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Diflucan and Swelling: What Users Say

Swelling: mentioned by 12 users (8.3%)

Based on user experiences from 144 Diflucan reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

itching 20.8%
burning 11.1%
dizziness 11.1%
swelling 8.3%
headaches 7.6%
nausea 7.6%
allergic reaction 5.6%
blisters 4.9%
pain 4.9%
rash 4.2%

Reviews for Diflucan

Commonly mentioned side effects
  • Jen...
  • June 27, 2013

For Vaginal Yeast Infection "It is unbelievable how wonderful this medicine is for yeast infections! I went to the doctor for a urinary tract infection and also had symptoms of redness, burning, itching, and swelling. It was the worst ever! Took 1 pill and already noticed results in just a few hours! It is a miracle."

10 / 10
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187 Report
  • Chi...
  • Taken for less than 1 month
  • May 27, 2020

For Candida Urinary Tract Infection "Okay, umm... I was diagnosed with candida in 2014 and was given different antifungals, which seemed to work for the meantime. Then, in 2015, I had a reinfection, symptoms were similar to the last one. So, Diflucan was recommended: 150 mg single dose and ketoconazole cream. On taking the single dose of Diflucan, I got a lot better after 3 hours, it was such a relief. The itching, burning, and inflammation stopped. This is 2020, and I am currently on another dose, and it's working perfectly... I recommend this drug 100%."

10 / 10
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30 Report
  • Sev...
  • Taken for less than 1 month
  • January 25, 2017

For Vaginal Yeast Infection "I have taken this medication before, so not sure if something with my body chemistry changed or this medication composition has changed. My experience was a severe allergic reaction causing swelling to my face and lips, with blistering and sores inside my mouth that were extremely painful. I was given a steroid shot and high dosages of prednisone. On day 5, the swelling has just started to go down, but the sores inside my mouth and the scabs on my lips are horrible. I will not take this medication again."

1 / 10
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43 Report

See also:

Frequently asked questions

  • Kik...
  • Taken for 2 to 5 years
  • September 7, 2019

For Vaginal Yeast Infection "Have taken sporadically for a yeast infection. Seemed to work, but I broke out in hives. It took me a bit to figure it out because I’d take 1 pill maybe once a year. It didn’t register. Well, now I know! I took 1 pill in March, 1 pill in July, and thought, huh, I wonder if fluconazole. Took 1 pill yesterday and paid attention!!! Yep! Ugh! Hives and allergic reaction not on the list! I get hives, my knuckle swells on 1 finger, and it is painful. It blisters and finally pops and heals on its own. Each time it is worse. Now my lips are swollen, and hives on palms and on skin by thumb. My hands are so dry. NEVER AGAIN WILL I TAKE THIS fluconazole!!"

1 / 10
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33 Report
  • FDE...
  • May 14, 2019

For Vaginal Yeast Infection "I took Diflucan last year, and my vaginal yeast infection cleared up in a day, no allergic reactions. I recently needed to take it again earlier this year, and my upper lip became swollen with a tiny sore/blister on the underside of my lip. The right side of my face was also slightly swollen and numb. The pharmacist didn’t think it was related to Diflucan because I hadn’t had a reaction before. Well, was she wrong! I had to take it again a couple of days ago, and the exact allergic reaction returned (which I realize is most likely a Fixed Drug Eruption). This time, my upper lip is much worse, with a sore in the same spot, and it’s taking longer to disappear. Both times I’ve been taking antihistamines to help. If you experience an allergic reaction after taking Diflucan, think very carefully about taking it again."

1 / 10
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24 Report

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  • FDE...
  • May 14, 2019

For Vaginal Yeast Infection "I took Diflucan last year, and my vaginal yeast infection cleared up in a day, no allergic reactions. I recently needed to take it again earlier this year, and my upper lip became swollen with a tiny sore/blister on the underside of my lip. The right side of my face was also slightly swollen and numb. The pharmacist didn’t think it was related to Diflucan because I hadn’t had a reaction before. Well, was she wrong! I had to take it again a couple of days ago, and the exact allergic reaction returned (which I realize is most likely a Fixed Drug Eruption). This time, my upper lip is much worse, with a sore in the same spot, and it’s taking longer to disappear. Both times I’ve been taking antihistamines to help. If you experience an allergic reaction after taking Diflucan, think very carefully about taking it again."

1 / 10
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24 Report
  • Cry...
  • Taken for less than 1 month
  • July 30, 2019

For Vaginal Yeast Infection "Was prescribed this medication after BV treatment, and the next day, lip was swollen & itching. Lip swelled to the point it was tight and shiny. Eating was unbearable. Woke up with a blister that has since popped, and now I have an open sore and scabs. I WILL NOT EVER TAKE THIS MEDICATION AGAIN!"

1 / 10
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32 Report

More FAQ

  • Ej9...
  • August 2, 2017

For Vaginal Yeast Infection "I suffer from yeast infections quite frequently, especially while being on my depo birth control shot and being more sexually active. In the past, Diflucan did the trick in 24 hours (I learned Monistat does NOTHING for me!). As I suffer from them almost every other month, if not every month, I believe I have built a resistance to the medication. I began needing two pills prescribed at a time for an effective solution. Just a few days ago, I received a pack of 3. My symptoms feel almost worse than before getting the prescription. I didn't drink much water and also had sex after taking the pill day 2, but I took the last pill yesterday, and my vagina is raw and swollen as well as itchy. I also feel my period beginning. I hate this confusion about my body."

7 / 10
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35 Report
  • bla...
  • January 5, 2011

For Candidemia "I recently found out that I'm allergic to fluconazole. I have been taking this medication for years with no side effects, but within the last year, every time I take it, my lip swells and feels like ants or needles are in it. Then my lip will get like a cold sore on it, and after it heals, it remains black."

4 / 10
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33 Report
  • Lin...
  • Taken for less than 1 month
  • August 9, 2022

For Vaginal Yeast Infection "I am always prescribed this drug when I get a yeast infection. The past 3 times I have taken it, it causes a couple of my fingers to swell and itch. By the next day, I always have a blister on my finger! I have developed an allergy to this medication. I will never take it again!!!"

1 / 10
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7 Report
  • itc...
  • February 13, 2016

For Vaginal Yeast Infection "I have been miserable. Took a one dose of Diflucan last night, and I can say swelling is less, but everything else that is awful is still there. But, wine lady, please don't tell me I can't drink wine. I'm almost finished with my glass when I read your review.... Should I take another one-time dose? I'm way too old for this!!"

4 / 10
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18 Report
  • Nan...
  • Taken for less than 1 month
  • January 1, 2019

For Vaginal Yeast Infection "I reacted strongly. I was red and itchy all over my body. My hands and mouth were swollen. I think it was an allergy."

1 / 10
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11 Report

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