Diflucan (fluconazole) Drug Interactions
A total of 726 drugs are known to interact with Diflucan (fluconazole).
- 179 major drug interactions
- 472 moderate drug interactions
- 75 minor drug interactions
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Most frequently checked interactions
View interaction reports for Diflucan (fluconazole) and the medicines listed below.
- amoxicillin (Amoxil, Trimox, Apo-Amoxi, Amoxicot, Moxatag, DisperMox, Moxilin, Wymox, Biomox)
- Bactrim (sulfamethoxazole / trimethoprim)
- Benadryl (diphenhydramine)
- Cipro (ciprofloxacin)
- Coumadin (warfarin)
- Cymbalta (duloxetine)
- doxycycline (Vibramycin, Oracea, Monodox, Doxy 100, Doryx, Adoxa, Targadox, Morgidox, Acticlate, Vibra-Tabs, Doxy-Caps, Periostat, Doxy 200, Oraxyl, Doryx MPC, Doxy-D, Alodox, Adoxa Pak, Avidoxy, Adoxa TT, Adoxa CK, Ocudox, LymePak, Uracil, Mondoxyne NL, NicAzel Doxy, Doxy-Lemmon)
- Flagyl (metronidazole)
- Flonase (fluticasone nasal)
- gabapentin (Neurontin, Gralise, Gabarone, Fanatrex)
- ibuprofen (Advil, Motrin, IBU, Children's Motrin, Proprinal, Advil Liqui-Gels, Ibu-8, Motrin IB, Motrin Childrens, Rufen, Childrens Ibuprofen Berry, IBU-200, Ibuprofen PMR, Advil Migraine, Ibu-Tab, Genpril, Menadol, Advil Children's, Midol Maximum Strength Cramp Formula, Motrin Migraine Pain, Addaprin, Motrin Infant Drops, NeoProfen, Caldolor, Motrin Pediatric, Haltran, Midol IB, Saleto-200, Q-Profen, Saleto-400, Saleto-600, Saleto-800, A-G Profen, Nuprin, Advil Junior Strength, Actiprofen, PediaCare Infants' IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-4, PediaCare Children's IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-6, Motrin Junior Strength, Help I Have An Aching Body, Children's ElixSure IB, Advil Infant's Concentrated Drops, Cap-Profen, Advil Film-Coated)
- Keflex (cephalexin)
- Levaquin (levofloxacin)
- Lexapro (escitalopram)
- lisinopril (Zestril, Prinivil, Qbrelis)
- metformin (Glucophage, Glumetza, Glucophage XR, Fortamet, Riomet)
- metronidazole (Flagyl, Flagyl IV, Metro, Flagyl ER, Flagyl 375, Metro IV, Protostat, Metryl)
- Monistat (miconazole topical)
- nystatin (Mycostatin, Nilstat, Bio-Statin, Nystat-Rx, Mycostatin Pastilles, Nystex)
- omeprazole (Prilosec, Prilosec OTC, Zegerid (Original Formulation), Omesec)
- oxycodone (OxyContin, Roxicodone, Xtampza ER, OxyIR, Oxaydo, RoxyBond, Percolone, Oxecta, Oxydose, Oxyfast, M-Oxy, ETH-Oxydose, Endocodone, Roxicodone Intensol, Dazidox)
- Plan B (levonorgestrel)
- prednisone (Deltasone, Rayos, Sterapred, Prednicot, Sterapred DS, Meticorten, Orasone, Liquid Pred, Prednicen-M)
- Singulair (montelukast)
- Synthroid (levothyroxine)
- tramadol (Ultram, Tramadol Hydrochloride ER, Tramal, Ultram ER, ConZip, Zydol, Tramal SR, GenRx Tramadol, Zamadol, Ryzolt, Tramedo, Larapam SR, Tramahexal SR, Tramahexal, Zydol XL, Rybix ODT, Ultram ODT)
- Tylenol (acetaminophen)
- Vitamin B12 (cyanocobalamin)
- Vitamin D3 (cholecalciferol)
- Xanax (alprazolam)
- Zofran (ondansetron)
- Zoloft (sertraline)
- Zyrtec (cetirizine)
Diflucan (fluconazole) disease interactions
There are 4 disease interactions with Diflucan (fluconazole) which include:
More about Diflucan (fluconazole)
- Diflucan Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Images
- Compare Alternatives
- Support Group
- Pricing & Coupons
- En Español
- 106 Reviews
- Generic Availability
- Drug class: azole antifungals
- FDA Alerts (3)
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
