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Generic name: oteseconazole [ oh-TES-e-KON-a-zole ]
Brand name: Vivjoa
Dosage form: oral capsule (150 mg)
Drug class: Azole antifungals

Medically reviewed by on Sep 27, 2022. Written by Cerner Multum.

What is oteseconazole?

Oteseconazole is used to reduce the risk of vaginal yeast infections that keep coming back.

Oteseconazole should only be taken by women who are not pregnant and who are not able to get pregnant.

Oteseconazole may also be used for purposes not listed in this medication guide.

Oteseconazole side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Common side effects of oteseconazole may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Do not use if you are pregnant or plan to get pregnant, or breastfeeding or plan to breastfeed.

Before taking this medicine

You should not use oteseconazole if you are allergic to it, or if you:

  • are able to get pregnant;

  • are pregnant or plan to get pregnant; or

  • are breastfeeding or plan to breastfeed.

Tell your doctor if you have ever had:

  • liver or kidney disease.

May harm an unborn baby. Tell your doctor if you are pregnant, think you might be pregnant, or plan to get pregnant.

Do not breastfeed while using oteseconazole.

Not approved for use in females who have not had their first menstrual period.

How should I take oteseconazole?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.

Oteseconazole can be taken alone or given together with another medicine called fluconazole. Your doctor will determine the proper treatment. Use the medicine exactly as directed.

Take with food.

Swallow the capsule whole and do not crush, chew, break, or open it.

Store at room temperature away from moisture, heat, and light.

Oteseconazole dosing information

Usual Adult Dose for Vaginal Candidiasis:

There are 2 recommended dosage regimens, and only one should be used:

Oteseconazole-Only Dosage Regimen:
-Day 1: 600 mg orally as a single dose
-Day 2: 450 mg orally as a single dose
-Beginning on Day 14: 150 mg orally once a week (every 7 days) for 11 weeks (weeks 2 through 12)
-Duration of therapy: 12 weeks

Oteseconazole and Fluconazole Dosage Regimen:
-Day 1, Day 4 and Day 7: Administer Fluconazole orally (should be prescribed separately)
-Day 14 to 20: Administer Oteseconazole 150 mg orally once a day for 7 days
-Beginning of Day 28: Administer Oteseconazole 150 mg once a week (every 7 days) for 11 weeks (weeks 4 to 14)
-Duration of therapy: 14 weeks

Use: Recurrent Vulvovaginal Candidiasis (RVVC) in females with a history of RVVC who are NOT of reproductive potential

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking oteseconazole?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect oteseconazole?

Other drugs may affect oteseconazole, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.