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ivabradine (Oral route)


Commonly used brand name(s)

In the U.S.

  • Corlanor

Available Dosage Forms:

  • Tablet

Therapeutic Class: Cardiovascular Agent

Uses For ivabradine

Ivabradine is used to reduce the risk of hospitalization in patients with worsening heart failure.

ivabradine is available only with your doctor's prescription.

Before Using ivabradine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For ivabradine, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to ivabradine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Appropriate studies have not been performed on the relationship of age to the effects of ivabradine in the pediatric population. Safety and efficacy have not been established.


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of ivabradine in the elderly.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking ivabradine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using ivabradine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Amifampridine
  • Aprepitant
  • Atazanavir
  • Bepridil
  • Boceprevir
  • Cisapride
  • Clarithromycin
  • Cobicistat
  • Conivaptan
  • Delavirdine
  • Dronedarone
  • Fluconazole
  • Fosaprepitant
  • Idelalisib
  • Imatinib
  • Indinavir
  • Itraconazole
  • Josamycin
  • Ketoconazole
  • Lopinavir
  • Mesoridazine
  • Nefazodone
  • Nelfinavir
  • Pimozide
  • Piperaquine
  • Posaconazole
  • Ritonavir
  • Saquinavir
  • Sparfloxacin
  • Telaprevir
  • Telithromycin
  • Terfenadine
  • Thioridazine
  • Tipranavir
  • Voriconazole
  • Ziprasidone

Using ivabradine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Alfuzosin
  • Amiodarone
  • Amitriptyline
  • Anagrelide
  • Apomorphine
  • Aprobarbital
  • Aripiprazole
  • Armodafinil
  • Arsenic Trioxide
  • Asenapine
  • Astemizole
  • Azithromycin
  • Bedaquiline
  • Bosentan
  • Buserelin
  • Butabarbital
  • Butalbital
  • Carbamazepine
  • Ceritinib
  • Chloroquine
  • Chlorpromazine
  • Ciprofloxacin
  • Citalopram
  • Clomipramine
  • Clozapine
  • Crizotinib
  • Cyclobenzaprine
  • Dabrafenib
  • Darunavir
  • Dasatinib
  • Degarelix
  • Delamanid
  • Desipramine
  • Deslorelin
  • Dexamethasone
  • Diltiazem
  • Disopyramide
  • Dofetilide
  • Dolasetron
  • Domperidone
  • Donepezil
  • Doxepin
  • Droperidol
  • Ebastine
  • Efavirenz
  • Enzalutamide
  • Eribulin
  • Erythromycin
  • Escitalopram
  • Eslicarbazepine Acetate
  • Etravirine
  • Famotidine
  • Felbamate
  • Fingolimod
  • Flecainide
  • Fluoxetine
  • Formoterol
  • Foscarnet
  • Fosphenytoin
  • Galantamine
  • Gatifloxacin
  • Gemifloxacin
  • Gonadorelin
  • Goserelin
  • Granisetron
  • Halofantrine
  • Haloperidol
  • Histrelin
  • Hydroquinidine
  • Hydroxychloroquine
  • Ibutilide
  • Iloperidone
  • Imipramine
  • Lapatinib
  • Leuprolide
  • Levofloxacin
  • Lumefantrine
  • Mefloquine
  • Mephobarbital
  • Methadone
  • Methohexital
  • Metronidazole
  • Mifepristone
  • Mitotane
  • Mizolastine
  • Modafinil
  • Moxifloxacin
  • Nafarelin
  • Nafcillin
  • Nevirapine
  • Nilotinib
  • Norfloxacin
  • Octreotide
  • Olanzapine
  • Ondansetron
  • Oxcarbazepine
  • Paliperidone
  • Panobinostat
  • Paroxetine
  • Pasireotide
  • Pazopanib
  • Pentamidine
  • Pentobarbital
  • Perflutren Lipid Microsphere
  • Perphenazine
  • Phenobarbital
  • Phenytoin
  • Primidone
  • Probucol
  • Procainamide
  • Prochlorperazine
  • Promethazine
  • Propafenone
  • Protriptyline
  • Quetiapine
  • Quinidine
  • Quinine
  • Ranolazine
  • Rifabutin
  • Rifampin
  • Rifapentine
  • Rilpivirine
  • Risperidone
  • Secobarbital
  • Sertindole
  • Sevoflurane
  • Siltuximab
  • Sodium Phosphate
  • Sodium Phosphate, Dibasic
  • Sodium Phosphate, Monobasic
  • Solifenacin
  • Sorafenib
  • Sotalol
  • St John's Wort
  • Sunitinib
  • Tacrolimus
  • Tamoxifen
  • Telavancin
  • Tetrabenazine
  • Thiopental
  • Tizanidine
  • Tolterodine
  • Toremifene
  • Trazodone
  • Trimipramine
  • Triptorelin
  • Vandetanib
  • Vardenafil
  • Vemurafenib
  • Venlafaxine
  • Verapamil
  • Vilanterol
  • Vinflunine
  • Vorinostat

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Other Medical Problems

The presence of other medical problems may affect the use of ivabradine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Atrial fibrillation or
  • Bradycardia (slow heartbeat) or
  • Heart rhythm problems (eg, heart block, sinus arrest)—Use with caution. May make these conditions worse.
  • Heart failure, decompensated or
  • Heart rhythm problem (eg, AV block, sinoatrial block, sick sinus syndrome), without a pacemaker or
  • Hypotension (low blood pressure) or
  • Liver disease, severe or
  • Pacemaker dependence—Should not be used in patients with these conditions.

Proper Use of ivabradine

Use ivabradine exactly as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered.

ivabradine comes with a Medication Guide. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Take ivabradine with food.

Do not eat grapefruit or drink grapefruit juice while you are using ivabradine. Grapefruit and grapefruit juice may change the amount of ivabradine that is absorbed in the body.


The dose of ivabradine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of ivabradine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (tablets):
    • For heart failure:
      • Adults—At first, 5 milligrams (mg) two times a day with food. Your doctor may adjust your dose as needed. However, the dose is usually not more than 7.5 mg two times a day.
      • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of ivabradine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using ivabradine

It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to check for unwanted effects.

Using ivabradine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.

Do not use ivabradine if you are also using clarithromycin (Biaxin®), itraconazole (Sporanox®), ketoconazole (Nizoral®), nefazodone (Serzone®), nelfinavir (Viracept®), or telithromycin (Ketek®). Using these medicines together may cause serious unwanted effects.

ivabradine may increase your risk of atrial fibrillation. Check with your doctor right away if you have fast or irregular heartbeat, dizziness, fainting, or trouble breathing while using ivabradine.

ivabradine may cause temporary visual brightness, usually caused by sudden changes in light (luminous phenomena or phosphenes). Use caution when driving or using machines where sudden changes in light can happen, especially when driving at night.

Do not take other medicines unless thy have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal (eg, St. John's wort) or vitamin supplements.

ivabradine Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common
  • Blurred vision
  • chest pain or discomfort
  • dizziness
  • fainting
  • fast or irregular heartbeat
  • headache
  • lightheadedness, dizziness, or fainting
  • nervousness
  • pounding in the ears
  • shortness of breath
  • slow or irregular heartbeat
  • unusual tiredness
Incidence not known
  • Confusion
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • sweating

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Seeing flashes of light
Incidence not known
  • Double vision
  • feeling of constant movement of self or surroundings
  • flushing or redness of the skin
  • hives or welts, itching, or skin rash
  • seeing double
  • sensation of spinning
  • trouble seeing
  • unusually warm skin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

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