Generic name: IVABRADINE HYDROCHLORIDE 5mg
Dosage form: tablet, film coated
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The recommended starting dose of Corlanor is 5 mg twice daily with meals. Assess patient after two weeks and adjust dose to achieve a resting heart rate between 50 and 60 beats per minute (bpm) as shown in Table 1. Thereafter, adjust dose as needed based on resting heart rate and tolerability. The maximum dose is 7.5 mg twice daily.
In patients with a history of conduction defects, or other patients in whom bradycardia could lead to hemodynamic compromise, initiate therapy at 2.5 mg twice daily before increasing the dose based on heart rate [see Warnings and Precautions (5.3)].
|Heart Rate||Dose Adjustment|
|> 60 bpm||Increase dose by 2.5 mg (given twice daily) up to a maximum dose of 7.5 mg twice daily|
|50-60 bpm||Maintain dose|
|< 50 bpm or signs and symptoms of bradycardia||Decrease dose by 2.5 mg (given twice daily); if current dose is 2.5 mg twice daily, discontinue therapy*|
*[see Warnings and Precautions (5.3).]