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Sivextro Side Effects

Generic Name: tedizolid

Note: This document contains side effect information about tedizolid. Some of the dosage forms listed on this page may not apply to the brand name Sivextro.

For the Consumer

Applies to tedizolid: oral tablet

Along with its needed effects, tedizolid (the active ingredient contained in Sivextro) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking tedizolid:

Less common or rare
  • Abdominal or stomach tenderness
  • back pain
  • blurred vision
  • chest tightness
  • chills
  • dizziness
  • fast, pounding, or irregular heartbeat or pulse
  • fever
  • headache
  • hives or welts, itching, or skin rash
  • hoarseness
  • joint pain, stiffness, or swelling
  • nausea and vomiting
  • nervousness
  • pale skin
  • pounding in the ears
  • redness of the skin
  • severe abdominal or stomach cramps and pain
  • slow or fast heartbeat
  • swelling of the eyelids, face, lips, hands, or feet
  • tightness in the chest
  • troubled breathing or swallowing
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • watery or severe diarrhea, which may also be bloody

Some side effects of tedizolid may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Burning, numbness, tingling, or painful sensations
  • diarrhea
  • unsteadiness or awkwardness
  • weakness in the arms, hands, legs, or feet
Less common or rare
  • Blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • change in vision
  • feeling of warmth
  • redness of the face, neck, arms, and occasionally, upper chest
  • seeing floating spots before the eyes
  • sore mouth or tongue
  • trouble sleeping
  • white patches in the mouth or on the tongue

For Healthcare Professionals

Applies to tedizolid: intravenous powder for injection, oral tablet


The most common adverse reactions were nausea, headache, diarrhea, vomiting, and dizziness. Median time to onset was 5 days.[Ref]


Common (1% to 10%): Nausea, diarrhea, vomiting[Ref]


Frequency not reported: palpitations, tachycardia, hypertension[Ref]

Palpitations, tachycardia, and hypertension were reported at a rate of less than 2%.[Ref]


Frequency not reported: Dermatitis, flushing, pruritus, urticaria[Ref]

Dermatitis, flushing, pruritus, and urticaria were reported at a rate of less than 2%.[Ref]


Anemia and decreased WBC count were reported at a rate of less than 2%. Decreases in hemoglobin (less than 10 g/dL in males and less than 9 g/dL in females) platelet count (less than 112 x 10(3)/mm(3)) and absolute neutrophil count (less than 0.8 x 10(3)/mm(3)) were reported in 3.1%, 2.3%, and 0.5%, respectively.[Ref]

Frequency not reported: Anemia, decreased WBC count[Ref]


Frequency not reported: Hepatic transaminase elevations[Ref]

Hepatic transaminase elevations were reported at a rate of less than 2%.[Ref]


Drug hypersensitivity, Clostridium difficile colitis, oral candidiasis, and vulvovaginal mycotic infection were reported at a rate of less than 2%.[Ref]

Frequency not reported: Drug hypersensitivity, Clostridium difficile colitis, oral candidiasis, vulvovaginal mycotic infection[Ref]


Frequency not reported: Infusion-related reactions[Ref]

Infusion-related reactions were reported at a rate of less than 2%.[Ref]

Nervous system

Frequency not reported: Hypoesthesia, paresthesia, VIIth nerve paralysis[Ref]

Hypoesthesia, paresthesia, and VIIth nerve paralysis were reported at a rate of less than 2%.[Ref]


Frequency not reported: Asthenopia, blurred vision, visual impairment, vitreous floaters[Ref]

Asthenopia, blurred vision, visual impairment, and vitreous floaters were reported at a rate of less than 2%.[Ref]


Insomnia was reported at a rate of less than 2%.[Ref]

Frequency not reported: Insomnia[Ref]


1. "Product Information. Sivextro (tedizolid)." Cubist Pharmaceuticals Inc, Lexington, MA.

Some side effects of Sivextro may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.