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Generic Name: ivabradine (eye VAB ra deen)
Brand Names: Corlanor

What is Corlanor?

Corlanor (ivabradine) works by affecting your heart's electrical activity in order to slow the heart rate.

Corlanor is used in certain people with chronic heart failure, to help lower the risk of needing to be hospitalized when symptoms get worse.

Corlanor is not for use if you already have heart failure symptoms that recently got worse before starting this medicine.

Important information

You should not use Corlanor if you have severe liver disease, if you depend on a pacemaker to regulate your heart rate, or if you have a serious heart condition such as "sick sinus syndrome" or 3rd-degree "AV block" (unless you have a pacemaker).

You also should not use Corlanor if your heart failure symptoms recently got worse, if your resting heart rate is less than 60 bpm, or if your blood pressure is less than 90 over 50.

Avoid becoming pregnant while you are taking Corlanor. Use effective birth control and tell your doctor right away if you become pregnant.

Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact with ivabradine, and some drugs should not be used together.

Corlanor can cause serious heart rhythm problems. Call your doctor at once if you have chest tightness, racing or pounding heartbeats, very slow heartbeats, weakness, tiredness, severe dizziness, or shortness of breath that is worse than usual.

Before taking this medicine

You should not use Corlanor if you are allergic to ivabradine, or if you have:

  • a serious heart condition such as "sick sinus syndrome" or 3rd-degree "AV block" (unless you have a pacemaker);

  • heart failure symptoms that recently got worse;

  • severe liver disease;

  • a resting heart rate of less than 60 beats per minute;

  • blood pressure lower than 90 over 50; or

  • if you depend on a pacemaker to regulate your heart rate.

Some medicines can cause unwanted or dangerous effects when used with Corlanor. Your doctor may need to change your treatment plan if you use any of the following drugs:

  • an antibiotic or antifungal medicine;

  • an antidepressant;

  • heart or blood pressure medicine; or

  • antiviral medicine to treat hepatitis C or HIV/AIDS.

To make sure Corlanor is safe for you, tell your doctor if you have:

  • other heart problems not being treated with Corlanor;

  • liver disease;

  • high or low blood pressure;

  • if you have a pacemaker; or

  • if you take other heart medicine or blood pressure medication, such as amiodarone, digoxin, diltiazem, or verapamil.

Use effective birth control to prevent pregnancy while you are taking this medicine. Taking Corlanor during pregnancy could harm the unborn baby or lead to premature birth. Tell your doctor right away if you become pregnant while taking Corlanor.

It is not known whether ivabradine passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

How should I take Corlanor?

Take Corlanor exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Corlanor is usually taken 2 times per day with meals. Avoid eating grapefruit or drinking grapefruit juice with this medicine.

You may also need to take another medicine called a beta-blocker. Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice.

Corlanor can cause a temporary brightness in your vision, especially during the first 2 months of treatment. This can make you see halos around lights, see colors within lights, or see multiple images while looking at an object. You may also see kaleidoscope colors or flashes of movement in certain parts of your vision. Sudden bright light can make these vision changes more noticeable. These effects usually go away as you continue taking Corlanor or after you stop taking it.

While using Corlanor, you may need frequent medical tests. Your heart function may need to be checked using an electrocardiograph or ECG (sometimes called an EKG).

Store at room temperature away from moisture and heat.

Corlanor dosing information

Usual Adult Dose for Congestive Heart Failure:

Initial dose: 5 mg orally twice a day with meals
Maximum dose: 7.5 mg orally twice a day

-In patients with a history of conduction defects or in patients whom bradycardia could lead to hemodynamic compromise, start with 2.5 mg orally twice a day.
-Assess after 2 weeks and adjust dose to maintain tolerability and achieve resting heart rate between 50 and 60 beats per minute (bpm); if resting heart rate is greater than 60 bpm, increase by 2.5 mg twice daily to a maximum of 7.5 mg twice daily; if resting heart rate is less than 50 bpm or bradycardia signs and symptoms occur, decrease by 2.5 mg twice daily (discontinue if current dose is 2.5 mg orally twice a day).

Use: To reduce worsening heart failure hospitalization risk in patients with stable, symptomatic chronic heart failure and left ventricular ejection fraction (LVEF) at or below 35%, who are in sinus rhythm with resting heart rate at or above 70 bpm and are either unable to tolerate or have a contraindication to beta-blockers.

See also: Dosage Information (in more detail)

What happens if I miss a dose?

Skip the missed dose and take the medicine when it is time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Corlanor?

Corlanor may cause dizziness or vision changes, which could impair your thinking or reactions. Be careful if you drive (especially at night) or do anything that requires you to be alert and able to see clearly.

Avoid sudden changes in the intensity of light around you, such as going outside in sunlight after being in a dark place. Allow your eyes time to adjust slowly to the light.

Grapefruit and grapefruit juice may interact with ivabradine and lead to unwanted side effects. Avoid the use of grapefruit products while taking Corlanor.

Avoid taking an herbal supplement containing St. John's wort at the same time you are taking Corlanor.

Corlanor side effects

Get emergency medical help if you have signs of an allergic reaction to Corlanor: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • chest tightness, racing or pounding heartbeats, fluttering in your chest;

  • shortness of breath that is worse than usual;

  • a light-headed feeling, like you might pass out; or

  • very slow heartbeats with dizziness, tiredness, or a lack of energy.

Common Corlanor side effects may include:

  • slow heart rate;

  • high blood pressure (severe headache, blurred vision, pounding in your neck or ears); or

  • your eyes may be more sensitive to light.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Corlanor?

Corlanor can cause a serious heart rhythm problems, especially if you use certain medicines at the same time, such as antibiotics, antifungal medicine, antidepressants, anti-malaria medicine, asthma inhalers, antipsychotic medicine, cancer medicine, certain HIV/AIDS medicine, heart or blood pressure medicine, or medicine to prevent vomiting.

Many other drugs can interact with ivabradine, and some drugs should not be used together. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

  • Your pharmacist can provide more information about Corlanor.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Corlanor only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2018 Cerner Multum, Inc. Version: 2.01.

Date modified: September 05, 2017
Last reviewed: July 25, 2017