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Methyclothiazide Dosage

Applies to the following strengths: 5 mg; 2.5 mg

Usual Adult Dose for Hypertension

2.5 to 5 mg orally once a day

Comments: If blood pressure remains uncontrolled after 8 to 12 weeks at 5 mg once a day, another antihypertensive drug should be added.

Uses: Treatment of mild to moderate hypertension as monotherapy; treatment of more severe hypertension when used concomitantly with other antihypertensive drugs.

Usual Adult Dose for Edema

2.5 to 10 mg orally once a day

Maximum dose: 10 mg

Uses: Adjunctive treatment of edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy; this drug has also been useful in edema due to various forms of renal dysfunction (e.g., nephrotic syndrome, acute glomerulonephritis, and chronic renal failure).

Renal Dose Adjustments

Use with caution

If progressive renal impairment becomes evident as indicated by a rising BUN or nonprotein nitrogen: Consider withholding or discontinuing this drug

Liver Dose Adjustments

Use with caution


Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.


Data not available

Other Comments

Storage requirements: Protect from light.


Patient advice: Advise patients to report any of the following symptoms of electrolyte imbalance: dry mouth, thirst, weakness, tiredness, drowsiness, restlessness, muscle pains or cramps, nausea, vomiting, or increased heart rate.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.