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User Reviews for Diflucan

Diflucan has an average rating of 6.0 out of 10 from a total of 134 ratings on Drugs.com. 52% of those users who reviewed Diflucan reported a positive effect, while 35% reported a negative effect.

Condition Avg. Rating Reviews Compare
Vaginal Yeast Infection  
5.9
112 reviews 58 medications
Candida Urinary Tract Infection  
5.2
6 reviews 7 medications
Esophageal Candidiasis  
4.8
4 reviews 10 medications
Candidemia  
9.3
4 reviews 15 medications
Tinea Versicolor  Off-label
5.3
3 reviews 96 medications
Oral Thrush  
9.5
3 reviews 31 medications
Cryptococcal Meningitis, Immunosuppressed Host  
9.0
1 reviews 8 medications
Fungal Infection, Internal and Disseminated  
8.0
1 reviews 2 medications
Summary of Diflucan reviews 6.0 134 reviews

Reviews may be moderated or edited before publication to correct grammar and spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest in the medication will not be published. As reviews and ratings are subjective and self-reported, this information should not be used as the basis for any statistical analysis or scientific studies.

Reviews for Diflucan

RR · Taken for less than 1 month March 11, 2021

For Tinea Versicolor: “No side effects at all, male 33 with candida in groin, on my 2nd dose and I see and feel a big difference, the candida is going away I might need one more dose in case, to prevent. But no side effects on me, and I'm on Lexapro, beta blockers.”

10 / 10
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kuno78 · Taken for less than 1 month February 24, 2021

For Candida Urinary Tract Infection: “It would have been very nice to have known beforehand that Difucan contains fluoride, which messes with iodine. I have thyroid problems and bipolar, so it is been real fun puking my brains out while having a complete breakdown. This stuff also has the added plus of switching your yeast infection to a bacterial infection.”

1 / 10
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kuno78 · Taken for less than 1 month February 23, 2021

For Vaginal Yeast Infection: “Never again One day after taking difucan, I got a splitting headache, severe dizziness, and nausea with vomiting”

2 / 10
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Frequently asked questions

Anastacia · Taken for less than 1 month January 29, 2020

For Vaginal Yeast Infection: “Fluconazole: Brand name Diflucan worked like magic for me. It sounds like a yeast infection may have been the wrong diagnosis for some of you all judging from the symptoms or the yeast infection may have been more severe which may have called for a double dose on the first day vs. the one dose of 150mg. What helped me was drinking plenty of water to flush the medicine through my system, eating yogurt with probiotics, urinating as much as possible, and flushing my exterior vulva with cool water for relief to rinse the yeast from my skin. (((Do not rub or scratch your vulva because that contributes to swelling, inflammation, and irritation ))). Sit on the toilet or tub and rinse with a large cup of cool water and pat dry. I AVOIDED ALCOHOL FOR AT LEAST ONE WEEK while the antibiotic took its course. I was healed completely in less than 3-4 days.”

10 / 10
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Carol · Taken for 1 to 6 months April 7, 2020

For Vaginal Yeast Infection: “I’ve had yeast infections in the past and this medication has made it go away with no problem at all. However, I’ve been having a yeast infection for 4 months now, yes 4 WHOLE MONTHS and it doesn’t go away with taking this medication that my obgyn only seems to be prescribing me. It’s nothing else but a yeast infection and Diflucan doesn’t work for me anymore. I’m going to have to try boric acid suppositories...”

2 / 10
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Alynn December 19, 2019

For Vaginal Yeast Infection: “I took a course of antibiotics for BV and ended up getting a yeast infection. I went back to the clinic where they have me a 3 day course of Terconazole, it helped but didn't clear the infection completely. Such a pain! So back to the clinic I went where they gave me 2 doses of Fluconazole, one to take right away and another to take 3 days later. I didn't notice an immediate improvement like many of these other reviews. About 24 hours after taking the first dose I noticed a lot of prickling down there, kind of like sandpaper. The prickling lasted for about a week before it finally started to fade. I went back to the clinic 10 days later to make sure the infection was gone, and they finally couldn't find any yeast! I still feel a bit sore and scratchy, but at least I know it is from the infection healing and not more yeast. Didn't have any major side effects, just felt really tired after a few days. Overall Im happy with Fluconazole, but the curing and healing process is very gradual.”

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Anonymous September 17, 2015

For Vaginal Yeast Infection: “Ok so I had a yeast infection for a whole month it was some type of intense burning sensation in my vagina it was sooo bad it went and came every other day it had gotten so bad I had to see a doctor. I was scared because it was so bad and I cried and thought I would never have a sex life ever again. I went to an obgyn in he told me I had a mild yeast infection I was shocked because it felt so severe and painful. I thought it was something worse the doctor prescribed me diflucan/flicanzole 150mg. It was one pill I took it when I got home. It didn't work instantly but the yeast was fixed in two days. I took it on Tuesday & felt nothing Thursday morning - I was so happy ”

10 / 10
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More FAQ

Jen0620 June 27, 2013

For Vaginal Yeast Infection: “It is unbelievable how wonderful this medicine is for yeast infections! I went to doc for a urinary tract infection and also had symptoms of redness, burning, itching and swelling. It was the worst ever! Took 1 pill and already noticed results in just a few hours! It is a miracle.”

10 / 10
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girlproblems · Taken for 6 months to 1 year July 26, 2018

For Vaginal Yeast Infection: “So I’ve taken this medicine in the past (prone to yeast but now cutting back on sugar consumption, finally caught on). I want to say as of 2017 some ingredient HAD to change with this medication . Took it in the fall of 2017 the following day my lip itches and turns red. Took it in January 2018 the following day my lip itched , turned red and actually scabbed up as well as part of my cheek. Got tested everything came out clear. Started thinking it could’ve been the medicine at that time but wasn’t sure. Now it July I took the one time pill again, woke up the next morning and guess who’s lip and cheek was red ...it lasts a few days & literally happens in the same spot each time.. has anyone else noticed a change taking this?”

5 / 10
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Hopefully helpful December 17, 2015

For Vaginal Yeast Infection: “Ladies, I read some comments on here I wanted to respond to. If you've been taking the diflucan pill more than once and you're still experiencing pain and discomfort you might actually have bacterial vaginosis The symptoms are very similar and sometimes yeast infection medicine can cause this. You will need a different prescription to clear this up. Just a thought to consider if your symptoms are not clearing up. Think about making a visit to the doctor to find out.”

8 / 10
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Sakura · Taken for 2 to 5 years February 25, 2020

For Vaginal Yeast Infection: “So this is probably very TMI but here goes. I’ve been taking diflucan for about 3 years now. I have recurrent yeast infections due to being immunocompromised. Last year I had 9 infections. I am allergic to all over the counter yeast medicines. My labia minora is always inside my body, the over the counter medication causes my labia to come outside of my body and swell to the size of bigger than a golf ball. This medication saves me so much. When I take it, it’s like magic. I notice improvement within an hour. Usually only takes a day and it’s gone completely. Before I knew of it’s existence I would use Apple cider vinegar. Don’t do that. It burns bad. It killed the yeast but started giving me BV. So thankful for this medication.”

10 / 10
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Juju61406 · Taken for less than 1 month June 9, 2016

For Vaginal Yeast Infection: “I was diagnosed with a Yeast Infection for the first time yesterday morning after 2 days of discomfort. My vulva was swollen, sore & itchy & my vagina was extremely sore & it burned slightly. After I saw cottage cheese-like discharge in my underwear on yesterday morning I decided it was time to take action & I went to my doctor. I was given one pill (150 Mmg dose of Diflucan) by my doctor. I took the pill at around 10:30am & later on last night I began to feel relief! This morning around 7am I woke up feeling almost 100% relieved!! Not even a full 24 hours & this medicine gave me relief! I can still feel slight itching a little bit throughout my day, but I'm sure in a couple of days I'll be back to normal & yeast infection free by Tuesday!”

10 / 10
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Thaddius She Is · Taken for less than 1 month August 20, 2019

For Vaginal Yeast Infection: “This worked great for me. Before taking the pill I was itching and burning and had discharge. I was so embarrassed because I never had one before. I also started to develop ulcers in my mouth so the infection actually reached my mouth since it went untreated for 3 weeks. I was prescribed Diflucan. I took it on Friday by Sunday I started to feel better. On Sunday I took the second pill. It is now Tuesday and my tongue ulcers are healing, my tonsils have gone down, The itching and burning stopped but the irritation is still there whenever I wash my vagina with soap or wear certain panties.”

10 / 10
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begone itch · Taken for less than 1 month January 19, 2019

For Vaginal Yeast Infection: “I asked my doctor for a prescription of diflucan after monistat 7 burned my insides worse than the infection itself! Diflucan has been great for me so far!! I was prescribed two 150mg tablets— one to take ASAP, and the other to take three days later. I’m on day 2 of the pill being in my system, and let me tell you, although it takes a while for the pill to kick in, it really does work!!! Now, this didn’t work a mere couple hours later for me, I didn’t start to feel relief until this morning, but a little over 24 hours after ingesting the pill, and the burning has completely gone away :) the itchiness is still prevalent, although it has subsided GREATLY. I’m still a bit sore, but that’s to be expected with a really bad yeast infection. The only side effects that I’ve really noticed with this pill are that it did leave a small patch of dry skin near my mouth (but as an eczema sufferer, this is nothing crazy for me to handle lol), and it really will give you the poops.”

8 / 10
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mongasb April 14, 2009

For Onychomycosis, Toenail: “I had terrible toenail fungus for many years. I participated in a double blind study of Diflucan for toenail fungus, and it was like a miracle. Month by month the fungus disappeared. Each month, I had blood work done. There was never a change in my liver function studies. It has been 10 years and the fungus has never reappeared.”

10 / 10
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On The Mend January 10, 2016

For Vaginal Yeast Infection: “Diflucan works freaking miracles; I'm never using OTC creams again. Last month (after a round of antibiotics) I developed a mild yeast infection and used Monistat One Day to clear it up. Unfortunately, I should've listened to other reviewers about Monistat because, this month before my period, the infection came back with vengeance! I called up my doctor and got a prescription for the genetic 200mg Diflucan. This drug is a heaven send! I took it with food at 5pm, and by 7pm, I was already feeling better. The discharge was firming up and exiting my body, the itching was lessening, and the discomfort of my labia was improving. No discomfort, burning, or messy creams with this medication. Why deal with Monistat when Diflucan is an option?”

10 / 10
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Nicki34786 · Taken for less than 1 month January 10, 2021

For Vaginal Yeast Infection: “I took Diflucan years ago for a yeast infection—got rid of it quickly and efficiently with no side effects! Fast forward to this year. I had a major yeast infection, took Diflucan but this time had multiple weird side effects, including: peeling/swollen lips (with ulcers on the inside), nausea/vomiting, terrible stomach pains and diarrhea, heart palpitations, itchy throat and increased vaginal and anal irritation. I even developed hemorrhoids for the first time in my life, and I attribute it all to this drug. I think it severely irritated my mucous membranes and then this was only worsened by coupled chronic diarrhea I was having. Be really careful taking this drug..it’s no joke.”

1 / 10
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'schell · Taken for less than 1 month August 7, 2014

For Vaginal Yeast Infection: “After having a urinary tract infection for three weeks, & three different antibiotics, with the third being Bactrim, I developed a horrible yeast infection. Thank goodness my Dr. prescribed seven days worth of Diflucan. After one pill, I experienced relief. Not complete relief, but I could finally get some sleep. Before Diflucan, I went through two tubes of Vagisil. It works but there is a perfumy smell that clings to the body. If my Dr. had only prescribed one pill I would be back in the ER begging for something to relieve the maddening itch. This is my first yeast infection & I hope I never get another!”

8 / 10
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Lindseylovely · Taken for 10 years or more July 23, 2020

For Oral Thrush: “Diflucan had no side effects for me. Taken this like a million times. For thrush, vagina yeast infection, skin yeast infection, and athletes foot. Wait it out with the results of the pill. It's not instant, it takes 24- 48 hrs to work and then it is better quickly. If you need instant relief, use cream or antifungal mouthwash immediately and then take the pill. Only reason I didn't give 10 stars is you never know how many you need to take. I stick with 3 each time as that seems to do the trick.”

9 / 10
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Rivalry · Taken for 6 months to 1 year November 26, 2019

For Vaginal Yeast Infection: “I am prone to yeast infections. Not super prone. But I usually get about 3 yeast infections a year, more if I have infections that require antibiotics. Rarely does over the counter medication work for me, plus I just hate how gross, messy, and how long it takes to clear up with the over the counter suppositories. This medication Diflucan is really a god send because the minute I feel it coming on I take it and symptoms are gone super quickly and with NO MESS. I honestly don't notice any side effects. I might get an upset stomach but I usually get that from the antibiotics that give me the yeast infection to begin with.”

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Anonymous October 19, 2012

For Vaginal Yeast Infection: “I have suffered every month, for years with a yeast problem. Avoiding sex, chocolate and wine were hardly a solution for me! These are the important ingredients you should be taking: 1. Eat yogurt & cereal on an empty stomach. 2. Take an acidophillus supplement. This made me NORMAL. Hooooray!”

8 / 10
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Anna9981 April 24, 2016

For Vaginal Yeast Infection: “I took a single dose Diflucan a few days ago after developing an agonizing yeast infection, thanks to round of antibiotics, compiled with an allergic reaction to a product I had used called Yeastaway (never again!). Once the Diflucan kicked in- boy, did it work- it was like night and day. By the hour, the swelling, itching, and discharge was going down. I went from pure itching hell (tearing apart the freezer looking for something to ease the agony) the night before to a calm, restful night the following day. I've never noticed any negative physical side effects. My only frustration was that this took 2.5 solid days to start working... topical creams made me itch more, and I started to wonder if the Diflucan would ever work at all.”

8 / 10
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The Wine Lady · Taken for 1 to 2 years December 20, 2015

For Vaginal Yeast Infection: “DO NOT DRINK if you take this medication. The alcohol makes it not work. I had no idea and I like my wine. A Dr friend of mine told me that alcohol could be affecting the drug. Anytime I have ever tried to drink and take this it doesn't work. If I don't drink at all when I take it.. It works like magic. If you have had a problem with it not working make sure you're not drinking. Even one drink has made it not work as well for me. It literally is a lifesaver.”

9 / 10
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Bre June 17, 2019

For Vaginal Yeast Infection: “I originally had a UTI and was prescribed antibiotics for 5 days. About two days later I started itching and the doctor prescribed me this drug. I kid you not I was sooooooooo dizzy I thought I was going to fall over. It didn't matter if I was standing up or sitting down. The dizziness was freaking horrible. Oh, I only had one dose of it and I'm still itching like crazy”

5 / 10
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Jillybean2015 November 18, 2016

For Vaginal Yeast Infection: “First off, I looked in here to see when it was best to take the pill. My doctor Always prescribes me one "Just in case" Whenever he give me antibiotics.... But the first thing i saw was how much people are spending on these.... There is an app called good Rx.com that I usually get coupons from for the more EXPENSIVE prescriptions BUT at ALL Walmart stores Diflucan is $4.00! PERIOD!!!!! SAME AS ANTIBIOTICS..... JUST TELL THEM DO NOT RUN YOUR INSURANCE. HOPE THAT HELPS! :)”

10 / 10
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Ethi July 17, 2019

For Vaginal Yeast Infection: “This is my second time taking Diflucan. I had an allergic reaction to medication. My reaction was not listed as their side effects. I instantly started having stinging in my lips. Later that day my lips were swollen. My tonsils started to get sore. My vagina is swollen, extreme itching, and painful. It made me develop hemorrhoids. It has been two days and my symptoms are worse. I am athletic and drink a lot of water. I should’ve never developed hemorrhoids. The itching is unbearable. I am now using otc creams for the discomfort. I’ve had STD testing for HIV, Gonorrhea, Chylmidia, RPR, and HSV. Everything was negative. Be cautious of this medication.”

1 / 10
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CrystalMcFar31 · Taken for less than 1 month July 30, 2019

For Vaginal Yeast Infection: “Was prescribed this medication after BV treatment and next day lip was swollen & itching. Lip swelled to the point it was tight and shiny. Eating was unbearable. Woke up with a blister that has since popped and now I have open sore and scabs. I WILL NOT EVER TAKE THIS MEDICATION AGAIN!”

1 / 10
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Anonymous May 4, 2014

For Vaginal Yeast Infection: “I too had a rash close to my vagina, a pretty bad one & my gynecologist said it was bacterial vaginosis along with a yeast infection. It was my 1st infection so I had no idea what was going on. She prescribed me metronidazole 500 mg for 7 days, on day 4 I took Diflucan 1, on day 7 I took another Diflucan 1, three days later I took my last one. I didn't start seeing results until I was taking both medications together. For those of you who have to pay for your medicine go on their website they have a $5 off coupon.”

8 / 10
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This information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners.