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Generic Name: tedizolid (oral/injection) (te DIZ oh lid)
Brand Names: Sivextro

Medically reviewed by Last updated on Mar 4, 2019.

What is Sivextro?

Sivextro (tedizolid) is an antibiotic that fights bacteria.

Sivextro is used to treat skin infections in adults, including "MRSA" staph infections.

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Sivextro and other antibacterial drugs, this medicine should only be used to treat infections that are proven or strongly suspected to be caused by susceptible bacteria.

Important information

Sivextro should only be used to treat bacterial infections. Tedizolid does not treat viral infections (e.g., the common cold).

While it is common to feel better early in the course of therapy, Sivextro should be taken exactly as directed. Skipping doses or not completing the full course of therapy may decrease the effectiveness of the immediate treatment and increase the likelihood that bacteria will develop resistance and will not be treatable in the future.

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

You should not use Sivextro if you are allergic to tedizolid.

To make sure Sivextro is safe for you, tell your doctor if you have recently been sick with a fever, cold or flu symptoms, cough, or sore throat.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Tedizolid can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Sivextro is not approved for use by anyone younger than 18 years old.

How should I use Sivextro?

Use Sivextro exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

The oral form of Sivextro is a tablet taken by mouth. You may take the tablet with or without food.

Sivextro injection into a vein through an IV. You may be shown how to use an IV at home. Do not give yourself this medicine if you do not understand how to use the injection and properly dispose of needles, IV tubing, and other items used.

Sivextro injection is a powder medicine that must be mixed with a liquid (diluent) in an IV bag before using it. If you are using the injections at home, be sure you understand how to properly mix and store the medicine. Use only the diluent provided with your medicine.

Gently swirl but do not shake the mixed medicine or it may foam. Do not use if the medicine has changed colors or has particles in it. Call your pharmacist for new medicine.

After mixing Sivextro injection, you may store the mixture for up to 24 hours at room temperature or in a refrigerator.

Each single-use injection vial (bottle) is for one use only. Throw away after one use, even if there is still some medicine left in it after injecting your dose.

Use a disposable needle and syringe only once. Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof "sharps" disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets.

Use Sivextro for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Tedizolid will not treat a viral infection such as the flu or a common cold.

Do not share this medicine with another person, even if they have the same symptoms you have.

Store this medicine at room temperature away from moisture and heat. Keep each tablet in its blister pack until you are ready to take it. Prepare your injection dose only when you are ready to give an injection.

Sivextro dosing information

Usual Adult Dose for Bacterial Infection:

Oral: 200 mg orally once daily for 6 days
Parenteral: 200 mg IV infusion once daily for 6 days

Comments: No dose adjustment is needed when switching from IV to oral.

Uses: Acute bacterial skin and skin structure infections caused by susceptible isolates of S. aureus (including methicillin-resistant (MRSA) and methicillin-susceptible (MSSA ) isolates), S. pyogenes, S. agalactiae, S. anginosus, and E faecalis.

What happens if I miss a dose?

Take or use the missed dose as soon as you remember. Skip the missed dose if your next dose is less than 8 hours away. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using Sivextro?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

Sivextro side effects

Get emergency medical help if you have signs of an allergic reaction to Sivextro: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • severe stomach pain, diarrhea that is watery or bloody;

  • numbness or tingling in your hands or feet; or

  • vision problems, severe headache or pain behind your eyes.

Common Sivextro side effects may include:

  • nausea, vomiting, diarrhea;

  • headache; or

  • dizziness.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Sivextro?

Tell your doctor about all your current medicines and any you start or stop using, especially:

  • methotrexate;

  • rosuvastatin (Crestor); or

  • topotecan.

This list is not complete. Other drugs may interact with tedizolid, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Sivextro only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.