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Dienogest / estradiol and Weight Gain: What Users Say

Brand names: Natazia

Weight gain: mentioned by 10 users (13.5%)

Based on user experiences from 74 Dienogest / estradiol reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

bleeding 23.0%
cramps 18.9%
acne 17.6%
weight gain 13.5%
depression 10.8%
mood swings 9.5%
nausea 9.5%
sexual dysfunction 9.5%
spotting 9.5%
headaches 8.1%

Reviews for Dienogest / estradiol

Commonly mentioned side effects
  • LBa...
  • Taken for 5 to 10 years
  • June 4, 2019

Dienogest / estradiol for Birth Control "I’ve been on this birth control for 6 years and am very happy. I had very painful periods that would cause me to vomit from pain before. Now I have absolutely no period on this pill and love it. I skip the placebo pills and haven’t had a period in years. I do not want to have children, so I’m not concerned with any infertility issues. I tried other pills that gave me mood swings, breakouts, and weight gain. This pill actually makes me feel normal - when I’m not on the pill, I feel like my appetite is crazy. This pill helps regulate my appetite, helped clear my skin, and I have no periods at all for years. I’m very happy about all of these effects, and I will continue to only use Natazia."

10 / 10
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35 Report
  • Col...
  • November 8, 2018

Dienogest / estradiol for Birth Control "I began Natazia at 14. I'm 21, so I've been on it 7 years. I have severe endometriosis, which is why I began the pill to treat it and preserve fertility. I've had laparoscopy. Natazia made my periods very light and short or often disappear. Pre-BC, I had 12-day periods that were incredibly painful and heavy. Now, I rarely bleed more than a day or two, even if I take the placebo. HOWEVER, I believe Natazia has caused incredibly severe and chronic issues for me: appetite disorders, milia around my eyes, severe anxiety, crippling depression, insomnia, exhaustion/tiredness, constant bloating, 10 lbs weight gain, nausea, headaches, nonexistent libido, dull hair, and uneven skin. I am very healthy otherwise, as I am a college athlete and eat a plant-based diet. I really am considering stopping BC altogether, this is truly unbearable. I'd rather bleed for 12 days than feel this way."

3 / 10
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35 Report
  • Gin...
  • Taken for 1 to 6 months
  • September 9, 2019

Dienogest / estradiol for Heavy Menstrual Bleeding "I am 47 years old and approximately a year ago, I started to have irregular, heavy periods, depression, and anxiety. After some tests, I agreed with my provider that I am in perimenopause and it is normal to have some changes in periods, mood, and you name it. I tried OTC medications and herbs with some temporary relief. Two months ago, everything got worse, so my provider prescribed Natazia, which is a lifesaver for me. No more irregular and heavy bleeding, my mood and libido returned to normal, less anxiety and depressed mood, and no weight gain. I am very happy with this pill. Unfortunately, the copayment is high. The insurance companies should adjust this, otherwise, women with similar problems will not be able to purchase the product and get better. What about equality, my friends?"

10 / 10
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18 Report

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  • itz...
  • Taken for 6 months to 1 year
  • December 7, 2019

Dienogest / estradiol for Birth Control "I've tried at least 5 different types of birth control, and none of them worked. I would gain lots of weight, they made me feel tired and sad. Natazia is a miracle!! I have PCOS and was bleeding for months straight-9 months straight to be exact. I was tired of it and was finally recommended Natazia. After 6 months on it, my period is finally down to 3 days a month!! My cramps have seemed to get worse, but it's better than bleeding constantly. Insurance gave me a hard time, but after fighting, it's free and I don't have to pay $300 a month. I wouldn't recommend any other birth control other than this one, with no symptoms and little bleeding, I couldn't be happier!"

9 / 10
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15 Report
  • Anonymous
  • July 28, 2013

Dienogest / estradiol for Birth Control "I have been on Natazia for almost 2 years. For about a year and a half, I haven't really had a period. Some months, it's absolutely nothing at all. Occasionally, I spot. Last year, I told the gyno, she said it's nothing to worry about. My skin doesn't break out on this pill. I was on Ortho Tri-Cyclen Lo, my skin was terrible. I have gained a lot of weight since being on this pill, but the clear skin and no period are kind of worth it. I used to get terrible cramps and bleed a lot. Hope this is helpful."

10 / 10
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27 Report

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  • My ...
  • January 3, 2020

Dienogest / estradiol for Birth Control "Started taking Natazia about 3-4 months ago. At the beginning, I experienced some breakthrough bleeding. My period would sometimes last for longer than seven days (up to 2 weeks). In the 3rd month, I experienced debilitating anxiety and what I think is depression (never been depressed before). What's interesting is that these feelings seemingly came all at once and rather suddenly. I've always been anxious, but this particular pill has over-amplified my anxiety. I had trouble making simple decisions without worrying about and obsessing over the outcome. Traveling, which I do a lot of, became a serious issue, which was never an issue before I started. Pros: my periods are lighter, and acne has improved. Yet, the anxiety, depression, and even weight gain are not worth it to me. I'm glad that I detected these signs after only taking it for a few months. If I opted to stay on it for longer, dealing with the anxiety, depression, and weight gain would have been unbearable."

3 / 10
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15 Report
  • Anonymous
  • April 24, 2012

Dienogest / estradiol for Birth Control "I have been on a lot of pills, and this one has to be the worst. I never had acne before, and as soon as I started this pill, my face has been broken out. I have gained weight. I am depressed all month and have horrible PMS. But I haven't gotten pregnant, and my period seems to be the same."

1 / 10
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9 Report
  • Kat...
  • Taken for 6 months to 1 year
  • April 26, 2022

For Heavy Menstrual Bleeding "Worked VERY well to decrease pain caused by endometriosis and a large cyst on my ovary. It did not shrink the cyst but kept it from growing. I had a partial hysterectomy, but the endometriosis kept on. Numerous side effects, but maybe worth it considering the effect on pelvic pain? (Haven't decided, am trying something different). Breast tenderness ALL the time, weight gain (20 lbs over a year), some acne, more facial hair (started waxing my upper lip), decreased libido. Will be trying a different class of progestin as I have more time to wait before my next surgery (thanks to COVID, grumble, grumble)."

7 / 10
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2 Report
  • Dan...
  • July 18, 2017

Dienogest / estradiol for Birth Control "Great birth control! I have been on 3 different ones until I did my own research and came across Natazia. I have been taking this for 2 months now and feel as though I'm not taking anything at all (no felt side effects). Periods are only about 2 to 3 days in length and very light. All my previous menstrual issues have subsided. Only issue is the 10 lb weight gain..."

8 / 10
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4 Report
  • bca...
  • August 5, 2021

Dienogest / estradiol for Birth Control "This birth control made me gain 15 lbs and made me super dry. It did make my period lighter."

7 / 10
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1 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.