Nuzyra Side Effects
Generic name: omadacycline
Medically reviewed by Drugs.com. Last updated on Oct 23, 2022.
Note: This document contains side effect information about omadacycline. Some dosage forms listed on this page may not apply to the brand name Nuzyra.
Applies to omadacycline: oral tablet. Other dosage forms:
Serious side effects of Nuzyra
Along with its needed effects, omadacycline (the active ingredient contained in Nuzyra) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking omadacycline:
- Blurred vision
- fast, pounding, or irregular heartbeat or pulse
- hives, itching, skin rash
- itching of the vagina or genitals
- joint pain, stiffness, or swelling
- pale skin
- pounding in the ears
- redness of the skin
- sore mouth or tongue
- stomach pain
- swelling of the eyelids, face, lips, hands, or feet
- thick, white vaginal discharge with mild or no odor
- tightness in the chest
- troubled breathing or swallowing
- troubled breathing with exertion
- unusual bleeding or bruising
- unusual tiredness or weakness
- white patches in the mouth or on the tongue
Other side effects of Nuzyra
Some side effects of omadacycline may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- change or loss in taste
- feeling of constant movement of self or surroundings
- increased sweating
- mouth or throat pain
- sensation of spinning
- stomach discomfort or upset
- trouble sleeping
- unusual drowsiness, dullness, or feeling of sluggishness
For Healthcare Professionals
Applies to omadacycline: intravenous powder for injection, oral tablet.
In the community-acquired bacterial pneumonia clinical trial, serious side effects were reported in 6% of patients treated with this drug and 6.7% of patients treated with moxifloxacin; therapy was discontinued due to any side effect in 5.5% of patients treated with this drug and 7% of patients treated with moxifloxacin. In the pooled acute bacterial skin and skin structure infection trials, serious side effects were reported in 2.3% of patients treated with this drug and 1.9% of patients treated with comparator; therapy was discontinued due to side effects in 1.7% of patients treated with this drug and 1.5% of patients treated with comparator.[Ref]
Very common (10% or more): Nausea (up to 30%), vomiting (up to 17%)
Common (1% to 10%): Diarrhea, constipation
Common (1% to 10%): Increased ALT, increased AST, increased GGT
Frequency not reported: Increased bilirubin[Ref]
Common (1% to 10%): Hypertension
Common (1% to 10%): Headache
In the community-acquired bacterial pneumonia clinical trial, mortality imbalance was observed with 8 deaths (2%) in patients treated with this drug compared to 4 deaths (1%) in patients treated with moxifloxacin. All deaths (both treatment groups) occurred in patients older than 65 years; most patients had multiple comorbidities. Causes of death varied and included worsening and/or complications of infection and underlying conditions. The cause of the mortality imbalance has not been established.
Common (1% to 10%): Death
Frequency not reported: Hypersensitivity[Ref]
Frequency not reported: Oropharyngeal pain[Ref]
Frequency not reported: Vulvovaginal mycotic infection[Ref]
Frequently asked questions
More about Nuzyra (omadacycline)
- Check interactions
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- Dosage information
- During pregnancy
- FDA approval history
- Drug class: tetracyclines
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Related treatment guides
1. "Product Information. Nuzyra (omadacycline)." Paratek Pharmaceuticals, Inc. (2018):
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.