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User Reviews for Cymbalta to treat Chronic Pain (Page 2)

Cymbalta has an average rating of 5.9 out of 10 from a total of 141 ratings for the treatment of Chronic Pain. 52% of those users who reviewed Cymbalta reported a positive effect, while 33% reported a negative effect.

Cymbalta Rating Summary

5.9/10 average rating

141 ratings from 147 user reviews.

Compare all 50 medications used in the treatment of Chronic Pain.


Reviews for Cymbalta

Chip · Taken for 1 to 6 months March 17, 2021

“Started taking this for pain, over a four month period, with gradual increases up to 120 mg. It gave me severe, severe depression, and made me feel like I wasn’t myself at all. I also had brain frog, and almost 10 lbs weight gain even though it gor rid of my appetite. A lot of water retention especially around my lower abdomen. It also gave me poor sleep and terrifying nightmares. Weaning off now with a schedule from my doctor. I would not only not recommend this drug, but if it must be tried, to talk to your doctor weekly about your moods and feelings in case you start to feel depressed; or worse.”

1 / 10
Adub0614 · Taken for 1 to 6 months August 29, 2017

“I suffer from chronic pain, depression and anxiety for the past 10 years and I'm 30. Football ruined my life, but cymbalta has made it worse. Not only did I NOT receive any benefit from cymbalta but I gave it the a serious 2 month try and I'm not spending 90% of my time withdrawing from it. I cannot imagine if I was on this a year, let alone ten. If this medicine helps you, I would weigh the benefits seriously- because either you're going to the grave with this medicine or you're going to have to feel the "benefits" of coming off of this poison. Beware.. because no doctor will tell you these things. Worse than 2 years of clonazepam, alcohol, or opiates... no joke. Hope this helps someone!”

1 / 10
Baloo789 June 8, 2013

“After suffering in a very serious way from chronic neck and back pain for about 5 years, I was giving up. I had no major injury, but small "normal range" disc ruptures protruding in my C5 and C7 with other old back injuries. Fibromyalgia/Neuralgia. I've gone through multiple specialists, MRIs, physical therapists, chiropractors, and acupuncturists. Some relief here and there, mostly with acupuncture and specific stretching. Pain was horrible. Finally after persistent research, I found what truly works for me: Cymbalta (normal dose) with daily SAM-E and Malic Acid supplements. It took about 2 months to fully work, but now I'm virtually PAIN FREE. Cannot thank God enough for this.”

8 / 10

Frequently asked questions

Queenie · Taken for less than 1 month March 7, 2021

“After being on Paxil for over 25 years for anxiety/panic attacks but as I age I have ankle and leg pain. So between the dr and I we thought I should try Cymbalta. So straight to cymbalta 30 mg from 20 mg Paxil. What a nightmarish week no appetite, nausea, throwing up, severe headaches, weakness, tight chest and every side effect listed. Thank the lord I do not work anymore cause there is no way a person could function like that at work. Day 5 called Dr to see what I should do to get off cymbalta, that I’m done. She said just start taking Paxil again. Day two Paxil still trying to get that horrible cymbalta med out of me. Using milk thistle and B complex. Please read all the side effects. Liver and brain damage! Any drinking alcohol has a very high risk of liver damage. High blood pressure also. Do your research ... very scary mind altering drug.General med Drs really need to study more about the horrible withdrawal side effects and side effects of new antidepressants.”

1 / 10
Lucy · Taken for 1 to 6 months February 26, 2021

“Cymbalta helped a LOT with chronic pain as well as anxiety. I feel so much better with this medication! I feel mental clarity and the constant irritability from chronic pain was completely relieved. I wish I had tried this years ago! I realize not everyone has the same experience with medications but my quality of life has increased significantly! I have nerve pain that has almost totally gone away!”

10 / 10
Crps warrior · Taken for 1 to 6 months January 15, 2021

“Only on it for six weeks, I was a depressed zombie for three of them, lost all ability to function and could barely get out of bed. Talk about a numbing drug. All these meds are toxic, get back to nature and heal properly.”

1 / 10
Swampy October 6, 2019

“I was given duloxetine to help with depression and pain after I revealed to my psych that I feel random aches and pains nearly all the time. First day taking it was hard - terrible stomach pain and diarrhea. But, after that my tummy settled. I am at 90mg and I no longer notice these random pains that I got for no reason. It's great to be comfortable. I cannot comment as to whether it helps with my depression as I take a few different meds for that.”

10 / 10

More FAQ

plkc2244 June 21, 2016

“I have been on Cymbalta for 5 years. I am bipolar and found it to be an excellent SSRI for depression. I also have osteoarthritis with 2 replaced knees before 50 years old. My meds were being changed around (which we do now and then for efficacy) and I came off the Cymbalta. By day 2 I was in agony. Every joint in my body ached and I was in terrible pain. I went back to my Psychiatrist and by that point he had heard about the connection. I went back on Cymbalta and by day 2 I was up and working in the garden just like before. Absolutely no pain.”

Kelly H714 · Taken for less than 1 month May 21, 2016

“I've been in chronic pain for YEARS..just the other day I took worked the first day..unbelievable I was amazed.I read a ton of bad reviews so I was sceptical. But it worked..I dont have to take any pain meds at all. I have fibromyalgia small fiber nuropothy degenerative disc disease osteoarthritis lupus..”

10 / 10
FlyGuyRA November 24, 2016

“I've had RA for 56 years, and of course pain. Before having my gastric surgery I had tremendous pain in my lower back. A nurse friend who also as RA said I should try it, I took 30mg the first night and rocketed out of bed the next morning; the second night/morning the same thing, no pain and the flexibility to jump right out of bed. The third night I was wondering if I was just having a good couple of mornings, so I skipped the dose; I woke up at 2am with excruciating pain and downed the cymbalta. The next morning around 9am, I launched out of bed forgetting all about any pain. Bottom line, for me it was a God send, like most meds; you can't expect everyone to react the same. It's not rocket science people, get a weeks worth of samples.”

9 / 10
Monismystique July 16, 2015

“I have only been on this med for two days, but OMG what a difference! I have been in pain mgmt for 25 years for interstitial cystitis and during this time I went from being an energetic, happy person to nothing more than a shell. As the pain and pain med amounts increased, the quality of my so called life decreased to the point that for the last year I do ABSOLUTELY NOTHING but sit on the couch and read. No cooking, no cleaning, no going out, nothing! But after only 2 days, I'm starting to feel like my old self again! Much more energy and have even taken less pain Meds! I haven't had any side effects. Can't wait to see how this goes! Sooooo grateful!”

9 / 10
Extreme nerve pain · Taken for 2 to 5 years April 20, 2018

“I had two major strokes 4 years ago that caused permanent central nervous system damage, severe depression and anxiety. I had RLS, "needles and pins" pain, sharp stabbing pains, shaking, quivering, lack of motor control, and more. My neurologist and surgeon suggested I take 30mgs of Cymbalta, (Duloxetine), once before bed for pain. Since I started it two years ago, I am now about 80% pain free. The spasms and intense nerve pain only come when I am very fatigued. The only side effect has been some hot flashes and insomnia but I take Melatonin to sleep. Originally my doctors suggested OxyContin but I'd heard it was addictive so I tried the Duloxetine for pain and it works.”

9 / 10
Ponchita · Taken for 1 to 6 months July 13, 2016

“I had such terrible pain and lost my ability to walk. My Doctor put me on cymbalta and within 48 hours my pain had decreased. I had to up my dose from 20 to 30 and everything is fine and I am walking and my back and pelvis pain had greatly decreased. Thank God for the drug cymbalta.”

9 / 10
Issieanne · Taken for less than 1 month June 17, 2014

“After Just having begun my regimen on Duloxetine (2 days now) I am very encouraged with the relief I am experiencing. I have fought the pain from Rheumatoid Arthritis since Age 6...I am now 69 In the interim I've since had aggressive Fibromyalgia / AND Aggressive debilitating BRAIN FOG WITH Memory Loss (Prior to this I've been thinking seriously about checking my brain for Alzheimers). Now I am encouraged with results so far......HAPPY DAY! May this keep on working in my case this time. Many many Thanks.”

Leonela · Taken for 1 to 6 months December 7, 2019

“I have been on Cymbalta 20mg for the last 3 months for my neck pain. I am developing a skin rash in my neck. It’s itching and red. Also, little blisters too. Also, my appetite has decreased to the point that I have lost 10 pounds. My pain still the same.”

1 / 10
Fiverlo May 30, 2017

“I was prescribed this medication for depression several years ago. I did not think it was helping me so I had my doctor take me off of it 8 months ago. I was determined to handle my depression without it as I just wasn't seeing a big difference. Whoa. Was I wrong. I finally went back on it three days ago, and I can tell you that everyone I knew with rheumatoid arthritis, or osteoarthritis (as I do), my depression only worsened once my pain level increased each day, until finally I tried it again. Everyone I know who has pain from arthritis who has tried to stop taking Cymbalta, has returned to it much, much sooner than I did. I am sorry I suffered as long as I did before trying it again. It is a life saver and had given me my life back.”

8 / 10
Jack Lg May 1, 2015

“cymbalta has enabled me to come off tramadol for back pain, I don't urinate frequently from anxiety, I sleep better and feel 20 years younger. I guess I was depressed and didn't know it. Best med I have ever taken.”

10 / 10
Pus August 21, 2017

“This is the worst drug ever put out. I'm 70 and it has ruined my life when weaned off it has nearly killed me. I have been over a year of withdrawal and still going. They should be stopped from selling this and tell everyone you know to never be put on this crap - it will ruin your life”

Anonymous · Taken for 2 to 5 years December 30, 2020

“Had very severe, burning nerve pain in lower back. Had 3 hip replacements. 2 back surgeries. Knee surgery, Bypass surgery. Broken leg & ankle with screws broken shoulder & broken pelvis with screws. Prostate removal. Use of Duloxetine now 2 years. Never used pain meds at any time. On morphine drip after a surgery. Still try to be very active. Just had severe fall 20’ plus. Fall has damaged a lot of body parts again! Have extreme night sweats from Duloxetine. But feel up with plenty of energy. Nerve pain had diminished 90 %. After fall some a lot that pain has returned. Still have all the desires of life. But not unbearable Burning Nerve pain as it was before Duloxetine. Am 75, am physically strong. Need to know can I stay on Duloxetine for MANY more years?”

10 / 10
mel May 6, 2013

“I have been seeing my doctor for the last 3 years starting from back pain and fibromyalgia. I tried so much medication including 6 epidural injection in my lumbar and sacroiliac joint, nothing seems to work. Finally I was referred to an internal doctor and after reviewing my case she asked me to try Cymbalta. I finally get relief from it, my life is back to normal and I'm very satisfied.”

8 / 10
SeeToSee · Taken for 1 to 6 months September 19, 2015

“The only reason it's not a 10 for me is side effects, which were very significant at first but have gotten well into a reasonable range. I researched heavily before starting, know it can be hell to discontinue, and if the relief hadn't been so immense within days from both pain and anxiety I probably would have stopped it--glad I didn't. Took about 5-6 weeks for depression to get under control, but I feel great now. No cognitive issues like Neurotin, pain meds, and Ativan, no sleepiness for me (sleeplessness was a bigger problem at first). I have osteoarthritis, fibromyalgia, lumbar disk pain, GAD, chronic depression issues.”

9 / 10
Tuna1 November 5, 2016

“I developed a chronic pain syndrome post chole 25 year ago. My pain waxed and wained. Pain medication did nothing. The only thing that helped a little was muscle relaxants. My doctor suggested cymbalta. The effect was immediate. I just thought I was having a good week. I took 30 mg daily (lowest dose). The pain never returned. I still have muscle stiffness but the pain associated with it is gone. I have an arthritic thumb from an injury that still causes me pain. So for arthritic pain it does not seem to help. All I can say is give it a try. The effects for me were immediate.”

8 / 10
Diveranda · Taken for 1 to 6 months October 16, 2016

“My personal advice to anyone thinking of starting Cymbalta, don't do it. I only wish someone told me before I took it. Granted, it did take the edge off of some of my pain short term. The side effects just aren't worth it. I was fortunate enough to only suffer mood swings, anger, brain zaps and so on for about a month because I wasn't on it that long. They don't tell you that once you start taking Cymbalta, it's near impossible for someone to safely come off on their own if they have been on it more than a couple of months. Just please do your research. Some people have had great success but others barely lived to tell their horror stories and others aren't here”

4 / 10
Nana · Taken for 2 to 5 years April 4, 2019

“Cymbalta was very helpful for my fibromyalgia pain. My pain was reduced by 80%. It was also very helpful in reducing my anxiety. There was one side effect I could not tolerate any longer after 3 years, PROFUSE head sweating. I cold be sitting in an air conditioned house and break out in a horrible sweat. Once I realized it was the Cymbalta I had my doctor wean me off. Please don't stop this medication cold turkey, that can be dangerous.”

8 / 10
anonymous4347 July 2, 2013

“I have been on Cymbalta 60mg for chronic abdominal pain for 3 years. It has been a life saver for me and dropped my narcotic use (hydrocodone) down to a 30 day prescription lasting me a year. I did notice earlier this year more pain and with that more of the narcotic need and depression. My Dr. raised me up to 90mg (one 60mg and a 30mg) and I haven't had need of the hydrocodone for 3 months. I'm very satisfied.”

10 / 10

This information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners.