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Synvisc-One Side Effects

Generic name: hylan g-f 20

Medically reviewed by Last updated on Mar 5, 2024.

Note: This document contains side effect information about hylan g-f 20. Some dosage forms listed on this page may not apply to the brand name Synvisc-One.

Applies to hylan g-f 20: injection injectable, injection solution. Other dosage forms:

Serious side effects of Synvisc-One

Along with its needed effects, hylan g-f 20 (the active ingredient contained in Synvisc-One) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking hylan g-f 20:


Other side effects of Synvisc-One

Some side effects of hylan g-f 20 may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common


For Healthcare Professionals

Applies to hylan g-f 20: intra-articular solution.


Frequency not reported: Rash, itching, hives, itching, face swelling, generalized urticaria[Ref]


Frequency not reported: Hemorrhoids, nausea, tonsillitis[Ref]


Frequency not reported: Low back sprain, calf cramps, muscle cramps

Postmarketing reports: Acute inflammation (e.g., joint pain, swelling, effusion, joint warmth and/or stiffness)[Ref]


Frequency not reported: Tachyarrhythmia, phlebitis with varicosities, flushing[Ref]

Nervous system

Frequency not reported: Headache, dizziness, chills, paresthesia[Ref]


Frequency not reported: Respiratory difficulty[Ref]


Frequency not reported: Synovial eosinophilia[Ref]


Postmarketing reports: Injection site pain, injection site swelling[Ref]


Rare (less than 0.1%): Thrombocytopenia[Ref]


Frequency not reported: Ankle edema, fever, peripheral edema, malaise[Ref]


1. "Product Information. Synvisc (hylan G-F 20)." Wyeth-Ayerst Laboratories

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.