Diflucan and Allergic Reaction: What Users Say

• Sak...
• Taken for 2 to 5 years
• February 25, 2020

For Vaginal Yeast Infection "So this is probably very TMI, but here goes. I’ve been taking Diflucan for about 3 years now. I have recurrent yeast infections due to being immunocompromised. Last year, I had 9 infections. I am allergic to all over-the-counter yeast medicines. My labia minora is always inside my body, the over-the-counter medication causes my labia to come outside of my body and swell to the size of bigger than a golf ball. This medication saves me so much. When I take it, it’s like magic. I notice improvement within an hour. It usually only takes a day, and it’s gone completely. Before I knew of its existence, I would use apple cider vinegar. Don’t do that. It burns bad. It killed the yeast but started giving me BV. So thankful for this medication."

• hap...
• Taken for less than 1 month
• March 21, 2017

For Vaginal Yeast Infection "I had what felt like a moderate yeast infection. I was given Terazole 3 at first but had the most horrible allergic reaction that made my yeast infection symptoms increase 100 times. I have never felt misery like that in my life, it felt like my insides and outsides were trying to kill me. I was switched to the single dose of 150 mg Diflucan, and my symptoms improved by half within 24 hours and only got better from there. It took about a week for all discomfort (including the occasional minor itch) to completely disappear."

• Sev...
• Taken for less than 1 month
• January 25, 2017

For Vaginal Yeast Infection "I have taken this medication before, so not sure if something with my body chemistry changed or this medication composition has changed. My experience was a severe allergic reaction causing swelling to my face and lips, with blistering and sores inside my mouth that were extremely painful. I was given a steroid shot and high dosages of prednisone. On day 5, the swelling has just started to go down, but the sores inside my mouth and the scabs on my lips are horrible. I will not take this medication again."

• Eth...
• July 17, 2019

For Vaginal Yeast Infection "This is my second time taking Diflucan. I had an allergic reaction to the medication. My reaction was not listed as their side effects. I instantly started having stinging in my lips. Later that day, my lips were swollen. My tonsils started to get sore. My vagina is swollen, with extreme itching, and painful. It made me develop hemorrhoids. It has been two days, and my symptoms are worse. I am athletic and drink a lot of water. I should’ve never developed hemorrhoids. The itching is unbearable. I am now using OTC creams for the discomfort. I’ve had STD testing for HIV, Gonorrhea, Chlamydia, RPR, and HSV. Everything was negative. Be cautious of this medication."

• Kik...
• Taken for 2 to 5 years
• September 7, 2019

For Vaginal Yeast Infection "Have taken sporadically for a yeast infection. Seemed to work, but I broke out in hives. It took me a bit to figure it out because I’d take 1 pill maybe once a year. It didn’t register. Well, now I know! I took 1 pill in March, 1 pill in July, and thought, huh, I wonder if fluconazole. Took 1 pill yesterday and paid attention!!! Yep! Ugh! Hives and allergic reaction not on the list! I get hives, my knuckle swells on 1 finger, and it is painful. It blisters and finally pops and heals on its own. Each time it is worse. Now my lips are swollen, and hives on palms and on skin by thumb. My hands are so dry. NEVER AGAIN WILL I TAKE THIS fluconazole!!"

• FDE...
• May 14, 2019

For Vaginal Yeast Infection "I took Diflucan last year, and my vaginal yeast infection cleared up in a day, no allergic reactions. I recently needed to take it again earlier this year, and my upper lip became swollen with a tiny sore/blister on the underside of my lip. The right side of my face was also slightly swollen and numb. The pharmacist didn’t think it was related to Diflucan because I hadn’t had a reaction before. Well, was she wrong! I had to take it again a couple of days ago, and the exact allergic reaction returned (which I realize is most likely a Fixed Drug Eruption). This time, my upper lip is much worse, with a sore in the same spot, and it’s taking longer to disappear. Both times I’ve been taking antihistamines to help. If you experience an allergic reaction after taking Diflucan, think very carefully about taking it again."

• bla...
• January 5, 2011

For Candidemia "I recently found out that I'm allergic to fluconazole. I have been taking this medication for years with no side effects, but within the last year, every time I take it, my lip swells and feels like ants or needles are in it. Then my lip will get like a cold sore on it, and after it heals, it remains black."

• Lin...
• Taken for less than 1 month
• August 9, 2022

For Vaginal Yeast Infection "I am always prescribed this drug when I get a yeast infection. The past 3 times I have taken it, it causes a couple of my fingers to swell and itch. By the next day, I always have a blister on my finger! I have developed an allergy to this medication. I will never take it again!!!"