Vivlodex Side Effects
Generic name: meloxicam
Medically reviewed by Drugs.com. Last updated on Jul 16, 2024.
Note: This document provides detailed information about Vivlodex Side Effects associated with meloxicam. Some dosage forms listed on this page may not apply specifically to the brand name Vivlodex.
Applies to meloxicam: oral capsule, oral suspension, oral tablet, oral tablet disintegrating.
Other dosage forms:
Important warnings
This medicine can cause some serious health issues
Oral route (capsule; suspension; tablet; tablet, disintegrating)
NSAIDs cause an increased risk of serious cardiovascular thrombotic events, including myocardial infarction and stroke, which can be fatal.
This risk may occur early in treatment and may increase with duration of use.
Meloxicam is contraindicated in the setting of CABG surgery.
NSAIDs also cause an increased risk of serious gastrointestinal (GI) adverse events, including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal.
These events can occur at any time during use and without warning symptoms.
Elderly patients and those with a prior history of peptic ulcer disease or GI bleeding are at a greater risk for serious GI events.
Precautions
It is very important that your doctor check your or your child's progress at regular visits to make sure that this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.
This medicine may increase your risk of having a heart attack, blood clot, or stroke. This is more likely to occur in people who already have heart and blood vessel disease and who are using this medicine for a long time. Check with your doctor right away if you are having chest pain or discomfort, nausea or vomiting, pain or discomfort in the arms, jaw, back, or neck, trouble breathing, slurred speech, or weakness.
Meloxicam may cause bleeding in your stomach or bowels. This problem can happen without warning signs. This is more likely to occur if you or your child have had a stomach ulcer in the past, if you smoke or drink alcohol regularly, if you are over 60 years of age, are in poor health, or are using certain other medicines (eg, steroids, blood thinner).
Liver problems may occur while you are using this medicine. Check with your doctor right away if you or your child are having more than one of these symptoms: abdominal or stomach pain or tenderness, clay-colored stools, dark urine, decreased appetite, fever, headache, itching, loss of appetite, nausea and vomiting, skin rash, swelling of the feet or lower legs, unusual tiredness or weakness, or yellow eyes or skin.
Check with your doctor right away if you have bloody urine, a decrease in frequency or amount of urine, an increase in blood pressure, increased thirst, loss of appetite, lower back or side pain, nausea, swelling of the face, fingers, or lower legs, troubled breathing, unusual tiredness or weakness, vomiting, or weight gain. These could be symptoms of a serious kidney problem.
Serious side effects can occur during treatment with this medicine and can occur without warning. However, possible warning signs often occur, including severe stomach pain, black tarry stools, vomiting of blood or material that looks like coffee grounds, skin rash, swelling of the face, fingers, feet, or lower legs. Also, signs of serious heart problems could occur such as chest pain, tightness in the chest, fast or irregular heartbeat, or unusual flushing or warmth of the skin. Check with your doctor immediately if you or your child notice any of these warning signs.
Meloxicam may cause a serious type of allergic reaction called anaphylaxis. Although this is rare, it may occur often in patients who are allergic to aspirin or other nonsteroidal anti-inflammatory drugs. Anaphylaxis can be life-threatening and requires immediate medical attention. The most serious signs of this reaction are very fast or irregular breathing, gasping for breath, or fainting. Other signs may include changes in skin color of the face, very fast but irregular heartbeat or pulse, hive-like swellings on the skin, puffiness or swelling of the eyelids or around the eyes. If these effects occur, get emergency help at once. Ask someone to drive you to the nearest hospital emergency room. Call an ambulance, lie down, cover yourself to keep warm, and prop your feet higher than your head. Stay in that position until help arrives.
Serious skin reactions can occur during treatment with this medicine. Check with your doctor right away if you have blistering, peeling, or loosening of the skin, red skin lesions, severe acne or skin rash, sores or ulcers on the skin, or fever or chills while you or your child are using this medicine.
Using this medicine during the later part of a pregnancy can harm your unborn baby. If you think you have become pregnant while using the medicine, tell your doctor right away.
This medicine may cause a delay in ovulation for women and may decrease sperm count in men, which can affect their ability to have children. If you plan to have children, talk with your doctor before using this medicine.
Tell your doctor if you have unexplained weight gain or edema (fluid retention or body swelling) with this medicine.
Mobic® oral liquid contains sorbitol which may cause a very serious bowel problem when taken with sodium polystyrene sulfonate (Kayexalate®). Do not take the oral liquid together with Kayexalate®.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.
Common side effects of Vivlodex
Some side effects of meloxicam may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common side effects
- diarrhea
- gas
- heartburn
- indigestion
Less common side effects
- abnormal dreaming
- anxiety
- appetite increased
- bad, unusual, or unpleasant after taste
- belching
- bloated or full feeling
- burning feeling in the chest or stomach
- burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
- burning, dry, or itching eyes
- change in taste
- changes in vision
- confusion
- constipation
- continuing ringing or buzzing or other unexplained noise in the ears
- decreased urination
- discharge
- discouragement
- dry mouth
- excess air or gas in the stomach
- excessive tearing
- feeling of constant movement of self or surroundings
- feeling sad or empty
- general feeling of discomfort or illness
- hair loss
- hearing loss
- hot flushes
- irritability
- loss of interest or pleasure
- nervousness
- pain or burning in the throat
- rapid breathing
- redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
- sensation of spinning
- sleepiness
- sunken eyes
- thinning of the hair
- thirst
- trouble concentrating
- trouble sleeping
- wrinkled skin
Incidence not known
- mood changes
- trouble getting pregnant
Serious side effects of Vivlodex
Along with its needed effects, meloxicam (the active ingredient contained in Vivlodex) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking meloxicam:
Less common side effects
- bleeding gums
- bloating
- blood in the urine
- blurred vision
- burning upper abdominal or stomach pain
- canker sores
- chest tightness or heaviness
- chills
- cloudy urine
- cough
- cramping
- dark urine
- decreased frequency or amount of urine
- difficult or labored breathing
- dilated neck veins
- dizziness
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- general feeling of tiredness and weakness
- headache
- hives or welts
- increased blood pressure
- increased sensitivity of the skin to sunlight
- increased thirst
- irregular breathing
- itching, soreness, or redness other discoloration of the skin
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
- light-colored stools
- loss of appetite
- lower side or back pain
- noisy breathing
- pain or discomfort in the arms, jaw, back, or neck
- painful or difficult urination
- pains in the stomach, side, or abdomen, possibly radiating to the back
- pinpoint red or purple spots on the skin
- pounding in the ears
- seizures
- severe and continuing nausea
- severe sunburn
- shakiness in the legs, arms, hands, or feet
- skin blisters
- sore throat
- sores, ulcers, or white spots on the lips or tongue or inside the mouth
- stomach bloating, burning, cramping, tenderness, or pain
- sweating
- swelling or puffiness of the face
- swollen glands
- trembling or shaking of the hands or feet
- unusual bleeding or bruising
- upper right abdominal or stomach pain
- watery or bloody diarrhea
- weight gain or loss
- yellow eyes or skin
Rare side effects
- area rash
- blistering, peeling, or loosening of the skin
- bloody or black, tarry stools
- clay-colored stools
- cold, clammy skin
- continuing vomiting
- cough
- cracks in the skin
- difficulty with swallowing
- fast, weak pulse
- fever with or without chills
- greatly decreased frequency of urination or amount of urine
- hoarseness
- joint or muscle pain
- lightheadedness
- loss of heat from the body
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- red skin lesions, often with a purple center
- red, irritated eyes
- scaly skin
- severe stomach pain
- tightness in the chest
- unpleasant breath odor
- unusual tiredness or weakness
- vomiting of blood or material that looks like coffee grounds
Incidence not known
- difficulty in passing urine (dribbling)
- difficulty with speaking
- double vision
- inability to move the arms, legs, or facial muscles
- inability to speak
- pains in the chest, groin or legs, especially the calves
- severe headache of sudden onset
- slow speech
- stomach pain, continuing
- sudden loss of coordination
- sudden onset of slurred speech
- sudden vision changes
- swelling of the feet or lower legs
Get emergency help immediately if any of the following symptoms of overdose occur while taking meloxicam:
Symptoms of overdose
- blue lips, fingernails, or skin
- pain in the chest, upper stomach, or throat
- rapid weight gain
- severe stomach pain
- seizures
- slow or fast heartbeat
- swelling around the eyes, face, lips, or tongue
For healthcare professionals
Applies to meloxicam: intravenous dispersion, intravenous solution, oral capsule, oral suspension, oral tablet, oral tablet disintegrating.
General adverse events
The most frequently reported side effects were diarrhea, upper respiratory tract infections, dyspepsia, nausea, abdominal discomfort, and influenza-like symptoms.[Ref]
Gastrointestinal
- Very common (10% or more): Dyspepsia, nausea, vomiting, abdominal pain, constipation, flatulence, diarrhea
- Common (1% to 10%): Abdominal discomfort, gastrointestinal (GI) irritation, aggravated dyspepsia, eructation, gastroesophageal reflux disease, upper abdominal pain
- Uncommon (0.1% to 1%): Occult or macroscopic GI hemorrhage, gastritis, stomatitis
- Rare (0.01% to 0.1%): Colitis, gastroduodenal ulcer, esophagitis
- Very rare (less than 0.01%): GI perforation
- Frequency not reported: Dry mouth, duodenal ulcer, gastric ulcer, gastritis, hematemesis, hemorrhagic duodenal ulcer, hemorrhagic gastric ulcer, intestinal perforation, melena, pancreatitis, perforated duodenal ulcer, perforated gastric ulcer, stomatitis ulcerative[Ref]
Cardiovascular
- Common (1% to 10%): Hypertension
- Uncommon (0.1% to 1%): Flushing
- Rare (less than 0.1%): Palpitations
- Frequency not reported: Hot flushes, angina pectoris, cardiac failure, hypotension, myocardial infarction, vasculitis, arrhythmia, palpitation, tachycardia, shock, cardiac failure[Ref]
Nervous system
- Common (1% to 10%): Dizziness, headache, carpel tunnel syndrome
- Uncommon (0.1% to 1%): Somnolence
- Frequency not reported: Syncope, convulsions, paresthesia, tremor, taste perversion[Ref]
Respiratory
- Common (1% to 10%): Pharyngitis, upper respiratory tract infection, coughing, nasopharyngitis, bronchitis, sinusitis, laryngitis, pleuritic pain, dyspnea, rhinitis
- Rare (less than 0.1%): Asthma
- Frequency not reported: Bronchospasm[Ref]
Other
- Common (1% to 10%): Accident household, edema, fall, influenza-like symptoms, pain, peripheral edema, gravitational edema, fatigue, ear disorder, vertigo, fall
- Frequency not reported: Face edema, fever, malaise, weight decreased, weight increased, tinnitus
- Postmarketing reports: Meningitis[Ref]
Hematologic
- Common (1% to 10%): Anemia
- Rare (0.01% to 0.1%): Blood count abnormal, leukopenia, thrombocytopenia
- Very rare (less than 0.01%): Agranulocytosis[Ref]
Dermatologic
- Common (1% to 10%): Rash, pruritus, erythematous rash, maculopapular rash, hyperhidrosis, purpura
- Uncommon (0.1% to 1%): Angioedema
- Rare (0.01% to 0.1%): Stevens-Johnson syndrome, toxic epidermal necrolysis, urticaria
- Very rare (less than 0.01%): Dermatitis bullous, erythema multiforme
- Frequency not reported: Alopecia, bullous eruption, exfoliative dermatitis, photosensitivity reaction, sweating increased
- Postmarketing reports: Erythema multiforme[Ref]
Hypersensitivity
- Common (1% to 10%): Hypersensitivity
- Uncommon (0.1% to 1%): Allergic reactions
- Frequency not reported: Anaphylactoid reaction
- Postmarketing reports: Anaphylactoid reactions including shock[Ref]
Endocrine
- Postmarketing reports: Female infertility[Ref]
Musculoskeletal
- Common (1% to 10%): Arthralgia, aggravated arthralgia, joint crepitation, joint effusion, joint swelling, back pain, osteoarthritis, pain in extremity, arthritis, bursitis, muscle spasms, myalgia, rheumatoid arthritis[Ref]
Genitourinary
- Common (1% to 10%): Micturition frequency, urinary tract infection, hematuria
- Frequency not reported: Acute urinary retention[Ref]
Hepatic
- Uncommon (0.1% to 1%): Liver function disorder, ALT increased, AST increased, bilirubinemia
- Very rare (less than 0.01%): Hepatitis
- Frequency not reported: GGT increased, jaundice, liver failure[Ref]
Psychiatric
- Common (1% to 10%): Insomnia
- Rare (less than 0.1%): Nightmares, mood alterations
- Frequency not reported: Abnormal dreaming, anxiety, confusion, depression, nervousness, disorientation
- Postmarketing reports: Alterations in mood such as mood elevation[Ref]
Renal
- Very rare (less than 0.01%): Acute renal failure, papillary necrosis, acute tubular necrosis
- Frequency not reported: Albuminuria, BUN increased, creatinine increased, interstitial nephritis, renal failure[Ref]
Metabolic
- Common (1% to 10%): Dehydration, appetite increased
- Uncommon (0.1% to 1%): Sodium retention, hyperkalemia, water retention[Ref]
Ocular
- Common (1% to 10%): Cataract
- Rare (less than 0.1%): Visual disturbances, conjunctivitis, blurred vision
- Frequency not reported: Abnormal vision[Ref]
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References
1. (2001) "Product Information. Mobic (meloxicam)." Boehringer-Ingelheim
2. Cerner Multum, Inc. "Australian Product Information."
3. MHRA. Medicines and Health Regulatory Agency (2013) MHRA Drug Safety Update. http://www.mhra.gov.uk/Safetyinformation/DrugSafetyUpdate
4. (2020) "Product Information. Anjeso (meloxicam)." Baudax Bio, Inc.
Frequently asked questions
- Meloxicam vs Ibuprofen: What's the difference?
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- Which painkiller should you use?
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- Can meloxicam cause drowsiness and headache?
- Is meloxicam a narcotic?
More about Vivlodex (meloxicam)
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Further information
Vivlodex side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.