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Demeclocycline

Generic Name: demeclocycline (DEM e kloe SYE kleen)
Brand Name: Declomycin

Medically reviewed by Drugs.com on Dec 17, 2018 – Written by Cerner Multum

What is demeclocycline?

Demeclocycline is a tetracycline antibiotic. It fights bacteria in the body.

Demeclocycline is used to treat many different bacterial infections, such as urinary tract infections, acne, gonorrhea, chlamydia, and others.

Demeclocycline may also be used for purposes not listed in this medication guide.

Important Information

You should not take this medication if you are allergic to demeclocycline or to similar antibiotics such as doxycycline (Adoxa, Alodox, Avidoxy, Oraxyl, Doryx, Oracea, Vibramycin), minocycline (Dynacin, Minocin, Solodyn), or tetracycline (Ala-Tet, Brodspec, Panmycin, Sumycin, Tetracap).

Do not use demeclocycline if you are pregnant. It could harm the unborn baby or cause permanent tooth discoloration later in life.

Demeclocycline can make birth control pills less effective. Ask your doctor about using a non-hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while taking demeclocycline.

Demeclocycline passes into breast milk and may affect bone and tooth development in a nursing baby. You should not breast-feed while you are taking demeclocycline.

Do not give demeclocycline to a child younger than 8 years old. Demeclocycline can affect a child's growth or cause permanent yellowing or graying of the teeth.

Avoid exposure to sunlight or tanning beds. Demeclocycline can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

Do not take iron supplements, multivitamins, calcium supplements, antacids, or laxatives within 2 hours before or after taking demeclocycline. Also avoid a product that contains bismuth subsalicylate (such as Pepto-Bismol) within 2 hours before or after taking demeclocycline. These medications can make it harder for your body to absorb demeclocycline.

Throw away any unused demeclocycline after the expiration date on the label has passed.

Before taking this medicine

You should not take this medication if you are allergic to demeclocycline or to similar antibiotics such as doxycycline (Adoxa, Alodox, Avidoxy, Oraxyl, Doryx, Oracea, Vibramycin), minocycline (Dynacin, Minocin, Solodyn), or tetracycline (Ala-Tet, Brodspec, Panmycin, Sumycin, Tetracap).

To make sure you can safely take demeclocycline, tell your doctor if you have any of these other conditions:

If you are being treated for gonorrhea, your doctor may test you to make sure you do not also have syphilis, another sexually transmitted disease.

FDA pregnancy category D. Do not use demeclocycline if you are pregnant. It could harm the unborn baby or cause permanent tooth discoloration later in life. Use effective birth control, and tell your doctor if you become pregnant during treatment.

Demeclocycline can make birth control pills less effective. Ask your doctor about using a non-hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while taking demeclocycline.

Demeclocycline passes into breast milk and may affect bone and tooth development in a nursing baby. You should not breast-feed while you are taking demeclocycline.

Do not give demeclocycline to a child younger than 8 years old. Demeclocycline can affect a child's growth or cause permanent yellowing or graying of the teeth.

How should I take demeclocycline?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Take demeclocycline on an empty stomach, at least 1 hour before or 2 hours after a meal.

Take this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Demeclocycline is usually given for up to 2 days after lab tests show that the infection has cleared. Demeclocycline will not treat a viral infection such as the common cold or flu.

Do not share this medication with another person, even if they have the same symptoms you have.

If you take this medication long-term, your blood will need to be tested often. Your kidney and liver function may also need to be tested. Visit your doctor regularly.

Store at room temperature away from moisture, heat, and light. Throw away any unused demeclocycline after the expiration date on the label has passed.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking demeclocycline?

Do not take demeclocycline with milk or other dairy products, unless your doctor has told you to. Dairy products can make it harder for your body to absorb the medicine.

Demeclocycline may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Avoid exposure to sunlight or tanning beds. Demeclocycline can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

Do not take iron supplements, multivitamins, calcium supplements, antacids, or laxatives within 2 hours before or after taking demeclocycline. Also avoid a product that contains bismuth subsalicylate (such as Pepto-Bismol) within 2 hours before or after taking demeclocycline. These medications can make it harder for your body to absorb demeclocycline.

Demeclocycline side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using demeclocycline and call your doctor at once if you have a serious side effect such as:

  • fever, chills, body aches, flu symptoms;

  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;

  • pale skin, dark colored urine, jaundice (yellowing of the skin or eyes);

  • confusion, mood changes, weakness, increased thirst or urination;

  • swelling, weight gain, urinating less than usual or not at all;

  • chest pain, wheezing, dry cough, rapid breathing, feeling short of breath;

  • severe tingling, numbness, pain, muscle weakness;

  • headache, ringing in your ears, dizziness, nausea, vision problems, pain behind your eyes;

  • sore throat and headache with a severe blistering, peeling, and red skin rash; or

  • severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate.

Less serious side effects may include:

  • sores or swelling in your rectal or genital area;

  • mild nausea, vomiting, diarrhea, loss of appetite;

  • white patches or sores inside your mouth or on your lips;

  • swollen tongue, trouble swallowing; or

  • vaginal itching or discharge.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Demeclocycline dosing information

Usual Adult Dose for SIADH:

(Not approved by FDA)

Initial dose: 600 to 1200 mg/day orally in 3 or 4 divided doses
Maintenance dose: 600 to 900 mg/day orally or the lowest effective dosage to prevent hyponatremia

Usual Adult Dose for Bacterial Infection:

150 mg orally 4 times a day or 300 mg orally twice a day

Usual Pediatric Dose for Bacterial Infection:

Above 8 years of age: 7 to 13 mg/kg/day orally divided in 2 to 4 doses
Maximum dose: 600 mg/day

What other drugs will affect demeclocycline?

Tell your doctor about all other medicines you use, especially:

This list is not complete and other drugs may interact with demeclocycline. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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