Avatrombopag

Pronunciation: A-va-TROM-boe-pag
Brand name: Doptelet
Dosage form: tablet (20mg)
Drug class: Platelet-stimulating agents

Medically reviewed by Melisa Puckey, BPharm. Last updated on Jun 9, 2025.

What is avatrombopag?

Avatrombopag is a prescription medicine used to treat low platelet levels (thrombocytopenia) in adults with chronic liver disease who are scheduled to undergo a dental or medical procedure. Avatrombopag is also used to treat low blood platelet counts in adults with chronic immune thrombocytopenia (ITP) when other treatments have not worked well enough.

Avatrombopag brand name is Doptelet.

A low platelet count increases your risk of excessive bleeding during certain medical procedures. Avatrombopag works to increase platelet production by your body to help prevent bleeding.

Avatrombopag maleate is not a cure for thrombocytopenia, and it will not make your platelet counts normal in adults with chronic liver disease or chronic immune thrombocytopenia.

Avatrombopag tablets are taken once daily.

How does avatrombopag work?

Platelet production in the body starts with hematopoietic stem cells (HSCs), which develop into megakaryocyte cells that make platelets.

Doptelet works by increasing the number of hematopoietic stem cells, which leads to the production of more megakaryocytes and, in turn, raises platelet levels.

Doptelet mechanism of action is as a thrombopoietin receptor agonist, one of the platelet-stimulating agents.

Avatrombopag side effects

Common avatrombopag side effects 

Common avatrombopag side effects may include:

• fever;
• easy bruising or bleeding (nosebleeds, bleeding gums), purple or red spots on your skin;
• feeling tired;
• headache, joint pain;
• cold symptoms such as runny or stuffy nose, sneezing, sore throat;
• nausea, stomach pain; or
• swelling in your hands or feet.

Serious avatrombopag side effects

Get emergency medical help if you have signs of an allergic reaction to avatrombopag, including hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

There is a risk you could develop a blood clot while using avatrombopag maleate. Call your doctor or get emergency medical help if you have:

• chest pain, shortness of breath;
• fast heartbeats;
• pain, swelling, or redness in one or both legs;
• stomach pain or tenderness;
• sudden fever or chills, yellowing of your skin or eyes; or
• bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds.

This is not a complete list of side effects, and others may occur. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Related/similar drugs

Warnings

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

You should not use avatrombopag maleate if you are allergic to it or any of the inactive ingredients.

To make sure this medicine is safe for you, tell your doctor if you have ever had:

• a blood clot; or
• a bleeding or blood clotting disorder other than thrombocytopenia.

Your doctor will measure your platelet levels with a blood test before you start taking this medicine.

This medicine may harm an unborn baby. Tell your doctor if you are pregnant, planning a pregnancy, or become pregnant.

You should not breast-feed while using avatrombopag maleate, and for at least 2 weeks after your last dose.

How should I take avatrombopag?

Take avatrombopag tablets once daily with food.

When given before a medical procedure in people with chronic liver disease, avatrombopag is usually taken once daily for 5 days, beginning 10 to 13 days before your procedure. Carefully follow your doctor's dosing instructions about the timing of this medicine and the procedure.

Your doctor will measure your platelet levels to determine how long to treat you with avatrombopag maleate. You may also need blood tests for a few weeks after your last dose.

Avatrombopag tablets for chronic immune thrombocytopenia are taken once a day, with the dose adjusted when required to maintain an acceptable platelet count

Take avatrombopag maleate exactly as it was prescribed. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Store at room temperature away from moisture and heat. Keep each tablet in the foil blister pack until you are ready to take a dose.

Avatrombopag dosing information

Chronic liver disease avatrombopag dose

Thrombocytopenia in patients with chronic liver disease who are scheduled to undergo a procedure.

• The avatrombopag dose is once daily for 5 consecutive days
• Begin dosing 10 to 13 days before the scheduled procedure.
• The procedure should be 5 to 8 days after the last dose of avatrombopag
• The daily dose is based on the patient’s platelet count before the scheduled procedure
• Platelet count less than 40 x 10⁹/L: 60 mg once a day
• Platelet count 40 to less than 50 x 10⁹/L: 40 mg once a day

Chronic Immune Thrombocytopenia avatrombopag dose

Avatrombopag dose for chronic ITP:

• Avatrombopag 20 mg orally once a day. 
• Adjust the dose or frequency of dosing to maintain a platelet count greater than or equal to 50 x10⁹/L. 
• Do not exceed 40 mg per day.

Avatrombopag dose modifications

Dose modifications are required with the use of concomitant moderate or strong dual inducers or inhibitors of CYP2C9 and CYP3A4 in patients with chronic immune thrombocytopenia.

Avatrombopag formulations

Avatrombopag 20mg tablets (Doptelet brand)

What happens if I miss a dose?

For chronic immune thrombocytopenia: Take the missed dose as soon as you remember it. Take your next dose at the regular time and stay on your once-daily schedule. Do not take two doses at one time.

Before a scheduled medical procedure: Call your doctor for instructions if you miss a dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What to avoid

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect avatrombopag?

Other drugs may interact with avatrombopag maleate, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
This medicine has interactions with:

• moderate or strong dual inhibitor of CYP2C9 and CYP3A
• moderate or strong dual inducer of CYP2C9 and CYP3A4

Not all possible drug interactions are listed here.

Avatrombopag Package Insert

HCPs and patients often use the Avatrombopag Package Insert (PI) for more detailed information about this medicine. The Avatrombopag Package Insert contains more comprehensive information on Indications and Usage, Dosage and Administration, Clinical Pharmacology, Clinical Studies, Drug Interaction, and more. Discuss any medical questions you have with your HCP (health care professional). This is not all the information you need to know about this medicine for safe and effective use, and it does not take the place of talking to your doctor about your treatment.

The Package Insert is sometimes called Avatrombopag Prescribing Information (PI) or FDA label.

Ingredients

Doptelet active ingredient: avatrombopag
Doptelet Inactive ingredients: lactose monohydrate, colloidal silicon dioxide, crospovidone, magnesium stearate, and microcrystalline cellulose.
Doptelet tablet coating film: polyvinyl alcohol, talc, polyethylene glycol, titanium dioxide, and ferric oxide yellow.

Avatrombopag manufacturer

Avatrombopag manufacturer AkaRx, Inc., Morrisville, North Carolina 27560

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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