Pronunciation: dop-TEL-et
Generic name: avatrombopag [ A-va-TROM-boe-pag ]
Dosage form: tablet (20 mg)
Drug class: Platelet-stimulating agents

Medically reviewed by Melisa Puckey, BPharm. Last updated on Jun 29, 2025.

What is Doptelet?

Doptelet is used to treat thrombocytopenia (a lack of platelets in the blood) in adults with chronic liver disease who are scheduled to undergo a medical procedure.

A low platelet count increases the risk of excessive bleeding during certain medical procedures. Avatrombopag increases the production of platelets by your body to help prevent too much bleeding.

Doptelet is also used to treat low blood platelet counts in adults with chronic immune thrombocytopenia (ITP) when other treatments have not worked well enough.

Doptelet is also used to treat chronic immune thrombocytopenia when other treatments have failed.

Doptelet (avatrombopag) is not a cure for thrombocytopenia and it will not make your platelet counts normal in adults with chronic liver disease or chronic immune thrombocytopenia.

Doptelet side effects

Common Doptelet side effects may include:

• fever;
• easy bruising or bleeding (nosebleeds, bleeding gums), purple or red spots on your skin;
• feeling tired;
• headache, joint pain;
• cold symptoms such as runny or stuffy nose, sneezing, sore throat;
• nausea, stomach pain; or
• swelling in your hands or feet.

Serious side effects 

Get emergency medical help if you have signs of an allergic reaction to Doptelet: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

You could develop a blood clot while using avatrombopag. Call your doctor or get emergency medical help if you have:

• chest pain, shortness of breath;
• fast heartbeats;
• pain, swelling, or redness in one or both legs;
• stomach pain or tenderness;
• sudden fever or chills, yellowing of your skin or eyes; or
• bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds.

This is not a complete list of side effects, and others may occur. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Related/similar drugs

Warnings

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

You should not use Doptelet if you are allergic to avatrombopag.

To make sure this medicine is safe for you, tell your doctor if you have ever had

• a blood clot; or
• a bleeding or blood clotting disorder other than thrombocytopenia.Your doctor will measure your platelet levels with a blood test before you start taking this medicine.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant.

You should not breast-feed while using Doptelet, and for at least 2 weeks after your last dose.

How should I take Doptelet?

Doptelet tablets are usually taken once daily with food. For chronic immune thrombocytopenia, it is taken every day.

When given before a medical procedure in people with chronic liver disease, Doptelet is usually taken once daily for 5 days, beginning 10 to 13 days before your procedure and having the procedure 5 to 8 days after the last dose. Carefully follow your doctor's dosing instructions about the timing of this medicine and the procedure.

Your doctor will measure your platelet levels weekly to determine how long to treat you with avatrombopag. You may also need blood tests for a few weeks after your last dose.

Take Doptelet exactly as it was prescribed. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Store at room temperature away from moisture and heat. Keep each tablet in the foil blister pack until you are ready to take a dose.

Doptelet dosing information

Doptelet dose for chronic liver disease when scheduled to undergo a procedure (adults):

• Platelet count less than 40 x 109/L: 60 mg orally once a day starting 10 to 13 days prior to the scheduled procedure
• Platelet count 40 to less than 50 x 109/L: 40 mg orally once a day starting 10 to 13 days prior to the scheduled procedure.
• Duration of therapy 5 days
• Patients should undergo their procedure 5 to 8 days after the last dose of this drug.

Doptelet dose for chronic immune thrombocytopenia (adults): 

• 20 mg orally once a day. 
• Adjust the dose or frequency of dosing to maintain a platelet count greater than or equal to 50 x109/L.
• Do not exceed 40 mg per day.

What happens if I miss a dose?

For chronic immune thrombocytopenia: Take the missed dose as soon as you remember it. Take your next dose at the regular time and stay on your once-daily schedule. Do not take two doses at one time.

Before a scheduled medical procedure: Call your doctor for instructions if you miss a dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What to avoid

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect Doptelet?

Other drugs may interact with avatrombopag, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

This medicine has interactions with:

• moderate or strong dual inhibitor of CYP2C9 and CYP3A
• moderate or strong dual inducer of CYP2C9 and CYP3A4

Not all possible drug interactions are listed here.

Doptelet Package Insert 

Review the Doptelet Package Insert for more detailed information about this medicine. Discuss any medical questions you have with your doctor or other health care provider. This is not all the information you need to know about this medicine for safe and effective use, and it does not take the place of talking to your doctor about your treatment.

The Package Insert is sometimes called Prescribing Information (PI) or the FDA label.

Ingredients

Active ingredient: avatrombopag
Inactive ingredients: lactose monohydrate, colloidal silicon dioxide, crospovidone, magnesium stearate and microcrystalline cellulose.
Tablet coating film: polyvinyl alcohol, talc, polyethylene glycol, titanium dioxide, and ferric oxide yellow.

Company

Manufactured for AkaRx, Inc., Morrisville, North Carolina 27560

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Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Doptelet only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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