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Azole antifungals

What are Azole antifungals?

Azole antifungals are a group of medicines that contain an azole ring and inhibit the growth of a wide range of fungi. They are classified into two groups: those with two nitrogens in the azole ring (the imidazoles; examples include clotrimazole, econazole, ketoconazole, miconazole, and tioconazole) and those with three nitrogens in the azole ring (the triazoles; examples include fluconazole, itraconazole, posaconazole, and voriconazole).

Azole antifungals work by inhibiting the cytochrome P450 dependent enzyme lanosterol 14-alpha-demethylase, which converts lanosterol to ergosterol, the main sterol in the fungal cell membrane. Depletion of ergosterol damages the cell membrane resulting in cell death.

Azole antifungal agents can be used to treat fungal infections of the body and skin, including athlete's foot, onychomycosis (fungal nail infections), ringworm, and vaginal candidiasis.

List of Azole antifungals

View by  Brand | Generic
Drug Name Avg. Rating Reviews
Diflucan (Pro)
Generic name: fluconazole
144 reviews
Sporanox (Pro)
Generic name: itraconazole
19 reviews
Mycelex Troche
Generic name: clotrimazole
7 reviews
Nizoral (Pro)
Generic name: ketoconazole
4 reviews
Vfend (Pro)
Generic name: voriconazole
3 reviews
Cresemba (Pro)
Generic name: isavuconazonium
2 reviews
Noxafil (Pro)
Generic name: posaconazole
1 review
Vivjoa (Pro)
Generic name: oteseconazole
No reviews
Tolsura (Pro)
Generic name: itraconazole
No reviews
Oravig (Pro)
Generic name: miconazole
No reviews
Onmel (Pro)
Generic name: itraconazole
No reviews
For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.