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Doptelet

Generic Name: avatrombopag (A va TROM boe pag)
Brand Names: Doptelet

Medically reviewed on Nov 11, 2018

What is Doptelet?

Doptelet (avatrombopag) is used to treat thrombocytopenia (a lack of platelets in the blood) in adults with chronic liver disease who are scheduled to undergo a medical procedure.

Doptelet is not a cure for thrombocytopenia and it will not make your platelet counts normal in adults with chronic liver disease.

A low platelet count increases the risk of exces much bleeding during certain medical procedures. Doptelet increases the production of platelets by your body to help prevent too much bleeding.

Important Information

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

You should not use Doptelet if you are allergic to avatrombopag.

To make sure this medicine is safe for you, tell your doctor if you have ever had:

  • a blood clot; or

  • a bleeding or blood clotting disorder other than thrombocytopenia.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant.

You should not breast-feed while using Doptelet, and for at least 2 weeks after your last dose.

How should I take Doptelet?

Take Doptelet exactly as it was prescribed. Follow all directions on your prescription label and read all medication guides or instruction sheets.

Doptelet is usually taken once daily for 5 days, beginning 10 to 13 days before your procedure.

Take this medicine with food.

Carefully follow your doctor's dosing instructions about the timing of this medication and your procedure.

Store at room temperature away from moisture and heat. Keep each tablet in the foil blister pack until you are ready to take a dose.

Doptelet dosing information

Usual Adult Dose for Thrombocytopenia:

Platelet count less than 40 x 10(9)/L: 60 mg orally once a day starting 10 to 13 days prior to the scheduled procedure
Platelet count 40 to less than 50 x 10(9)/L: 40 mg orally once a day starting 10 to 13 days prior to the scheduled procedure

Duration of therapy: 5 days

Comments: Patients should undergo their procedure 5 to 8 days after the last dose of this drug.

Use: Treatment of thrombocytopenia in patients with chronic liver disease who are scheduled to undergo a procedure.

What happens if I miss a dose?

Take the missed dose as soon as you remember it. Take your next dose at the regular time and stay on your once-daily schedule. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Doptelet?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Doptelet side effects

Get emergency medical help if you have signs of an allergic reaction to Doptelet: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

You could develop a blood clot while using avatrombopag. Call your doctor or get emergency medical help if you have:

  • pain, swelling, or redness in one or both legs;

  • chest pain, shortness of breath;

  • fast heartbeats; or

  • stomach pain or tenderness.

Common Doptelet side effects may include:

  • fever;

  • feeling tired;

  • headache;

  • nausea, stomach pain; or

  • swelling in your hands or feet.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Doptelet?

Other drugs may interact with avatrombopag, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Doptelet only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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