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Tedizolid Side Effects

In Summary

More frequently reported side effects include: diarrhea. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to tedizolid: oral tablet

As well as its needed effects, tedizolid may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking tedizolid, check with your doctor immediately:

Less common or rare:
  • Abdominal or stomach tenderness
  • back pain
  • blurred vision
  • chest tightness
  • chills
  • dizziness
  • fast, pounding, or irregular heartbeat or pulse
  • fever
  • headache
  • hives or welts, itching, or skin rash
  • hoarseness
  • joint pain, stiffness, or swelling
  • nausea and vomiting
  • nervousness
  • pale skin
  • pounding in the ears
  • redness of the skin
  • severe abdominal or stomach cramps and pain
  • slow or fast heartbeat
  • swelling of the eyelids, face, lips, hands, or feet
  • tightness in the chest
  • troubled breathing or swallowing
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • watery or severe diarrhea, which may also be bloody

Minor Side Effects

Some tedizolid side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Less common:
  • Burning, numbness, tingling, or painful sensations
  • diarrhea
  • unsteadiness or awkwardness
  • weakness in the arms, hands, legs, or feet
Less common or rare:
  • Blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • change in vision
  • feeling of warmth
  • redness of the face, neck, arms, and occasionally, upper chest
  • seeing floating spots before the eyes
  • sore mouth or tongue
  • trouble sleeping
  • white patches in the mouth or on the tongue

For Healthcare Professionals

Applies to tedizolid: intravenous powder for injection, oral tablet

General

The most common adverse reactions were nausea, headache, diarrhea, vomiting, and dizziness. Median time to onset was 5 days.[Ref]

Gastrointestinal

Common (1% to 10%): Nausea, diarrhea, vomiting[Ref]

Cardiovascular

Frequency not reported: palpitations, tachycardia, hypertension[Ref]

Palpitations, tachycardia, and hypertension were reported at a rate of less than 2%.[Ref]

Dermatologic

Frequency not reported: Dermatitis, flushing, pruritus, urticaria[Ref]

Dermatitis, flushing, pruritus, and urticaria were reported at a rate of less than 2%.[Ref]

Hematologic

Anemia and decreased WBC count were reported at a rate of less than 2%. Decreases in hemoglobin (less than 10 g/dL in males and less than 9 g/dL in females) platelet count (less than 112 x 10(3)/mm(3)) and absolute neutrophil count (less than 0.8 x 10(3)/mm(3)) were reported in 3.1%, 2.3%, and 0.5%, respectively.[Ref]

Frequency not reported: Anemia, decreased WBC count[Ref]

Hepatic

Frequency not reported: Hepatic transaminase elevations[Ref]

Hepatic transaminase elevations were reported at a rate of less than 2%.[Ref]

Immunologic

Drug hypersensitivity, Clostridium difficile colitis, oral candidiasis, and vulvovaginal mycotic infection were reported at a rate of less than 2%.[Ref]

Frequency not reported: Drug hypersensitivity, Clostridium difficile colitis, oral candidiasis, vulvovaginal mycotic infection[Ref]

Local

Frequency not reported: Infusion-related reactions[Ref]

Infusion-related reactions were reported at a rate of less than 2%.[Ref]

Nervous system

Frequency not reported: Hypoesthesia, paresthesia, VIIth nerve paralysis[Ref]

Hypoesthesia, paresthesia, and VIIth nerve paralysis were reported at a rate of less than 2%.[Ref]

Ocular

Frequency not reported: Asthenopia, blurred vision, visual impairment, vitreous floaters[Ref]

Asthenopia, blurred vision, visual impairment, and vitreous floaters were reported at a rate of less than 2%.[Ref]

Psychiatric

Insomnia was reported at a rate of less than 2%.[Ref]

Frequency not reported: Insomnia[Ref]

References

1. "Product Information. Sivextro (tedizolid)." Cubist Pharmaceuticals Inc, Lexington, MA.

It is possible that some side effects of tedizolid may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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