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Avatrombopag Side Effects

Medically reviewed by Last updated on Aug 22, 2023.

Applies to avatrombopag: oral tablet.

Serious side effects of Avatrombopag

Along with its needed effects, avatrombopag may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking avatrombopag:

Less common

  • Bleeding of the gums
  • nosebleeds

Less common

  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • rapid weight gain
  • tingling of the hands or feet
  • unusual weight gain or loss


  • Confusion
  • decreased urine output
  • dizziness
  • fast or irregular heartbeat
  • headache
  • increased thirst
  • loss of consciousness
  • muscle pain or cramps
  • nausea
  • pale skin
  • seizures
  • swelling of the face, ankles, or hands
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting

Incidence not known

  • Difficulty breathing
  • pain in the chest, groin, or legs, especially the calves
  • severe, sudden headache
  • slurred speech
  • sudden loss of coordination
  • sudden, severe weakness or numbness in the arm or leg
  • vision changes

Other side effects of Avatrombopag

Some side effects of avatrombopag may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Body aches or pain
  • bruise
  • chills
  • cough
  • difficulty in moving
  • ear congestion
  • fever
  • joint pain
  • loss of voice
  • muscle stiffness
  • sneezing
  • sore throat
  • stomach pain
  • stuffy or runny nose

For Healthcare Professionals

Applies to avatrombopag: oral tablet.


In patients with chronic liver disease, the prevailing adverse effects (occurring in at least 3% of cases) included pyrexia, abdominal pain, nausea, headache, fatigue, and peripheral edema. For patients with chronic immune thrombocytopenia, the most frequently observed adverse reactions (10% or more) consisted of headache, fatigue, contusion, epistaxis, upper respiratory tract infection, arthralgia, gingival bleeding, petechiae, and nasopharyngitis.[Ref]


Very common (10% or more): Contusion (26%)

Common (1% to 10%): Thromboembolic events, hypertension

Uncommon (0.1% to 1%): Myocardial infarction, deep vein thrombosis, jugular vein thrombosis, vasoconstriction[Ref]


Very common (10% or more): Petechiae (11%)

Common (1% to 10%): Acne

Uncommon (0.1% to 1%): Alopecia, dry skin, ecchymosis, hyperhidrosis, pigmentation disorder, skin hemorrhage, skin irritation

Postmarketing reports: Pruritus, rash, erythema, pruritus generalized, rash macular[Ref]


Very common (10% or more): Gingival bleeding (13%)

Common (1% to 10%): Nausea, diarrhea, vomiting, abdominal pain upper, flatulence

Uncommon (0.1% to 1%): Abdominal discomfort, abdominal distension, abdominal pain lower, anorectal varices, constipation, eructation, gastroesophageal reflux disease, glossodynia, hemorrhoids, paraesthesia oral, swollen tongue, tongue disorder[Ref]


Common (1% to 10%): Splenomegaly

Uncommon (0.1% to 1%): Anemia, leukocytosis, portal vein thrombosis[Ref]


Uncommon (0.1% to 1%): Portal vein thrombosis, increased aspartate aminotransferase, increased hepatic enzyme[Ref]


Postmarketing reports: Hypersensitivity reactions, swelling face, swollen tongue[Ref]


Common (1% to 10%): Hyperlipidemia, decreased appetite, increased blood glucose, decreased blood glucose, increased blood triglycerides, increased blood lactate dehydrogenase, increased alanine aminotransferase, increased blood gastrin

Uncommon (0.1% to 1%): Hyponatremia, dehydration, hypertriglyceridemia, increased appetite, iron deficiency[Ref]


Very common (10% or more): Arthralgia (13%)

Common (1% to 10%): Back pain, pain in extremity, musculoskeletal pain

Uncommon (0.1% to 1%): Arthropathy, limb discomfort, muscle spasms, muscular weakness, musculoskeletal chest pain

Frequency not reported: Myalgia[Ref]

Nervous system

Very common (10% or more): Headache (up to 31%)

Common (1% to 10%): Dizziness, head discomfort, migraine, paraesthesia

Uncommon (0.1% to 1%): Cerebrovascular accident, cognitive disorder, dysgeusia, hypoesthesia, sensory disturbance, transient ischemia attack[Ref]


Uncommon (0.1% to 1%): Abnormal sensation in eye, eye irritation, eye pruritus, eye swelling, increased lacrimation, ocular discomfort, photophobia, retinal artery occlusion, vision blurred, visual impairment[Ref]


Uncommon (0.1% to 1%): Myelofibrosis[Ref]


Very common (10% or more): Fatigue (up to 28%), pyrexia (up to 11%)

Common (1% to 10%): Asthenia, edema peripheral

Uncommon (0.1% to 1%): Furuncle, thrombophlebitis septic, ear pain, hyperacusis, menorrhagia, nipple pain, chest discomfort, hunger, pain, peripheral swelling[Ref]


Uncommon (0.1% to 1%): Mood swings[Ref]


Uncommon (0.1% to 1%): Hematuria[Ref]


Very common (10% or more): Epistaxis (19%), upper respiratory tract infection (15%), nasopharyngitis (10%)

Common (1% to 10%): Dyspnea

Uncommon (0.1% to 1%): Hemoptysis, nasal congestion, pulmonary embolism

Postmarketing reports: Choking sensation, pharyngeal edema[Ref]

Frequently asked questions


1. Product Information. Doptelet (avatrombopag). Dova Pharmaceuticals. 2018.

2. Product Information. Doptelet (avatrombopag). Swedish Orphan Biovitrum Pty Ltd. 2023.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.