Tedizolid Side Effects

Medically reviewed by Drugs.com. Last updated on Mar 9, 2025.

Applies to tedizolid: oral tablet.

Other dosage forms:

• intravenous powder for solution

Precautions

It is very important that your doctor check your or your child's progress while using this medicine. This will allow your doctor to see if the medicine is working properly and to check for any unwanted effects.

If your or your child's symptoms do not improve or if they become worse, check with your doctor.

This medicine may cause diarrhea, and in some cases it can be severe. It may also occur 2 months or more after you or your child stop using this medicine. If you or your child have diarrhea that continues or gets worse, check with your doctor. Do not take any medicine to treat diarrhea without checking first with your doctor.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Common side effects of tedizolid

Some side effects of tedizolid may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Serious side effects of tedizolid

Along with its needed effects, tedizolid may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking tedizolid:

For healthcare professionals

Applies to tedizolid: intravenous powder for injection, oral tablet.

General adverse events

The most common side effects were nausea, headache, diarrhea, vomiting, and dizziness. Median time to onset was 5 days.^[Ref]

Gastrointestinal

• Common (1% to 10%): Nausea, diarrhea, vomiting
• Uncommon (0.1% to 1%): Clostridioides difficile colitis, oral candidiasis, abdominal pain, constipation, abdominal discomfort, dry mouth, dyspepsia, upper abdominal pain, flatulence, gastroesophageal reflux disease, hematochezia, retching^[Ref]

Nervous system

• Common (1% to 10%): Headache, dizziness, peripheral neuropathy
• Uncommon (0.1% to 1%): Somnolence, dysgeusia, tremor, hypoesthesia, paresthesia
• Frequency not reported: VIIth nerve paralysis^[Ref]

Hematologic

• Common (1% to 10%): Decreased hemoglobin, decreased platelet count
• Uncommon (0.1% to 1%): Decreased absolute neutrophil count, lymphadenopathy, decreased WBC count
• Frequency not reported: Anemia^[Ref]

Decreased hemoglobin (less than 10.1 g/dL in males; less than 9 g/dL in females), platelet count (less than 112 x 10[3]/mm3), and absolute neutrophil count (less than 0.8 x 10[3]/mm3) were reported in 3.4%, 2.1%, and 0.4% of patients, respectively.^[Ref]

Dermatologic

• Common (1% to 10%): Generalized pruritus
• Uncommon (0.1% to 1%): Dermatophytosis, pruritus, urticaria, hyperhidrosis, rash, alopecia, erythematous rash, generalized rash, acne, allergic pruritus, maculopapular rash, popular rash, pruritic rash
• Frequency not reported: Dermatitis^[Ref]

Other

• Common (1% to 10%): Fatigue
• Uncommon (0.1% to 1%): Fungal infection, abscess, flushing, hot flush, chills, pyrexia, peripheral edema, grip strength decreased

Local

• Common (1% to 10%): Infusion/injection-related side effects (including but not limited to phlebitis, injection/infusion-site pain, injection/infusion-site swelling, injection-site reaction, injection-site erythema, injection-site induration, infusion-related reaction), infusion site reactions (phlebitis)
• Uncommon (0.1% to 1%): Infusion-related reactions, infusion site pain^[Ref]

Cardiovascular

• Uncommon (0.1% to 1%): Bradycardia
• Frequency not reported: Palpitations, tachycardia, hypertension^[Ref]

Hepatic

• Uncommon (0.1% to 1%): Elevated hepatic transaminases
• Frequency not reported: Increased ALT, increased AST, increased GGT, abnormal liver function tests^[Ref]

Psychiatric

• Uncommon (0.1% to 1%): Insomnia, sleep disorder, anxiety, nightmare, irritability^[Ref]

Hypersensitivity

• Uncommon (0.1% to 1%): Drug hypersensitivity

Musculoskeletal

• Uncommon (0.1% to 1%): Arthralgia, muscle spasms, back pain, limb discomfort, neck pain

Metabolic

• Uncommon (0.1% to 1%): Dehydration, inadequately controlled diabetes mellitus, hyperkalemia

Ocular

• Uncommon (0.1% to 1%): Optic nerve disorders, blurred vision, vitreous floaters
• Frequency not reported: Asthenopia, visual impairment^[Ref]

Respiratory

• Uncommon (0.1% to 1%): Respiratory tract infection, cough, nasal dryness, pulmonary congestion

Genitourinary

• Uncommon (0.1% to 1%): Vulvovaginal mycotic infection, vulvovaginal candidiasis, abnormal urine odor, vulvovaginal pruritus

See also:

Further information

Tedizolid side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer