Avatrombopag Side Effects

Medically reviewed by Drugs.com. Last updated on Jun 28, 2024.

Applies to avatrombopag: oral tablet.

Precautions

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood tests will be needed while you are using this medicine.

Blood clotting problems may occur while you are using this medicine. Check with your doctor right away if you have pain, swelling, or tenderness in your leg, or pain in your chest.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Common side effects of avatrombopag

Some side effects of avatrombopag may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Serious side effects of avatrombopag

Along with its needed effects, avatrombopag may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking avatrombopag:

See also:

For healthcare professionals

Applies to avatrombopag: oral tablet.

General adverse events

In patients with chronic liver disease, the prevailing adverse effects (occurring in at least 3% of cases) included pyrexia, abdominal pain, nausea, headache, fatigue, and peripheral edema. For patients with chronic immune thrombocytopenia, the most frequently observed adverse reactions (10% or more) consisted of headache, fatigue, contusion, epistaxis, upper respiratory tract infection, arthralgia, gingival bleeding, petechiae, and nasopharyngitis.^[Ref]

Cardiovascular

• Very common (10% or more): Contusion (26%)
• Common (1% to 10%): Thromboembolic events, hypertension
• Uncommon (0.1% to 1%): Myocardial infarction, deep vein thrombosis, jugular vein thrombosis, vasoconstriction^[Ref]

Dermatologic

• Very common (10% or more): Petechiae (11%)
• Common (1% to 10%): Acne
• Uncommon (0.1% to 1%): Alopecia, dry skin, ecchymosis, hyperhidrosis, pigmentation disorder, skin hemorrhage, skin irritation
• Postmarketing reports: Pruritus, rash, erythema, pruritus generalized, rash macular^[Ref]

Gastrointestinal

• Very common (10% or more): Gingival bleeding (13%)
• Common (1% to 10%): Nausea, diarrhea, vomiting, abdominal pain upper, flatulence
• Uncommon (0.1% to 1%): Abdominal discomfort, abdominal distension, abdominal pain lower, anorectal varices, constipation, eructation, gastroesophageal reflux disease, glossodynia, hemorrhoids, paraesthesia oral, swollen tongue, tongue disorder^[Ref]

Hematologic

• Common (1% to 10%): Splenomegaly
• Uncommon (0.1% to 1%): Anemia, leukocytosis, portal vein thrombosis^[Ref]

Hepatic

• Uncommon (0.1% to 1%): Portal vein thrombosis, increased aspartate aminotransferase, increased hepatic enzyme^[Ref]

Immunologic

• Postmarketing reports: Hypersensitivity reactions, swelling face, swollen tongue^[Ref]

Metabolic

• Common (1% to 10%): Hyperlipidemia, decreased appetite, increased blood glucose, decreased blood glucose, increased blood triglycerides, increased blood lactate dehydrogenase, increased alanine aminotransferase, increased blood gastrin
• Uncommon (0.1% to 1%): Hyponatremia, dehydration, hypertriglyceridemia, increased appetite, iron deficiency^[Ref]

Musculoskeletal

• Very common (10% or more): Arthralgia (13%)
• Common (1% to 10%): Back pain, pain in extremity, musculoskeletal pain
• Uncommon (0.1% to 1%): Arthropathy, limb discomfort, muscle spasms, muscular weakness, musculoskeletal chest pain
• Frequency not reported: Myalgia^[Ref]

Nervous system

• Very common (10% or more): Headache (up to 31%)
• Common (1% to 10%): Dizziness, head discomfort, migraine, paraesthesia
• Uncommon (0.1% to 1%): Cerebrovascular accident, cognitive disorder, dysgeusia, hypoesthesia, sensory disturbance, transient ischemia attack^[Ref]

Ocular

• Uncommon (0.1% to 1%): Abnormal sensation in eye, eye irritation, eye pruritus, eye swelling, increased lacrimation, ocular discomfort, photophobia, retinal artery occlusion, vision blurred, visual impairment^[Ref]

Oncologic

• Uncommon (0.1% to 1%): Myelofibrosis^[Ref]

Other

• Very common (10% or more): Fatigue (up to 28%), pyrexia (up to 11%)
• Common (1% to 10%): Asthenia, edema peripheral
• Uncommon (0.1% to 1%): Furuncle, thrombophlebitis septic, ear pain, hyperacusis, menorrhagia, nipple pain, chest discomfort, hunger, pain, peripheral swelling^[Ref]

Psychiatric

• Uncommon (0.1% to 1%): Mood swings^[Ref]

Renal

• Uncommon (0.1% to 1%): Hematuria^[Ref]

Respiratory

• Very common (10% or more): Epistaxis (19%), upper respiratory tract infection (15%), nasopharyngitis (10%)
• Common (1% to 10%): Dyspnea
• Uncommon (0.1% to 1%): Hemoptysis, nasal congestion, pulmonary embolism
• Postmarketing reports: Choking sensation, pharyngeal edema^[Ref]

Frequently asked questions

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Further information

Avatrombopag side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer