Vivlodex Side Effects

Generic name: meloxicam

Medically reviewed by Drugs.com. Last updated on Jan 24, 2025.

Note: This document provides detailed information about Vivlodex Side Effects associated with meloxicam. Some dosage forms listed on this page may not apply specifically to the brand name Vivlodex.

Applies to meloxicam: intravenous solution.

Other dosage forms:

• oral capsule, oral suspension, oral tablet, oral tablet disintegrating

Precautions

It is very important that your doctor check your progress closely while you are receiving this medicine to make sure that this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

This medicine may increase your risk of having a heart attack, blood clot, or stroke. This is more likely to occur in people who already have heart and blood vessel disease and who are using this medicine for a long time. Check with your doctor right away if you are having chest pain or discomfort, nausea or vomiting, pain or discomfort in the arms, jaw, back, or neck, trouble breathing, slurred speech, or weakness.

Meloxicam may cause bleeding in your stomach or bowels. This problem can happen without warning signs. This is more likely to occur if you have had a stomach ulcer in the past, if you smoke or drink alcohol regularly, if you are over 60 years of age, are in poor health, or are using certain other medicines (eg, steroids, blood thinner).

Liver problems may occur while you are using this medicine. Check with your doctor right away if you are having more than one of these symptoms: abdominal or stomach pain or tenderness, clay-colored stools, dark urine, decreased appetite, fever, headache, itching, loss of appetite, nausea and vomiting, skin rash, swelling of the feet or lower legs, unusual tiredness or weakness, or yellow eyes or skin.

Check with your doctor right away if you have bloody urine, a decrease in frequency or amount of urine, an increase in blood pressure, increased thirst, loss of appetite, lower back or side pain, nausea, swelling of the face, fingers, or lower legs, troubled breathing, unusual tiredness or weakness, vomiting, or weight gain. These could be symptoms of a serious kidney problem.

Serious side effects can occur during treatment with this medicine and can occur without warning. However, possible warning signs often occur, including severe stomach pain, black tarry stools, vomiting of blood or material that looks like coffee grounds, skin rash, swelling of the face, fingers, feet, or lower legs. Also, signs of serious heart problems could occur such as chest pain, tightness in the chest, fast or irregular heartbeat, or unusual flushing or warmth of the skin. Check with your doctor immediately if you notice any of these warning signs.

Meloxicam may cause a serious type of allergic reaction called anaphylaxis. Although this is rare, it may occur often in patients who are allergic to aspirin or other nonsteroidal anti-inflammatory drugs. Anaphylaxis can be life-threatening and requires immediate medical attention. The most serious signs of this reaction are very fast or irregular breathing, gasping for breath, or fainting. Other signs may include changes in skin color of the face, very fast but irregular heartbeat or pulse, hive-like swellings on the skin, puffiness or swelling of the eyelids or around the eyes. If these effects occur, get emergency help at once. Ask someone to drive you to the nearest hospital emergency room. Call an ambulance, lie down, cover yourself to keep warm, and prop your feet higher than your head. Stay in that position until help arrives.

Serious skin reactions can occur during treatment with this medicine. Check with your doctor right away if you have blistering, peeling, or loosening of the skin, red skin lesions, severe acne or skin rash, sores or ulcers on the skin, or fever or chills while you or your child are using this medicine.

Using this medicine during the later part of a pregnancy can harm your unborn baby. If you think you have become pregnant while using the medicine, tell your doctor right away. This medicine may cause a delay in ovulation for women and may decrease sperm count in men, which can affect their ability to have children. If you plan to have children, talk with your doctor before using this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects of Vivlodex

Along with its needed effects, meloxicam (the active ingredient contained in Vivlodex) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking meloxicam:

Other side effects of Vivlodex

Some side effects of meloxicam may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

See also:

For healthcare professionals

Applies to meloxicam: intravenous dispersion, intravenous solution, oral capsule, oral suspension, oral tablet, oral tablet disintegrating.

General adverse events

The most frequently reported side effects were diarrhea, upper respiratory tract infections, dyspepsia, nausea, abdominal discomfort, and influenza-like symptoms.^[Ref]

Gastrointestinal

• Very common (10% or more): Dyspepsia, nausea, vomiting, abdominal pain, constipation, flatulence, diarrhea
• Common (1% to 10%): Abdominal discomfort, gastrointestinal (GI) irritation, aggravated dyspepsia, eructation, gastroesophageal reflux disease, upper abdominal pain
• Uncommon (0.1% to 1%): Occult or macroscopic GI hemorrhage, gastritis, stomatitis
• Rare (0.01% to 0.1%): Colitis, gastroduodenal ulcer, esophagitis
• Very rare (less than 0.01%): GI perforation
• Frequency not reported: Dry mouth, duodenal ulcer, gastric ulcer, gastritis, hematemesis, hemorrhagic duodenal ulcer, hemorrhagic gastric ulcer, intestinal perforation, melena, pancreatitis, perforated duodenal ulcer, perforated gastric ulcer, stomatitis ulcerative^[Ref]

Cardiovascular

• Common (1% to 10%): Hypertension
• Uncommon (0.1% to 1%): Flushing
• Rare (less than 0.1%): Palpitations
• Frequency not reported: Hot flushes, angina pectoris, cardiac failure, hypotension, myocardial infarction, vasculitis, arrhythmia, palpitation, tachycardia, shock, cardiac failure^[Ref]

Nervous system

• Common (1% to 10%): Dizziness, headache, carpel tunnel syndrome
• Uncommon (0.1% to 1%): Somnolence
• Frequency not reported: Syncope, convulsions, paresthesia, tremor, taste perversion^[Ref]

Respiratory

• Common (1% to 10%): Pharyngitis, upper respiratory tract infection, coughing, nasopharyngitis, bronchitis, sinusitis, laryngitis, pleuritic pain, dyspnea, rhinitis
• Rare (less than 0.1%): Asthma
• Frequency not reported: Bronchospasm^[Ref]

Other

• Common (1% to 10%): Accident household, edema, fall, influenza-like symptoms, pain, peripheral edema, gravitational edema, fatigue, ear disorder, vertigo, fall
• Frequency not reported: Face edema, fever, malaise, weight decreased, weight increased, tinnitus
• Postmarketing reports: Meningitis^[Ref]

Hematologic

• Common (1% to 10%): Anemia
• Rare (0.01% to 0.1%): Blood count abnormal, leukopenia, thrombocytopenia
• Very rare (less than 0.01%): Agranulocytosis^[Ref]

Dermatologic

• Common (1% to 10%): Rash, pruritus, erythematous rash, maculopapular rash, hyperhidrosis, purpura
• Uncommon (0.1% to 1%): Angioedema
• Rare (0.01% to 0.1%): Stevens-Johnson syndrome, toxic epidermal necrolysis, urticaria
• Very rare (less than 0.01%): Dermatitis bullous, erythema multiforme
• Frequency not reported: Alopecia, bullous eruption, exfoliative dermatitis, photosensitivity reaction, sweating increased
• Postmarketing reports: Erythema multiforme^[Ref]

Hypersensitivity

• Common (1% to 10%): Hypersensitivity
• Uncommon (0.1% to 1%): Allergic reactions
• Frequency not reported: Anaphylactoid reaction
• Postmarketing reports: Anaphylactoid reactions including shock^[Ref]

Endocrine

• Postmarketing reports: Female infertility^[Ref]

Musculoskeletal

• Common (1% to 10%): Arthralgia, aggravated arthralgia, joint crepitation, joint effusion, joint swelling, back pain, osteoarthritis, pain in extremity, arthritis, bursitis, muscle spasms, myalgia, rheumatoid arthritis^[Ref]

Genitourinary

• Common (1% to 10%): Micturition frequency, urinary tract infection, hematuria
• Frequency not reported: Acute urinary retention^[Ref]

Hepatic

• Uncommon (0.1% to 1%): Liver function disorder, ALT increased, AST increased, bilirubinemia
• Very rare (less than 0.01%): Hepatitis
• Frequency not reported: GGT increased, jaundice, liver failure^[Ref]

Psychiatric

• Common (1% to 10%): Insomnia
• Rare (less than 0.1%): Nightmares, mood alterations
• Frequency not reported: Abnormal dreaming, anxiety, confusion, depression, nervousness, disorientation
• Postmarketing reports: Alterations in mood such as mood elevation^[Ref]

Renal

• Very rare (less than 0.01%): Acute renal failure, papillary necrosis, acute tubular necrosis
• Frequency not reported: Albuminuria, BUN increased, creatinine increased, interstitial nephritis, renal failure^[Ref]

Metabolic

• Common (1% to 10%): Dehydration, appetite increased
• Uncommon (0.1% to 1%): Sodium retention, hyperkalemia, water retention^[Ref]

Ocular

• Common (1% to 10%): Cataract
• Rare (less than 0.1%): Visual disturbances, conjunctivitis, blurred vision
• Frequency not reported: Abnormal vision^[Ref]

Frequently asked questions

• Meloxicam vs Ibuprofen: What's the difference?
• Should I take meloxicam at night or in the morning?
• Can I take Meloxicam and Aleve or Tylenol together?
• How much meloxicam can I give my dog?
• Is meloxicam very similar to Celebrex?
• Which painkiller should you use?
• How long do I wait after taking ibuprofen to take meloxicam?
• Can meloxicam cause drowsiness and headache?
• Is meloxicam a narcotic?

Further information

Vivlodex side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer