Avatrombopag Side Effects

Medically reviewed by Drugs.com. Last updated on Aug 22, 2023.

Applies to avatrombopag: oral tablet.

Serious side effects of Avatrombopag

Along with its needed effects, avatrombopag may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking avatrombopag:

Less common

Bleeding of the gums
nosebleeds

Less common

Bloating or swelling of the face, arms, hands, lower legs, or feet
rapid weight gain
tingling of the hands or feet
unusual weight gain or loss

Rare

Confusion
decreased urine output
dizziness
fast or irregular heartbeat
headache
increased thirst
loss of consciousness
muscle pain or cramps
nausea
pale skin
seizures
swelling of the face, ankles, or hands
troubled breathing with exertion
unusual bleeding or bruising
unusual tiredness or weakness
vomiting

Incidence not known

Difficulty breathing
pain in the chest, groin, or legs, especially the calves
severe, sudden headache
slurred speech
sudden loss of coordination
sudden, severe weakness or numbness in the arm or leg
vision changes

Other side effects of Avatrombopag

Some side effects of avatrombopag may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Body aches or pain
bruise
chills
cough
difficulty in moving
ear congestion
fever
joint pain
loss of voice
muscle stiffness
sneezing
sore throat
stomach pain
stuffy or runny nose

For Healthcare Professionals

Applies to avatrombopag: oral tablet.

General

In patients with chronic liver disease, the prevailing adverse effects (occurring in at least 3% of cases) included pyrexia, abdominal pain, nausea, headache, fatigue, and peripheral edema. For patients with chronic immune thrombocytopenia, the most frequently observed adverse reactions (10% or more) consisted of headache, fatigue, contusion, epistaxis, upper respiratory tract infection, arthralgia, gingival bleeding, petechiae, and nasopharyngitis.^[Ref]

Cardiovascular

Very common (10% or more): Contusion (26%)

Common (1% to 10%): Thromboembolic events, hypertension

Uncommon (0.1% to 1%): Myocardial infarction, deep vein thrombosis, jugular vein thrombosis, vasoconstriction^[Ref]

Dermatologic

Very common (10% or more): Petechiae (11%)

Common (1% to 10%): Acne

Uncommon (0.1% to 1%): Alopecia, dry skin, ecchymosis, hyperhidrosis, pigmentation disorder, skin hemorrhage, skin irritation

Postmarketing reports: Pruritus, rash, erythema, pruritus generalized, rash macular^[Ref]

Gastrointestinal

Very common (10% or more): Gingival bleeding (13%)

Common (1% to 10%): Nausea, diarrhea, vomiting, abdominal pain upper, flatulence

Uncommon (0.1% to 1%): Abdominal discomfort, abdominal distension, abdominal pain lower, anorectal varices, constipation, eructation, gastroesophageal reflux disease, glossodynia, hemorrhoids, paraesthesia oral, swollen tongue, tongue disorder^[Ref]

Hematologic

Common (1% to 10%): Splenomegaly

Uncommon (0.1% to 1%): Anemia, leukocytosis, portal vein thrombosis^[Ref]

Hepatic

Uncommon (0.1% to 1%): Portal vein thrombosis, increased aspartate aminotransferase, increased hepatic enzyme^[Ref]

Immunologic

Postmarketing reports: Hypersensitivity reactions, swelling face, swollen tongue^[Ref]

Metabolic

Common (1% to 10%): Hyperlipidemia, decreased appetite, increased blood glucose, decreased blood glucose, increased blood triglycerides, increased blood lactate dehydrogenase, increased alanine aminotransferase, increased blood gastrin

Uncommon (0.1% to 1%): Hyponatremia, dehydration, hypertriglyceridemia, increased appetite, iron deficiency^[Ref]

Musculoskeletal

Very common (10% or more): Arthralgia (13%)

Common (1% to 10%): Back pain, pain in extremity, musculoskeletal pain

Uncommon (0.1% to 1%): Arthropathy, limb discomfort, muscle spasms, muscular weakness, musculoskeletal chest pain

Frequency not reported: Myalgia^[Ref]

Nervous system

Very common (10% or more): Headache (up to 31%)

Common (1% to 10%): Dizziness, head discomfort, migraine, paraesthesia

Uncommon (0.1% to 1%): Cerebrovascular accident, cognitive disorder, dysgeusia, hypoesthesia, sensory disturbance, transient ischemia attack^[Ref]

Ocular

Uncommon (0.1% to 1%): Abnormal sensation in eye, eye irritation, eye pruritus, eye swelling, increased lacrimation, ocular discomfort, photophobia, retinal artery occlusion, vision blurred, visual impairment^[Ref]

Oncologic

Uncommon (0.1% to 1%): Myelofibrosis^[Ref]

Other

Very common (10% or more): Fatigue (up to 28%), pyrexia (up to 11%)

Common (1% to 10%): Asthenia, edema peripheral

Uncommon (0.1% to 1%): Furuncle, thrombophlebitis septic, ear pain, hyperacusis, menorrhagia, nipple pain, chest discomfort, hunger, pain, peripheral swelling^[Ref]