Methyclothiazide Side Effects

Medically reviewed by Drugs.com. Last updated on Sep 19, 2023.

Applies to methyclothiazide: oral tablet.

Serious side effects of methyclothiazide

Along with its needed effects, methyclothiazide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking methyclothiazide:

Incidence not known

• abdominal or stomach pain
• back, leg, or stomach pains
• black, tarry stools
• bleeding gums
• blistering, peeling, or loosening of skin
• bloating
• blood in urine or stools
• bloody urine
• blue lips and fingernails
• blurred vision
• burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• chest pain
• chills
• clay-colored stools
• cloudy urine
• cold sweats
• confusion
• constipation
• cough or hoarseness
• coughing that sometimes produces a pink frothy sputum
• coughing up blood
• cracks in the skin
• darkened urine
• decrease in urine output or decrease in urine-concentrating ability
• decreased frequency or amount of urine
• diarrhea
• difficult, fast, or noisy breathing, sometimes with wheezing
• difficulty swallowing
• dizziness, faintness, or lightheadedness when getting up from lying or sitting position
• dry mouth
• fast or irregular heartbeat
• fever
• flushed, dry skin
• fruit-like breath odor
• general body swelling
• general feeling of discomfort or illness
• general feeling of tiredness or weakness
• greatly decreased frequency of urination or amount of urine
• headache
• hives
• increased blood pressure
• increased hunger
• increased sweating
• increased thirst
• increased urination
• indigestion
• itching
• joint pain, stiffness, or swelling
• loss of appetite
• loss of heat from the body
• lower back or side pain
• muscle cramps or pain
• nausea or vomiting
• nosebleeds
• numbness, tingling, pain, or weakness in hands or feet
• pain in joints or muscles
• painful or difficult urination
• pains in stomach, side, or abdomen, possibly radiating to the back
• pale skin
• pinpoint red spots on skin
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• rash
• red, irritated eyes
• red skin lesions, often with a purple center
• red, swollen skin
• redness, soreness, or itching skin
• scaly skin
• seizures
• shortness of breath
• sore throat
• sores, ulcers, or white spots on lips or in mouth
• sores, welting or blisters
• sugar in the urine
• swelling of face, fingers, legs, ankles, feet, or lower legs
• swollen or painful glands
• tenderness of salivary glands
• thickening of bronchial secretions
• tightness in chest
• trembling
• troubled breathing
• unpleasant breath odor
• unusual bleeding or bruising
• unusual tiredness or weakness
• unusual weight loss
• vomiting of blood
• weakness and heaviness of legs
• weight gain
• wheezing
• yellow eyes or skin

Other side effects of methyclothiazide

Some side effects of methyclothiazide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

• cramping
• decreased interest in sexual intercourse
• difficulty having a bowel movement (stool)
• feeling of constant movement of self or surroundings
• hair loss, thinning of hair
• inability to have or keep an erection
• increased sensitivity of skin to sunlight
• loss in sexual ability, desire, drive, or performance
• muscle spasm
• pinpoint red or purple spots on skin
• redness or other discoloration of skin
• restlessness
• sensation of spinning
• severe sunburn
• weakness

For healthcare professionals

Applies to methyclothiazide: compounding powder, oral tablet.

Gastrointestinal

• Frequency not reported: Pancreatitis, sialadenitis, vomiting, diarrhea, nausea, gastric irritation, constipation^[Ref]

Dermatologic

• Frequency not reported: Cutaneous vasculitis, purpura, urticaria, rash, photosensitivity^[Ref]

Hematologic

• Frequency not reported: Aplastic anemia, hemolytic anemia, agranulocytosis, leukopenia, thrombocytopenia^[Ref]

Metabolic

• Frequency not reported: Anorexia, hyperglycemia, hyperuricemia, electrolyte imbalance, hypercalcemia^[Ref]

Nervous system

• Frequency not reported: Headache, vertigo, dizziness, paresthesias^[Ref]

Respiratory

• Frequency not reported: Respiratory distress, pneumonitis, pulmonary edema^[Ref]

Cardiovascular

• Frequency not reported: Orthostatic hypotension, vasculitis^[Ref]

Immunologic

• Frequency not reported: Anaphylactic reaction, Stevens-Johnson syndrome^[Ref]

Musculoskeletal

• Frequency not reported: Cramping, muscle spasm^[Ref]

Ocular

• Frequency not reported: Transient blurred vision, xanthopsia^[Ref]

Other

• Frequency not reported: Weakness, fever^[Ref]

Genitourinary

• Frequency not reported: Glycosuria^[Ref]

Hepatic

• Frequency not reported: Intrahepatic cholestatic jaundice^[Ref]

Psychiatric

• Frequency not reported: Restlessness^[Ref]

Further information

Methyclothiazide side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer