Avatrombopag Side Effects
Medically reviewed by Drugs.com. Last updated on Feb 21, 2022.
For the Consumer
Applies to avatrombopag: oral tablet
Side effects requiring immediate medical attention
Along with its needed effects, avatrombopag may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking avatrombopag:
Less common
- Bleeding of the gums
- nosebleeds
Less common
- Bloating or swelling of the face, arms, hands, lower legs, or feet
- rapid weight gain
- tingling of the hands or feet
- unusual weight gain or loss
Rare
- Confusion
- decreased urine output
- dizziness
- fast or irregular heartbeat
- headache
- increased thirst
- loss of consciousness
- muscle pain or cramps
- nausea
- pale skin
- seizures
- swelling of the face, ankles, or hands
- troubled breathing with exertion
- unusual bleeding or bruising
- unusual tiredness or weakness
- vomiting
Incidence not known
- Difficulty breathing
- pain in the chest, groin, or legs, especially the calves
- severe, sudden headache
- slurred speech
- sudden loss of coordination
- sudden, severe weakness or numbness in the arm or leg
- vision changes
Side effects not requiring immediate medical attention
Some side effects of avatrombopag may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Body aches or pain
- bruise
- chills
- cough
- difficulty in moving
- ear congestion
- fever
- joint pain
- loss of voice
- muscle stiffness
- sneezing
- sore throat
- stomach pain
- stuffy or runny nose
For Healthcare Professionals
Applies to avatrombopag: oral tablet
General
The most common serious adverse reactions were headache and hyponatremia.[Ref]
Nervous system
Very common (10% or more): Headache (up to 31%)[Ref]
Other
Very common (10% or more): Fatigue (up to 28%), pyrexia (up to 11%)
Common (1% to 10%): Edema peripheral[Ref]
Cardiovascular
Very common (10% or more): Contusion (26%)
Common (1% to 10%): Thromboembolic events
Respiratory
Very common (10% or more): Epistaxis (19%), upper respiratory tract infection (15%), nasopharyngitis (10%)
Postmarketing reports: Choking sensation, pharyngeal edema
Musculoskeletal
Very common (10% or more): Arthralgia (13%)
Frequency not reported: Myalgia[Ref]
Gastrointestinal
Very common (10% or more): Gingival bleeding (13%)
Common (1% to 10%): Abdominal pain, nausea[Ref]
Dermatologic
Very common (10% or more): Petechiae (11%)
Postmarketing reports: Pruritus, rash, erythema, pruritus generalized, rash macular
Metabolic
Uncommon (0.1% to 1%): Hyponatremia[Ref]
Hematologic
Frequency not reported: Anemia
Immunologic
Postmarketing reports: Hypersensitivity reactions, swelling face, swollen tongue
Frequently asked questions
- What is Doptelet used for and how does it work?
- Mulpleta vs Doptelet - What's the difference?
- How do you take Doptelet before a medical or dental procedure?
More about avatrombopag
- Drug interactions
- Dosage information
- During pregnancy or Breastfeeding
- Reviews (3)
- En español
- Drug class: platelet-stimulating agents
Patient resources
- Other brands
- Doptelet
Professional resources
Related treatment guides
References
1. "Product Information. Doptelet (avatrombopag)." Dova Pharmaceuticals, Durham, NC.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.