Applies to the following strengths: 5 mg; 2.5 mg
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Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Hypertension
2.5 to 5 mg orally once a day
Comments: If blood pressure remains uncontrolled after 8 to 12 weeks at 5 mg once a day, another antihypertensive drug should be added.
Uses: Treatment of mild to moderate hypertension as monotherapy; treatment of more severe hypertension when used concomitantly with other antihypertensive drugs.
Usual Adult Dose for Edema
2.5 to 10 mg orally once a day
Maximum dose: 10 mg
Uses: Adjunctive treatment of edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy; this drug has also been useful in edema due to various forms of renal dysfunction (e.g., nephrotic syndrome, acute glomerulonephritis, and chronic renal failure).
Renal Dose Adjustments
Use with caution
If progressive renal impairment becomes evident as indicated by a rising BUN or nonprotein nitrogen: Consider withholding or discontinuing this drug
Liver Dose Adjustments
Use with caution
Safety and efficacy have not been established in patients younger than 18 years.
Consult WARNINGS section for additional precautions.
Data not available
Storage requirements: Protect from light.
-Metabolic: Serum electrolytes periodically.
Patient advice: Advise patients to report any of the following symptoms of electrolyte imbalance: dry mouth, thirst, weakness, tiredness, drowsiness, restlessness, muscle pains or cramps, nausea, vomiting, or increased heart rate.
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- Drug class: thiazide diuretics