What is Promacta?
Promacta (eltrombopag) is a man-made form of a protein that increases production of platelets (blood-clotting cells) in your body. Eltrombopag can lower the risk of bleeding by increasing platelets in your blood.
Promacta is used to prevent bleeding episodes in adults and children age 1 year and older, who have chronic immune thrombocytopenic purpura (ITP). ITP is a bleeding condition caused by a lack of platelets in the blood. This medicine is not a cure for ITP and it will not make your platelet counts normal if you have this condition.
Promacta is also used to prevent bleeding in adults with chronic hepatitis C who are treated with an interferon (such as Intron A, Infergen, Pegasys, PegIntron, Rebetron, Redipen, or Sylatron).
Promacta is also used together with other medications to treat severe aplastic anemia in adults and children who are at least 2 years old.
Promacta is sometimes given after other treatments have failed.
Promacta is not for use in treating myelodysplastic syndrome (also called "preleukemia").
Before you take Promacta tell your doctor if you have kidney disease, blood cancer, a bone marrow disorder, high platelet levels, liver problems (if you are not being treated for hepatitis C), a history of cataracts or blood clot, if your spleen has been removed, or if you are of East Asian descent. Also tell your doctor about all other medications you use.
Take Promacta on an empty stomach, at least 1 hour before or 2 hours after a meal. Do not take this medication with milk. Avoid all dairy products or products that contain calcium (including fortified fruit juice) for at least 4 hours before or after you take Promacta.
If you have chronic hepatitis C, taking Promacta with ribavirin and interferon treatment can increase your risk of liver problems. Call your doctor at once if you have signs of liver problems: nausea, upper stomach pain, confusion, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
After you stop taking this medicine, your risk of bleeding may be even higher than it was before you started treatment. Be extra careful to avoid cuts or injury for at least 4 weeks after you stop taking this medicine. Your blood will need to be tested weekly during this time.
Call your doctor at once if you have signs of liver problems: nausea, upper stomach pain, confusion, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Before taking this medicine
To make sure Promacta is safe for you, tell your doctor if you have ever had:
a blood clot;
liver disease (unless you are being treated for hepatitis C);
surgery to remove your spleen; or
if you are of East Asian descent (Chinese, Japanese, Taiwanese, or Korean).
Eltrombopag may harm an unborn baby. Use effective birth control to prevent pregnancy while taking this medicine, and for at least 7 days after your last dose. Tell your doctor if you become pregnant.
You should not breastfeed while using this medicine.
How should I take Promacta?
Take Promacta exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.
You may take Promacta in any of the following ways:
on an empty stomach, at least 1 hour before or 2 hours after eating;
with a meal containing fewer than 50 milligrams of calcium; or
at least 2 hours before or 4 hours after eating foods high in calcium (dairy products, calcium-fortified juices, certain fruits and vegetables).
Swallow the tablet whole and do not crush, chew, or break it.
Mix the oral suspension powder only with water. Use a new dosing syringe each time you mix the medicine, to measure the water and to give the correct dose.
You may need frequent medical tests to check your bone marrow cells or liver function. Your eyes may also need to be checked for signs of cataracts.
Eltrombopag doses are based on weight in children younger than 6 years old. Your child's dose needs may change if the child gains or loses weight.
Promacta is usually taken for 6 months. It may take up to 4 weeks before the medicine prevents major bleeding episodes. Keep taking as directed and tell your doctor if you have any bruising or bleeding episodes after 4 weeks of taking Promacta.
If you take Promacta with medication to treat chronic hepatitis C, tell your doctor if you stop using any of your hepatitis medications.
Store at room temperature away from moisture and heat. Keep the tablets in their original container. After mixing the oral suspension, store the liquid at room temperature and use it within 30 minutes.
After you stop taking Promacta, your risk of bleeding or bruising may be even higher than it was before you started treatment. Be extra careful to avoid cuts or injury for at least 4 weeks after you stop taking this medicine. Your blood will need to be tested weekly during this time.
What happens if I miss a dose?
Skip the missed dose and take your next dose at the regular time. Do not take two doses in one day.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Taking too much Promacta may cause a life-threatening blood clot.
What to avoid
Ask your doctor before using an antacid, and use only the type your doctor recommends. Some antacids can make it harder for your body to absorb eltrombopag and should not be taken at the same time.
Avoid foods high in calcium (including calcium-fortified fruit juice and certain fruits or vegetables) for at least 4 hours before or 2 hours after you take Promacta.
Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.
Promacta side effects
Get emergency medical help if you have signs of an allergic reaction to Promacta: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
You could develop a blood clot if your platelet count gets too high while you are using Promacta. Call your doctor or get emergency medical help if you have:
signs of a blood clot in the lung - chest pain, sudden cough, wheezing, rapid breathing, coughing up blood; or
signs of a blood clot in your leg - pain, swelling, warmth, or redness in one or both legs.
Call your doctor at once if you have:
any bruising or bleeding episodes during or after treatment with Promacta;
vision changes, tunnel vision, eye pain, or seeing halos around lights;
pain or burning when you urinate;
low red blood cells (anemia) - pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet; or
liver problems - confusion, tiredness, stomach pain (upper right side), stomach swelling, dark urine, jaundice (yellowing of the skin or eyes).
Common Promacta side effects may include:
abnormal bone marrow or liver function tests.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect Promacta?
Some medicines can make eltrombopag much less effective when taken at the same time. If you take any of the following medicines, take your Promacta dose 2 hours before or 4 hours after you take the other medicine:
an antacid; or
Tell your doctor about all your other medicines, especially:
This list is not complete. Other drugs may interact with eltrombopag, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Following treatment with Promacta (Revolade, eltrombopag olamine) a maximum response (increase in platelet counts) was reached at approximately two weeks, according to the results of clinical trials.
Promacta is a thrombopoietin receptor agonist that is used to increase low blood platelet counts (thrombocytopenia) in certain people with chronic immune thrombocytopenia (ITP) and severe aplastic anemia. Continue reading
Promacta film-coated tablets should be swallowed whole according to the prescribing information. They should not be split, chewed or crushed and mixed with foods or liquids. Continue reading
More about Promacta (eltrombopag)
- Side Effects
- During Pregnancy
- Dosage Information
- Patient Tips
- Drug Images
- Drug Interactions
- Compare Alternatives
- Pricing & Coupons
- En Español
- 8 Reviews
- Drug class: platelet-stimulating agents
- FDA Approval History
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Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Promacta only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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