Pronunciation: dop-TEL-et
Generic name: avatrombopag
Dosage form: tablet (20 mg), oral granules (10 mg)
Drug class: Platelet-stimulating agents

Medically reviewed by Carmen Pope, BPharm. Last updated on July 30, 2025.

What is Doptelet?

Doptelet is used to treat thrombocytopenia (a lack of platelets in the blood) in adults with chronic liver disease who are scheduled to undergo a medical procedure. Doptelet is also used to treat low blood platelet counts in:

• adults with chronic immune thrombocytopenia (ITP) who have had an insufficient response to a previous treatment
• children 1 year and older with persistent or chronic ITP who have had an insufficient response to a previous treatment.

Doptelet (avatrombopag) is not a cure for thrombocytopenia, and it will not make your platelet counts normal in adults with chronic liver disease or chronic immune thrombocytopenia.

Doptelet is available as Doptelet tablets and Doptelet Sprinkles. The sprinkle form is a capsule that contains granules that are mixed with a soft food or liquid for dosing. These dosage forms are NOT interchangeable and cannot be directly substituted for each other at the same dose. Contact your child's pharmacist or healthcare provider if you do not receive the correct dosage form.

Doptelet (avatrombopag) gained FDA approval on May 21, 2018. There is no generic.

Side effects

The most common side effects of Doptelet when used in adults with chronic liver disease (CLD) are:

• fever
• headache
• stomach (abdominal) pain
• tiredness
• nausea
• swelling of hands or feet.

The most common side effects of Doptelet when used in adults with ITP are:

• headache
• joint pain
• tiredness
• bleeding gums
• bruising
• purple or red spots on your skin
• nosebleed
• runny nose
• upper respiratory infection

The most common side effects of Doptelet or Doptelet Sprinkle when used in children with ITP are:

• viral infection
• fever
• runny nose
• pain in the mouth or throat
• cough.

These are not all of the possible side effects of Doptelet Tablets or Sprinkles. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Serious side effects and warnings

Get emergency medical help if you have signs of an allergic reaction to Doptelet: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

You could develop a blood clot while using Doptelet. Call your doctor or get emergency medical help if you have:

• chest pain, shortness of breath;
• fast heartbeats;
• pain, swelling, or redness in one or both legs;
• stomach pain or tenderness;
• sudden fever or chills, yellowing of your skin or eyes; or
• bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds.

This is not a complete list of side effects, and others may occur. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Related/similar drugs

Before taking this medicine

You should not use Doptelet if you are allergic to avatrombopag.

To make sure this medicine is safe for you, tell your doctor if you have ever had

• a blood clot
• a bleeding or blood clotting disorder other than thrombocytopenia. Your doctor will measure your platelet levels with a blood test before you start taking this medicine

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant.

You should not breast-feed while using Doptelet, and for at least 2 weeks after your last dose.

How should I take Doptelet?

Follow all directions on your medicine label and package. Take Doptelet exactly as your healthcare provider tells you to take it. Your healthcare provider will tell you how much Doptelet to take and when to start taking it, and may change your dose of Doptelet depending on your blood platelet counts.

Doptelet Tablets

Doptelet tablets come in a blister package and are not the same dosage form as Doptelet Sprinkle, which comes in a bottle and cannot be directly substituted for each other.

• Contact you or your child’s pharmacist or healthcare provider if you did not receive the correct dosage form.

The dosage and how often you take Doptelet depend on the condition you are being treated for. 

• Take with food.

For CLD, Doptelet is usually taken once daily for 5 days, starting 10 to 13 days before the procedure. The procedure is usually scheduled for 5 to 8 days after the last dose. Carefully follow your doctor's dosing instructions about the timing of this medicine and the procedure.

• Your healthcare provider will check your platelet count before treatment and on the day of your scheduled procedure.
• If you are taking Doptelet before a scheduled medical procedure and you miss a dose, contact your healthcare provider for further dosing instructions.

For ITP, Doptelet is usually taken daily.

• Your healthcare provider will check your platelet count before, during, and for at least 4 weeks after stopping your treatment with Doptelet.
• Note: the dosage or frequency of dosing may be adjusted depending on your platelet count.

How should I give Doptelet Sprinkle?

Doptelet Sprinkle oral granules are not the same dosage form as Doptelet tablets that come in a blister card and cannot be directly substituted for each other. Contact your child’s pharmacist or healthcare provider if you did not receive the correct dosage form.

If your child is prescribed Doptelet Sprinkle: See the Instructions for Use on how to prepare and give a dose.

• Open the capsules and sprinkle the contents onto a small amount of a soft food or liquid. Mix or stir the granules into the soft food or liquid and take them right away.
• Do not swallow the capsules whole or the empty capsule shells.
• Do not chew or crush the oral granules.
• Give Doptelet Sprinkle exactly as your child’s healthcare provider tells you to give it.
• Your child’s healthcare provider will tell you how much Doptelet Sprinkle to give and when to start taking it.
• Your child’s healthcare provider may change the dose of Doptelet Sprinkle.
• Give your child Doptelet Sprinkle with food.
• If your child is taking Doptelet Sprinkle to treat low blood platelet counts due to persistent or chronic immune thrombocytopenia, your child’s healthcare provider will check your child’s platelet count before, during, and for at least 4 weeks after stopping treatment with Doptelet Sprinkle.

Dosing information

Dose of Doptelet for Chronic Liver Disease (Adults):

• Platelet count less than 40 x 10⁹/L: 60 mg orally once a day for 5 days, starting 10 to 13 days before the scheduled procedure
• Platelet count 40 to less than 50 x 10⁹/L: 40 mg orally once a day for 5 days starting 10 to 13 days before the scheduled procedure.

Patients should undergo their procedure 5 to 8 days after the last dose of this drug.

Dose of Doptelet for Chronic Immune Thrombocytopenia (Adults and Children 6 years and older): 

• 20 mg orally once a day. 
• Adjust the dose or frequency of dosing to maintain a platelet count greater than or equal to 50 x10⁹/L.
• Do not exceed 40 mg/day.

Dose of Doptelet for Chronic Immune Thrombocytopenia (Children aged 1 to 6 years): 

• 10 mg (1 Capsule) Doptelet Sprinkle once a day.
• Adjust the dose or frequency of dosing to maintain a platelet count greater than or equal to 50 x10⁹/L.
• Do not exceed 20 mg/day.

What happens if I miss a dose?

For chronic immune thrombocytopenia: Take the missed dose as soon as you remember it. Take your next dose at the regular time and stay on your once-daily schedule. Do not take two doses at one time.

Before a scheduled medical procedure: Call your doctor for instructions if you miss a dose.

What happens if I overdose?

If you take too much Doptelet or Doptelet Sprinkle, call your healthcare provider or Poison Help Line at 1-800-222-1222, or go to the nearest hospital emergency room right away.

What to avoid

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect Doptelet?

Other drugs may interact with avatrombopag, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

This medicine interacts with:

• moderate or strong dual inhibitors of CYP2C9 and CYP3A
• moderate or strong dual inducers of CYP2C9 and CYP3A4

Not all possible drug interactions are listed here.

Package Insert 

Review the Doptelet Package Insert for more detailed information about this medicine. Discuss any medical questions you have with your doctor or other health care provider. This is not all the information you need to know about this medicine for safe and effective use, and it does not take the place of talking to your doctor about your treatment.

The Package Insert is sometimes called Prescribing Information (PI) or the FDA label.

Storage

Store at room temperature away from moisture and heat. Keep each tablet in the foil blister pack and each sprinkle capsule in its original packaging until you are ready to take a dose.

Ingredients

Active ingredient: avatrombopag

Inactive ingredients in Doptelet tablets: colloidal silicon dioxide, crospovidone, lactose monohydrate, magnesium
stearate, and microcrystalline cellulose. Tablet coating film: ferric oxide yellow, polyethylene glycol, polyvinyl alcohol, talc, and titanium dioxide.

Inactive ingredients in Doptelet Sprinkle: crospovidone Type A, magnesium stearate, mannitol, microcrystalline cellulose, and sodium lauryl sulfate. Capsule shells: Hypromellose. 

Company

Doptelet tablets and sprinkles are manufactured for AkaRx, Inc., Morrisville, North Carolina 27560.

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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