Avatrombopag Side Effects
Medically reviewed by Drugs.com. Last updated on Aug 22, 2023.
Applies to avatrombopag: oral tablet.
Serious side effects of Avatrombopag
Along with its needed effects, avatrombopag may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking avatrombopag:
- Bleeding of the gums
- Bloating or swelling of the face, arms, hands, lower legs, or feet
- rapid weight gain
- tingling of the hands or feet
- unusual weight gain or loss
- decreased urine output
- fast or irregular heartbeat
- increased thirst
- loss of consciousness
- muscle pain or cramps
- pale skin
- swelling of the face, ankles, or hands
- troubled breathing with exertion
- unusual bleeding or bruising
- unusual tiredness or weakness
Incidence not known
- Difficulty breathing
- pain in the chest, groin, or legs, especially the calves
- severe, sudden headache
- slurred speech
- sudden loss of coordination
- sudden, severe weakness or numbness in the arm or leg
- vision changes
Other side effects of Avatrombopag
Some side effects of avatrombopag may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Body aches or pain
- difficulty in moving
- ear congestion
- joint pain
- loss of voice
- muscle stiffness
- sore throat
- stomach pain
- stuffy or runny nose
For Healthcare Professionals
Applies to avatrombopag: oral tablet.
In patients with chronic liver disease, the prevailing adverse effects (occurring in at least 3% of cases) included pyrexia, abdominal pain, nausea, headache, fatigue, and peripheral edema. For patients with chronic immune thrombocytopenia, the most frequently observed adverse reactions (10% or more) consisted of headache, fatigue, contusion, epistaxis, upper respiratory tract infection, arthralgia, gingival bleeding, petechiae, and nasopharyngitis.[Ref]
Very common (10% or more): Contusion (26%)
Common (1% to 10%): Thromboembolic events, hypertension
Very common (10% or more): Petechiae (11%)
Common (1% to 10%): Acne
Uncommon (0.1% to 1%): Alopecia, dry skin, ecchymosis, hyperhidrosis, pigmentation disorder, skin hemorrhage, skin irritation
Very common (10% or more): Gingival bleeding (13%)
Common (1% to 10%): Nausea, diarrhea, vomiting, abdominal pain upper, flatulence
Uncommon (0.1% to 1%): Abdominal discomfort, abdominal distension, abdominal pain lower, anorectal varices, constipation, eructation, gastroesophageal reflux disease, glossodynia, hemorrhoids, paraesthesia oral, swollen tongue, tongue disorder[Ref]
Common (1% to 10%): Splenomegaly
Uncommon (0.1% to 1%): Portal vein thrombosis, increased aspartate aminotransferase, increased hepatic enzyme[Ref]
Postmarketing reports: Hypersensitivity reactions, swelling face, swollen tongue[Ref]
Common (1% to 10%): Hyperlipidemia, decreased appetite, increased blood glucose, decreased blood glucose, increased blood triglycerides, increased blood lactate dehydrogenase, increased alanine aminotransferase, increased blood gastrin
Very common (10% or more): Arthralgia (13%)
Common (1% to 10%): Back pain, pain in extremity, musculoskeletal pain
Uncommon (0.1% to 1%): Arthropathy, limb discomfort, muscle spasms, muscular weakness, musculoskeletal chest pain
Frequency not reported: Myalgia[Ref]
Very common (10% or more): Headache (up to 31%)
Common (1% to 10%): Dizziness, head discomfort, migraine, paraesthesia
Uncommon (0.1% to 1%): Abnormal sensation in eye, eye irritation, eye pruritus, eye swelling, increased lacrimation, ocular discomfort, photophobia, retinal artery occlusion, vision blurred, visual impairment[Ref]
Uncommon (0.1% to 1%): Myelofibrosis[Ref]
Very common (10% or more): Fatigue (up to 28%), pyrexia (up to 11%)
Common (1% to 10%): Asthenia, edema peripheral
Uncommon (0.1% to 1%): Mood swings[Ref]
Very common (10% or more): Epistaxis (19%), upper respiratory tract infection (15%), nasopharyngitis (10%)
Common (1% to 10%): Dyspnea
Uncommon (0.1% to 1%): Hemoptysis, nasal congestion, pulmonary embolism
Postmarketing reports: Choking sensation, pharyngeal edema[Ref]
Frequently asked questions
- What is Doptelet used for and how does it work?
- Mulpleta vs Doptelet - What's the difference?
- How do you take Doptelet before a medical or dental procedure?
More about avatrombopag
- Check interactions
- Compare alternatives
- Reviews (5)
- Dosage information
- During pregnancy
- Drug class: platelet-stimulating agents
- En español
Related treatment guides
1. Product Information. Doptelet (avatrombopag). Dova Pharmaceuticals. 2018.
2. Product Information. Doptelet (avatrombopag). Swedish Orphan Biovitrum Pty Ltd. 2023.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.