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Azole antifungals

What are Azole antifungals?

Azole antifungals are a group of medicines that contain an azole ring and inhibit the growth of a wide range of fungi. They are classified into two groups: those with two nitrogens in the azole ring (the imidazoles; examples include clotrimazole, econazole, ketoconazole, miconazole, and tioconazole) and those with three nitrogens in the azole ring (the triazoles; examples include fluconazole, itraconazole, posaconazole, and voriconazole).

Azole antifungals work by inhibiting the cytochrome P450 dependent enzyme lanosterol 14-alpha-demethylase, which converts lanosterol to ergosterol, the main sterol in the fungal cell membrane. Depletion of ergosterol damages the cell membrane resulting in cell death.

Azole antifungal agents can be used to treat fungal infections of the body and skin, including athlete's foot, onychomycosis (fungal nail infections), ringworm, and vaginal candidiasis.

List of Azole antifungals:

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Drug Name Reviews Avg. Ratings
Vfend (Pro)
Generic name: voriconazole
2 reviews
Sporanox (Pro)
Generic name: itraconazole
15 reviews
Noxafil (Pro)
Generic name: posaconazole
1 review
Diflucan (Pro)
Generic name: fluconazole
122 reviews
Nizoral (Pro)
Generic name: ketoconazole
4 reviews
Mycelex Troche
Generic name: clotrimazole
5 reviews
Cresemba (Pro)
Generic name: isavuconazonium
1 reviewAdd rating
Onmel (Pro)
Generic name: itraconazole
0 reviewsAdd rating
Oravig (Pro)
Generic name: miconazole
0 reviewsAdd rating
Tolsura (Pro)
Generic name: itraconazole
0 reviewsAdd rating

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.