Generic name: omadacycline (oral/injection) [ oh-MA-da-SYE-kleen ]
Brand name: Nuzyra
Drug class: Tetracyclines

Medically reviewed by Drugs.com on Aug 28, 2023. Written by Cerner Multum.

What is Nuzyra?

Nuzyra is a tetracycline antibiotic that is used in adults to treat pneumonia or skin infections caused by bacteria.

Nuzyra may also be used for purposes not listed in this medication guide.

Nuzyra side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Some side effects may occur during the injection. Tell your medical caregivers if you feel dizzy, nauseated, light-headed, itchy, sweaty, or have a headache, chest tightness, back pain, trouble breathing, or swelling in your face.

Nuzyra may cause serious side effects. Call your doctor at once if you have:

• signs of metabolic acidosis--confusion, vomiting, lack of energy, irregular heartbeats;

• signs of liver or pancreas problems--loss of appetite, upper stomach pain (that may spread to your back), nausea or vomiting, fast heart rate, dark urine, jaundice (yellowing of the skin or eyes); or

• increased pressure inside the skull--severe headaches, ringing in your ears, dizziness, nausea, vision problems, pain behind your eyes.

Common side effects of Nuzyra may include:

• pain, irritation, redness, swelling, hard lump (induration) where the injection was given;

• nausea, vomiting, diarrhea, constipation;

• headache;

• trouble sleeping;

• high blood pressure; or

• abnormal liver function tests.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Warnings

Use only as directed. Tell your doctor if you use other medicines or have other medical conditions or allergies.

Before taking this medicine

You should not use Nuzyra if you are allergic to Nuzyra or similar medicines such as: demeclocycline, doxycycline, minocycline, sarecycline, tetracycline, or tigecycline.

Pregnancy may be less likely to occur while the mother or the father is using this medicine. Both men and women should still use birth control to prevent pregnancy because the medicine can harm an unborn baby.

May harm an unborn baby. Use birth control and tell your doctor if you become pregnant. Taking Nuzyra during pregnancy may affect tooth and bone development in the unborn baby. Taking this medicine during the second and third trimesters of pregnancy can cause permanent tooth discoloration later in life. Tell your doctor if you are pregnant or plan to become pregnant.

Omadacycline can pass into breast milk and may harm a nursing baby. You should not breastfeed while taking this medicine and for at least 4 days after your last dose.

How should I use Nuzyra?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Nuzyra oral is taken by mouth. Take the tablets with water on an empty stomach, at least 4 hours after your last meal or drink other than water.

For at least 2 hours after taking the tablets: do not eat or drink anything except water.

For at least 4 hours after taking the tablets:

• Do not eat or drink any dairy product such as milk, cheese, or yogurt.

• Do not take a vitamin or mineral supplement that contains iron.

• Do not take an antacid (including Maalox, Milk of Magnesia, Mylanta, Pepcid Complete, Rolaids, Tums, Pepto-Bismol, and others).

Nuzyra injection is given as an infusion into a vein. A healthcare provider may give you this injection or may teach you how to properly use this medicine by yourself.

Prepare an injection only when you are ready to give it. Call your pharmacist if the medicine looks cloudy, has changed colors or has particles in it. Ask your doctor or pharmacist if you don't understand how to use an injection.

Be sure you understand how to properly mix this medicine with a liquid (diluent) and how to store the mixture.

Store the tablet tightly closed at room temperature, away from moisture and heat.

Antibiotic medicines can cause diarrhea. Tell your doctor if you have diarrhea that is watery or bloody.

Keep using this medicine even if your symptoms quickly improve. Skipping doses could make your infection resistant to medication. Nuzyra will not treat a viral infection (flu or a common cold).

What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using Nuzyra?

Nuzyra could make you sunburn more easily. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

What other drugs will affect Nuzyra?

Tell your doctor about all your other medicines, especially:

• antacids that contain calcium, magnesium, aluminum, or bismuth subsalicylate (Pepto-Bismol);

• multivitamin or mineral supplement that contains iron or calcium; or

• a blood thinner (warfarin, Coumadin, Jantoven).

This list is not complete. Other drugs may affect Nuzyra, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Related/similar drugs

amoxicillin, doxycycline, cephalexin, ciprofloxacin, azithromycin, metronidazole, clindamycin

Frequently asked questions

• What type of drug is Nuzyra (omadacycline)?

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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