Skip to main content

Dienogest / estradiol and Depression: What Users Say

Brand names: Natazia

Depression: mentioned by 8 users (10.8%)

Based on user experiences from 74 Dienogest / estradiol reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

bleeding 23.0%
cramps 18.9%
acne 17.6%
weight gain 13.5%
depression 10.8%
mood swings 9.5%
nausea 9.5%
sexual dysfunction 9.5%
spotting 9.5%
headaches 8.1%

Reviews for Dienogest / estradiol

Commonly mentioned side effects
  • Col...
  • November 8, 2018

For Birth Control "I began Natazia at 14. I'm 21, so I've been on it 7 years. I have severe endometriosis, which is why I began the pill to treat it and preserve fertility. I've had laparoscopy. Natazia made my periods very light and short or often disappear. Pre-BC, I had 12-day periods that were incredibly painful and heavy. Now, I rarely bleed more than a day or two, even if I take the placebo. HOWEVER, I believe Natazia has caused incredibly severe and chronic issues for me: appetite disorders, milia around my eyes, severe anxiety, crippling depression, insomnia, exhaustion/tiredness, constant bloating, 10 lbs weight gain, nausea, headaches, nonexistent libido, dull hair, and uneven skin. I am very healthy otherwise, as I am a college athlete and eat a plant-based diet. I really am considering stopping BC altogether, this is truly unbearable. I'd rather bleed for 12 days than feel this way."

3 / 10
Was this helpful?YesNo
35 Report
  • Gin...
  • Taken for 1 to 6 months
  • September 9, 2019

For Heavy Menstrual Bleeding "I am 47 years old and approximately a year ago, I started to have irregular, heavy periods, depression, and anxiety. After some tests, I agreed with my provider that I am in perimenopause and it is normal to have some changes in periods, mood, and you name it. I tried OTC medications and herbs with some temporary relief. Two months ago, everything got worse, so my provider prescribed Natazia, which is a lifesaver for me. No more irregular and heavy bleeding, my mood and libido returned to normal, less anxiety and depressed mood, and no weight gain. I am very happy with this pill. Unfortunately, the copayment is high. The insurance companies should adjust this, otherwise, women with similar problems will not be able to purchase the product and get better. What about equality, my friends?"

10 / 10
Was this helpful?YesNo
18 Report
  • itz...
  • Taken for 6 months to 1 year
  • December 7, 2019

For Birth Control "I've tried at least 5 different types of birth control, and none of them worked. I would gain lots of weight, they made me feel tired and sad. Natazia is a miracle!! I have PCOS and was bleeding for months straight-9 months straight to be exact. I was tired of it and was finally recommended Natazia. After 6 months on it, my period is finally down to 3 days a month!! My cramps have seemed to get worse, but it's better than bleeding constantly. Insurance gave me a hard time, but after fighting, it's free and I don't have to pay $300 a month. I wouldn't recommend any other birth control other than this one, with no symptoms and little bleeding, I couldn't be happier!"

9 / 10
Was this helpful?YesNo
15 Report
  • My ...
  • January 3, 2020

For Birth Control "Started taking Natazia about 3-4 months ago. At the beginning, I experienced some breakthrough bleeding. My period would sometimes last for longer than seven days (up to 2 weeks). In the 3rd month, I experienced debilitating anxiety and what I think is depression (never been depressed before). What's interesting is that these feelings seemingly came all at once and rather suddenly. I've always been anxious, but this particular pill has over-amplified my anxiety. I had trouble making simple decisions without worrying about and obsessing over the outcome. Traveling, which I do a lot of, became a serious issue, which was never an issue before I started. Pros: my periods are lighter, and acne has improved. Yet, the anxiety, depression, and even weight gain are not worth it to me. I'm glad that I detected these signs after only taking it for a few months. If I opted to stay on it for longer, dealing with the anxiety, depression, and weight gain would have been unbearable."

3 / 10
Was this helpful?YesNo
15 Report
  • Ann...
  • September 12, 2016

For Birth Control "Awful experience. Took Natazia for 5 days and became so depressed and anxious. I would start crying for no reason and have serious mood swings and feel very irritable/annoyed at everyone around me. My vision became very blurry and my eyes were drier than normal (I have contact lenses). I was nauseous most days and felt very bloated. My migraines came back full force. I do not recommend this pill at all."

1 / 10
Was this helpful?YesNo
24 Report

Are you taking this medicine?

Your review helps others make informed decisions.
Write a review
  • Agn...
  • Taken for 5 to 10 years
  • February 13, 2018

For Birth Control "I switched between 8 different BC pills for 3 years 8 years ago and have been on this one ever since I found it. My periods used to be never-ending. They would start heavy and last for weeks to months, with only a week or two as a break from the bleeding. My iron and potassium levels were out of control, and we were looking for a BC pill that would help control my body's apparent addiction. Natazia was it. I never once had any issue with it. No depression, anxiety, headaches, light-headedness, etc. My insurance, without warning, decided to not cover the $200-300 medication over the summer, and I had to petition them with several of my doctors to get them to continue to cover it for me. It turns out that most insurance companies looked through all the Natazia reviews and decided that the majority of people taking it feel that it doesn't help them. But I feel like if it doesn't help you, you are obviously going to come off it and try something new."

10 / 10
Was this helpful?YesNo
13 Report
  • Sum...
  • October 29, 2014

For Birth Control "I switched from Sprintec (due to breakthrough bleeding) and began Natazia. Instantly, my appetite increased, and I was moody. I decided to ride it out for three months... what a mistake! I became depressed and crazy. Just switched today and hoping this new pill goes better."

7 / 10
Was this helpful?YesNo
10 Report
  • Anonymous
  • April 24, 2012

For Birth Control "I have been on a lot of pills, and this one has to be the worst. I never had acne before, and as soon as I started this pill, my face has been broken out. I have gained weight. I am depressed all month and have horrible PMS. But I haven't gotten pregnant, and my period seems to be the same."

1 / 10
Was this helpful?YesNo
9 Report

Are you taking this medicine?

Your review helps others make informed decisions.
Write a review
Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.