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Methyclothiazide Side Effects

Medically reviewed by Last updated on Sep 19, 2023.

Applies to methyclothiazide: oral tablet.

Serious side effects of Methyclothiazide

Along with its needed effects, methyclothiazide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking methyclothiazide:

Incidence not known

Other side effects of Methyclothiazide

Some side effects of methyclothiazide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

For Healthcare Professionals

Applies to methyclothiazide: compounding powder, oral tablet.


Frequency not reported: Pancreatitis, sialadenitis, vomiting, diarrhea, nausea, gastric irritation, constipation[Ref]


Frequency not reported: Cutaneous vasculitis, purpura, urticaria, rash, photosensitivity[Ref]


Frequency not reported: Aplastic anemia, hemolytic anemia, agranulocytosis, leukopenia, thrombocytopenia[Ref]


Frequency not reported: Anorexia, hyperglycemia, hyperuricemia, electrolyte imbalance, hypercalcemia[Ref]

Nervous system

Frequency not reported: Headache, vertigo, dizziness, paresthesias[Ref]


Frequency not reported: Respiratory distress, pneumonitis, pulmonary edema[Ref]


Frequency not reported: Orthostatic hypotension, vasculitis[Ref]


Frequency not reported: Anaphylactic reaction, Stevens-Johnson syndrome[Ref]


Frequency not reported: Cramping, muscle spasm[Ref]


Frequency not reported: Transient blurred vision, xanthopsia[Ref]


Frequency not reported: Weakness, fever[Ref]


Frequency not reported: Glycosuria[Ref]


Frequency not reported: Intrahepatic cholestatic jaundice[Ref]


Frequency not reported: Restlessness[Ref]


1. (2001) "Product Information. Enduron (methyclothiazide)." Abbott Pharmaceutical

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.