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Ivabradine Side Effects

In Summary

Commonly reported side effects of ivabradine include: bradycardia. Other side effects include: atrial fibrillation. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to ivabradine: oral tablet

Along with its needed effects, ivabradine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking ivabradine:

More common
  • Blurred vision
  • chest pain or discomfort
  • dizziness
  • fainting
  • fast or irregular heartbeat
  • headache
  • lightheadedness, dizziness, or fainting
  • nervousness
  • pounding in the ears
  • shortness of breath
  • slow or irregular heartbeat
  • unusual tiredness
Incidence not known
  • Confusion
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • sweating

Some side effects of ivabradine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Seeing flashes of light
Incidence not known
  • Double vision
  • feeling of constant movement of self or surroundings
  • flushing or redness of the skin
  • hives or welts, itching, or skin rash
  • seeing double
  • sensation of spinning
  • trouble seeing
  • unusually warm skin

For Healthcare Professionals

Applies to ivabradine: oral tablet


The most common side effects were cardiac failure, phosphene-like events, and bradycardia.[Ref]


Very common (10% or more): Cardiac failure (21.7%), bradycardia (up to 10%)
Common (1% to 10%): Hypertension, blood pressure increased, atrial fibrillation, ventricular extrasystoles, atrioventricular block first degree, unstable angina, angina pectoris aggravated, myocardial ischemia, blood pressure inadequately controlled, sinus tachycardia, supraventricular extrasystoles, atrial flutter, ventricular tachycardia, bradycardia symptomatic, bradycardia asymptomatic, angina pectoris, acute myocardial infarction, myocardial infarction, hypotension, sudden cardiac death
Uncommon (0.1% to 1%): Palpitations, sinus arrhythmia, ECG prolonged QT interval
Very rare (less than 0.01%): Atrioventricular block second degree, atrioventricular block third degree, sick sinus syndrome
Postmarketing reports: Torsade de pointes, ventricular fibrillation[Ref]


Very common (10% or more): Phosphene-like events (14.5%)
Common (1% to 10%): Phosphenes, visual brightness, blurred vision
Uncommon (0.1% to 1%): Diplopia, visual impairment[Ref]

Phosphenes generally occur within the first 2 months of treatment and may occur repeatedly afterward. They were generally reported as mild to moderate in intensity and led to discontinuation in less than 1% of patients. Most cases resolved during or after treatment.[Ref]


Common (1% to 10%): Pneumonia, bronchitis acute, bronchitis, nasopharyngitis, upper respiratory tract infection, respiratory tract infection, influenza, cough, chronic obstructive pulmonary disease
Uncommon (0.1% to 1%): Dyspnea[Ref]


Common (1% to 10%): Diabetes mellitus inadequately controlled, diabetes mellitus, hypercholesterolemia, hypokalemia, hyperuricemia[Ref]

Nervous system

Common (1% to 10%): Headache, dizziness, ischemic stroke
Uncommon (0.1% to 1%): Syncope[Ref]


Common (1% to 10%): Sudden death, fall
Uncommon (0.1% to 1%): Vertigo, asthenia, fatigue
Rare (less than 0.1%): Malaise[Ref]


Common (1% to 10%): Diarrhea, gastritis
Uncommon (0.1% to 1%): Nausea, constipation, abdominal pain[Ref]


Common (1% to 10%): Blood creatinine increased, anemia
Uncommon (0.1% to 1%): Eosinophilia[Ref]


Common (1% to 10%): Renal failure[Ref]


Common (1% to 10%): Transaminases increased[Ref]


Uncommon (0.1% to 1%): Angioedema, rash
Rare (less than 0.1%): Erythema, pruritus, urticaria[Ref]


Uncommon (0.1% to 1%): Muscle cramps[Ref]


1. Cerner Multum, Inc. "Australian Product Information." O 0

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. "Product Information. Corlanor (ivabradine)." Amgen USA, Thousand Oaks, CA.

Some side effects of ivabradine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

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