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Avatrombopag Side Effects

Medically reviewed by Last updated on Feb 21, 2022.

For the Consumer

Applies to avatrombopag: oral tablet

Side effects requiring immediate medical attention

Along with its needed effects, avatrombopag may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking avatrombopag:

Less common

Less common

  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • rapid weight gain
  • tingling of the hands or feet
  • unusual weight gain or loss


  • Confusion
  • decreased urine output
  • dizziness
  • fast or irregular heartbeat
  • headache
  • increased thirst
  • loss of consciousness
  • muscle pain or cramps
  • nausea
  • pale skin
  • seizures
  • swelling of the face, ankles, or hands
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting

Incidence not known

  • Difficulty breathing
  • pain in the chest, groin, or legs, especially the calves
  • severe, sudden headache
  • slurred speech
  • sudden loss of coordination
  • sudden, severe weakness or numbness in the arm or leg
  • vision changes

Side effects not requiring immediate medical attention

Some side effects of avatrombopag may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Body aches or pain
  • bruise
  • chills
  • cough
  • difficulty in moving
  • ear congestion
  • fever
  • joint pain
  • loss of voice
  • muscle stiffness
  • sneezing
  • sore throat
  • stomach pain
  • stuffy or runny nose

For Healthcare Professionals

Applies to avatrombopag: oral tablet


The most common serious adverse reactions were headache and hyponatremia.[Ref]

Nervous system

Very common (10% or more): Headache (up to 31%)[Ref]


Very common (10% or more): Fatigue (up to 28%), pyrexia (up to 11%)

Common (1% to 10%): Edema peripheral[Ref]


Very common (10% or more): Contusion (26%)

Common (1% to 10%): Thromboembolic events


Very common (10% or more): Epistaxis (19%), upper respiratory tract infection (15%), nasopharyngitis (10%)

Postmarketing reports: Choking sensation, pharyngeal edema


Very common (10% or more): Arthralgia (13%)

Frequency not reported: Myalgia[Ref]


Very common (10% or more): Gingival bleeding (13%)

Common (1% to 10%): Abdominal pain, nausea[Ref]


Very common (10% or more): Petechiae (11%)

Postmarketing reports: Pruritus, rash, erythema, pruritus generalized, rash macular


Uncommon (0.1% to 1%): Hyponatremia[Ref]


Frequency not reported: Anemia


Postmarketing reports: Hypersensitivity reactions, swelling face, swollen tongue

Frequently asked questions


1. "Product Information. Doptelet (avatrombopag)." Dova Pharmaceuticals, Durham, NC.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.