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Nuzyra (oral/injection)

Generic name: omadacycline (oral/injection) [ oh-MA-da-SYE-kleen ]
Drug class: Tetracyclines

Medically reviewed by on May 3, 2022. Written by Cerner Multum.

What is Nuzyra?

Nuzyra is a tetracycline antibiotic that is used to treat pneumonia or skin infections caused by bacteria.

Nuzyra may also be used for purposes not listed in this medication guide.


Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

You should not use Nuzyra if you are allergic to Nuzyra or similar antibiotics such as demeclocycline, doxycycline, minocycline, sarecycline, tetracycline, or tigecycline.

Using Nuzyra during pregnancy may affect tooth and bone development in the unborn baby. Using this medicine during the last half of pregnancy can cause permanent tooth discoloration later in the baby's life. Use effective birth control to prevent pregnancy, and tell your doctor if you become pregnant.

Omadacycline can pass into breast milk and may affect bone and tooth development in a nursing infant. Do not breastfeed while you are using omadacycline and for at least 4 days after your last dose.

Nuzyra is not approved for use by anyone younger than 18 years old. This medicine can cause permanent yellowing or graying of the teeth in children.

How is Nuzyra given?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Nuzyra oral is taken by mouth. Take the tablets with water on an empty stomach, at least 4 hours after you last ate or drank anything other than water.

For at least 2 hours after taking the tablets: do not eat or drink anything except water.

For at least 4 hours after taking the tablets:

Nuzyra injection is given as an infusion into a vein. A healthcare provider will give your first dose and may teach you how to properly use the medication by yourself.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you don't understand all instructions.

Nuzyra injection must be mixed with a liquid (diluent) in an IV bag before using it. The injection must be given slowly, and the infusion can take 30 to 60 minutes to complete. Do not use if the medicine has changed colors or has particles in it. Call your pharmacist for new medicine.

Store the tablets at room temperature away from moisture and heat. You may store the IV bag at room temperature for up to 24 hours.

You may also store the IV bag in a refrigerator for up to 48 hours. Take the bag out of the refrigerator and let it reach room temperature for 60 minutes before injecting your dose. Keep the bag in an upright position.

Do not freeze this medicine.

Use a needle and syringe only once and then place them in a puncture-proof "sharps" container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.

Use Nuzyra for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses can increase your risk of infection that is resistant to medication. This medicine will not treat a viral infection such as the flu or a common cold.

What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using Nuzyra?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine.

Nuzyra could make you sunburn more easily. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

Nuzyra side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Nuzyra may cause serious side effects. Call your doctor at once if you have:

  • little or no urination; or

  • increased pressure inside the skull--severe headaches, ringing in your ears, dizziness, nausea, vision problems, pain behind your eyes.

Common side effects of Nuzyra may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Nuzyra?

Tell your doctor about all your other medicines, especially:

This list is not complete. Other drugs may affect Nuzyra, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Frequently asked questions

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.