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Ivabradine

Generic Name: ivabradine ((eye-VAB-ra-deen))
Brand Name: Corlanor

Ivabradine is used for:

It is used in certain patients with heart failure to lower the chance of having to go to the hospital for worsening heart failure.

Ivabradine is a cyclic nucleotide-gated channel blocker. It works by helping to regulate heart rate.

Do NOT use ivabradine if:

  • you are allergic to any ingredient in ivabradine
  • you have low blood pressure or severe liver problems
  • you have heart failure that is severe or gets worse
  • you have a slow heart before treatment with ivabradine
  • you have certain types of irregular heartbeat (eg, heart block, sick sinus syndrome) and you do not have a working pacemaker
  • your heartbeat is totally controlled by a pacemaker
  • you are taking azole antifungals (eg, itraconazole), barbiturates (eg, phenobarbital), diltiazem, macrolide antibiotics (eg, clarithromycin), nefazodone, phenytoin, protease inhibitors (eg, nelfinavir), rifampin, St. John's wort, telithromycin, or verapamil

Contact your doctor or health care provider right away if any of these apply to you.

Before using ivabradine:

Some medical conditions may interact with ivabradine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of heart problems (eg, irregular heartbeat)
  • if you have a defibrillator or pacemaker

Some medical conditions may interact with ivabradine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • Amiodarone, beta-blockers (eg, propranolol), digoxin, diltiazem, or verapamil because the risk of slow or irregular heartbeat may be increased
  • Azole antifungals (eg, itraconazole), macrolide antibiotics (eg, clarithromycin, telithromycin), nefazodone, or protease inhibitors (eg, nelfinavir) because they may increase the risk of ivabradine's side effects
  • Barbiturates (eg, phenobarbital), phenytoin, rifampin, or St. John's wort because they may decrease ivabradine's effectiveness

This may not be a complete list of all interactions that may occur. Ask your health care provider if ivabradine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use ivabradine:

Use ivabradine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Ivabradine comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get ivabradine refilled.
  • Take ivabradine by mouth with meals.
  • Take as you have been told, even if you feel well.
  • To gain the most benefit, do not miss doses.
  • If you miss a dose of ivabradine, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use ivabradine.

Important safety information:

  • Tell your doctor or dentist that you take ivabradine before you receive any medical or dental care, emergency care, or surgery.
  • Vision changes may happen, including brightness caused by sudden changes in light. Use ivabradine with caution when driving or doing other tasks or actions that call for clear eyesight. This includes driving at night. Discuss any questions or concerns with your doctor.
  • Do not eat grapefruit or drink grapefruit juice while you use ivabradine.
  • Check blood pressure and heart rate as the doctor has told you.
  • You will need to have your heart checked before starting this drug and while taking it. This includes an electrocardiogram (ECG). Discuss any questions or concerns with your doctor.
  • If you may become pregnant, you must use an effective form of birth control while you take ivabradine. If you have questions about effective birth control, talk with your doctor.
  • PREGNANCY and BREAST-FEEDING: Ivabradine may cause harm to the fetus. Do not become pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. It is not known if this medicine is found in breast milk. Do not breast-feed while taking ivabradine.

Possible side effects of ivabradine:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if you have side effects that persist or become bothersome. Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain or pressure; dizziness or fainting; irregular heartbeat; severe or persistent headache; shortness of breath; slow heartbeat; tiredness or weakness; vision changes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of ivabradine:

Store ivabradine between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep ivabradine out of the reach of children and away from pets.

General information:

  • If you have any questions about ivabradine, please talk with your doctor, pharmacist, or other health care provider.
  • Ivabradine is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take ivabradine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about ivabradine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to ivabradine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using ivabradine.

Review Date: November 3, 2016

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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