Avatrombopag Dosage
Medically reviewed by Drugs.com. Last updated on Jun 25, 2024.
Applies to the following strengths: 20 mg
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Thrombocytopenia
Chronic Liver Disease:
Platelet count less than 40 x 10(9)/L: 60 mg orally once a day starting 10 to 13 days prior to the scheduled procedure
Platelet count 40 to less than 50 x 10(9)/L: 40 mg orally once a day starting 10 to 13 days prior to the scheduled procedure
Duration of therapy: 5 days
Comments:
- Patients should undergo their procedure 5 to 8 days after the last dose of this drug.
- Do not use this drug to normalize platelet counts.
Use: Treatment of thrombocytopenia in patients with chronic liver disease who are scheduled to undergo a procedure.
Chronic Immune Thrombocytopenia:
Initial dose: 20 mg orally once a day with food
Maximum dose: 40 mg/day
Comments:
- Use the lowest dose needed to achieve and maintain a platelet count greater than or equal to 50 x 10(9)/L as necessary to reduce the risk for bleeding.
- Do not use this drug to normalize platelet counts.
Use: Treatment of thrombocytopenia in patients with chronic immune thrombocytopenia who have had an insufficient response to a previous treatment.
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
This drug should not be administered to normalize platelet counts.
Dose Adjustments
Chronic Immune Thrombocytopenia:
Concomitant moderate or strong dual inhibitors of CYP450 2C9 and 3A4: Initial dose: 20 mg orally 3 times a week
Concomitant moderate or strong dual inducers of CYP450 2C9 and 3A4: Initial dose: 40 mg orally once a day
Dose adjustment based on platelet count:
- Platelet count less than 50 x 10(9)/L after at least 2 weeks of treatment with this drug: Increase one dose level and wait 2 weeks to assess the effects of this regimen and any subsequent dose adjustments.
- Platelet count between 200 and 400 x 10(9)/L: Decrease one dose level and wait 2 weeks to assess the effects of this regimen and any subsequent dose adjustments.
- Platelet count greater than 400 x 10(9)/L: Stop this drug and increase platelet monitoring to twice a week. When platelet count is less than 150 x 10(9)/L, decrease one dose level and reinitiate therapy.
- Platelet count less than 50 x 10(9)/L after 4 weeks at 40 mg once a day: Discontinue this drug.
- Platelet count greater than 400 x 10(9)/L after 2 weeks at 20 mg once a week: Discontinue this drug.
Dose levels for titration:
- Dose level 6: 40 mg once a day
- Dose level 5: 40 mg three times a week AND 20 mg on the four remaining days of each week
- Dose level 4: 20 mg once a day
- Dose level 3: 20 mg three times a week
- Dose level 2: 20 mg twice a week OR 40 mg once a week
- Dose level 1: 20 mg once a week
Precautions
CONTRAINDICATIONS: None
Safety and efficacy have not been established in patients younger than 18 years.
Consult WARNINGS section for additional precautions.
Dialysis
Data not available
Other Comments
Administration advice:
- Administer with food.
- In case of a missed dose, the next dose should be administered as soon as possible; do not administer two doses at one time to make up for a missed dose. The next regularly scheduled dose should be administered at the usual time the next day.
Monitoring:
- Hematologic: Platelet count (chronic liver disease: prior to starting this drug and on the day of a procedure; chronic immune thrombocytopenia: weekly until a stable platelet count greater than or equal to 50 x 10(9)/L has been achieved, monthly thereafter, and weekly for at least 4 weeks following discontinuation)
Patient advice:
- Advise women not to breastfeed during treatment with this drug and for at least 2 weeks after the final dose.
- Advise pregnant women of the potential risk to a fetus.
- Advise females of reproductive potential to inform their prescriber of a known or suspected pregnancy.
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