrhythmia and phlebitis with varicosities.[Ref]
Nervous system side effects have included anxiety and listlessness, dizziness, headache, shivering, and body pain.[Ref]
Respiratory side effects have included respiratory difficulties.[Ref]
Metabolic side effects have included one case report of pseudogout and one of acute gout in a patient with no prior episodes.[Ref]
Hypersensitivity reactions have included one reported case of a suspected allergic reaction with fever, large effusion in the knee, and synovial eosinophilia.[Ref]
Local reactions have included acute painful joint effusions after injection into the knee in 1% to 11% of patients.[Ref]
1. "Product Information. Synvisc (viscoelastic solution)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
2. Isomoto H, Saenko VA, Kanazawa Y, et al. "Enhanced Expression of Interleukin-8 and Activation of Nuclear Factor Kappa-B in Endoscopy-negative Gastroesophageal Reflux Disease." Am J Gastroenterol 99 (2004): 589-97
3. Yacyshyn EA, Matteson EL "Gout after intraarticular injection of hylan GF-20 (Synvisc) [letter]." J Rheumatol 26 (1999): 2717
4. Allen E, Krohn K "Adverse reaction to Hylan GF-20." J Rheumatol 27 (2000): 1572
5. Pullman-Mooar S, Mooar P, Sieck M, Clayburne G, Schumacher HR "Are there distinctive inflammatory flares after hylan g-f 20 intraarticular injections?" J Rheumatol 29 (2002): 2611-4
6. Puttick MP, Wade JP, Chalmers A, Connell DG, Rangno KK "Acute local reactions after intraarticular hylan for osteoarthritis of the knee [see comments." J Rheumatol 22 (1995): 1311-4
Not all side effects for hylan g-f 20 may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
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