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Dienogest / Estradiol Dosage

Medically reviewed by Drugs.com. Last updated on Jan 25, 2022.

Applies to the following strengths: multiphasic

Usual Adult Dose for Contraception

1 tablet orally at the same time every day

  • Tablets must be taken in the order directed on the blister pack.

Comments:
  • Efficacy in women with a body mass index over 30 kg/m2 has not been evaluated.
  • To start: Take the first pill on the first day of the menstrual cycle; non-hormonal back-up contraceptives should be used for the first 9 days.
  • Starting postpartum: Start no earlier than 4 weeks postpartum due to increased thromboembolism risk; if no period has occurred, rule out pregnancy; non-hormonal back-up contraceptives should be used for the first 9 days.
  • Switching from another combination hormonal method: Take the first pill on the first day of withdrawal bleeding; if no withdrawal bleeding occurred, rule out pregnancy.
  • Switching from vaginal ring or transdermal patch: Take the first pill on the day the ring/patch is removed; non-hormonal back-up contraceptives should be used for the first 9 days.
  • Switching from a progestin-only method: Take the first pill on the day the next progestin-only pill would have been taken, the day of removal of an implant, or the day the next injection would have occurred; non-hormonal back-up contraceptives should be used for the first 9 days.

Uses:
  • Pregnancy prevention
  • Treatment of heavy menstrual bleeding without organic pathology in women who choose oral contraceptives for contraception

Renal Dose Adjustments

Data not available

  • Dose adjustments are not expected to be required.

Liver Dose Adjustments

Contraindicated in liver disease or impairment if liver function values have not returned to normal

  • Steroid hormones may be poorly metabolized in patients with impaired liver function.
  • Acute or chronic liver function disturbances may require discontinuation of oral contraceptives until markers of liver function return to normal.

Dose Adjustments

Gastrointestinal disturbances:

  • Severe vomiting or diarrhea may cause incomplete absorption; additional contraceptive measures should be taken.
  • If vomiting or diarrhea occurs within 3 to 4 hours of taking a colored tablet, regard this as a missed tablet.

Missed tablets:
  • Missed ONE tablet, more than 12 hours late:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.