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Tedizolid Dosage

Medically reviewed on January 17, 2017.

Applies to the following strengths: 200 mg

Usual Adult Dose for Skin and Structure Infection

200 mg IV or orally once a day for 6 days

Use: For the treatment of acute bacterial skin and skin structure infections due to susceptible isolates of Staphylococcus aureus (including methicillin-resistant and methicillin-susceptible isolates), Streptococcus pyogenes, S agalactiae, S anginosus group (including S anginosus, S intermedius, and S constellatus), Enterococcus faecalis

Renal Dose Adjustments

No adjustment recommended.

Liver Dose Adjustments

No adjustment recommended.

Precautions

CONTRAINDICATIONS: None

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Hemodialysis: No adjustment recommended.
Peritoneal dialysis: Data not available

Other Comments

Administration advice:
-IV: Administer via IV infusion over 1 hour; do not administer as IV push or bolus. This drug is not for intra-arterial, IM, intrathecal, intraperitoneal, or subcutaneous administration.
-IV: Do not mix with other agents during administration; if the same IV line is used for sequential infusion of several drugs, flush the line with a compatible infusion solution before and after infusion of this drug.
-Do not adjust dose when switching from IV to oral administration (no adjustments needed).
-Oral: Administer with or without food; no dietary restrictions.
-If a dose is missed, administer as soon as possible anytime up to 8 hours before the next scheduled dose; if less than 8 hours from next dose, wait until next scheduled dose.

Storage requirements:
-IV: Total time from reconstitution to administration should not exceed 24 hours at room temperature or refrigerated at 2C to 8C (36F to 46F).

Reconstitution/preparation techniques:
-IV formulation: Must be reconstituted and then diluted; the manufacturer product information should be consulted.

IV compatibility:
-Compatible diluents and IV solutions: Sterile Water for Injection; 0.9% Sodium Chloride Injection, USP
-Incompatible: Any solution containing divalent cations (e.g., calcium, magnesium), including Lactated Ringers Injection and Hartmann's Solution
-Limited data available on compatibility of this drug with other IV substances, additives, or other drugs; they should not be added to tedizolid single-use vials or infused simultaneously.

General:
-To reduce the development of drug-resistant organisms and maintain effective therapy, this drug should be used only to treat infections proven or strongly suspected to be caused by susceptible bacteria.
-Culture and susceptibility information should be considered when selecting/modifying antibacterial therapy or, if no data are available, local epidemiology and susceptibility patterns may be considered when selecting empiric therapy.

Patient advice:
-Read the US FDA-approved Patient Information.
-Avoid missing doses and complete the entire course of therapy.
-Consult physician at once if watery and bloody stools (with or without stomach cramps and fever) develop.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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