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Lopid Side Effects

Generic name: gemfibrozil

Medically reviewed by Last updated on Jul 26, 2021.

Note: This document contains side effect information about gemfibrozil. Some of the dosage forms listed on this page may not apply to the brand name Lopid.


Common side effects of Lopid include: malignant neoplasm, pancreatitis, dyspepsia, and cholelithiasis. Other side effects include: abdominal pain. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to gemfibrozil: oral tablets

Side effects include:

GI disturbances (e.g., dyspepsia, abdominal pain, diarrhea, nausea, vomiting, constipation, acute appendicitis, gallbladder surgery), adverse CNS effects (headache, hypesthesia, paresthesias, dizziness, somnolence, peripheral neuritis, depression), fatigue, eczema, vertigo, taste perversion, blurred vision, decreased libido, impotence.

For Healthcare Professionals

Applies to gemfibrozil: compounding powder, oral tablet


The most frequently reported side effects were gastrointestinal reactions and included dyspepsia, abdominal pain, diarrhea, nausea, vomiting, acute appendicitis, constipation, and flatulence.[Ref]


Very common (10% or more): Dyspepsia (19.6%)

Common (1% to 10%): Abdominal pain, acute appendicitis, diarrhea, nausea, vomiting, constipation, flatulence

Rare (less than 0.1%): Pancreatitis

Frequency not reported: Colitis[Ref]

Nervous system

Common (1% to 10%): Headache

Rare (less than 0.1%): Peripheral neuropathy, paresthesia, dizziness, somnolence

Frequency not reported: Peripheral neuritis, convulsions, syncope, hyperesthesia, taste perversion, intracerebral hemorrhage[Ref]


Rare (less than 0.1%): Hepatitis, cholestatic jaundice, cholelithiasis, cholecystitis, hepatic function abnormal

Frequency not reported: ALT increased, AST increased, bilirubin increased, alkaline phosphatase increased[Ref]


Uncommon (0.1% to 1%): Atrial fibrillation

Frequency not reported: Extrasystoles, vasculitis, peripheral vascular disease[Ref]


Common (1% to 10%): Eczema, rash

Rare (less than 0.1%): Angioedema, urticaria, exfoliative dermatitis, dermatitis, pruritus, alopecia, photosensitivity reaction[Ref]


Common (1% to 10%): Fatigue, vertigo

Rare (less than 0.1%): Creatine phosphokinase increased

Frequency not reported: Weight loss, viral infections, bacterial infections[Ref]


Rare (less than 0.1%): Myopathy, myalgia, painful extremities, arthralgia, synovitis, rhabdomyolysis, myositis, muscular weakness

Frequency not reported: Lupus-like syndrome, myasthenia[Ref]


Rare (less than 0.1%): Bone marrow failure, severe anemia, thrombocytopenia, leukopenia, eosinophilia, hemoglobin decreased, hematocrit decreased, WBC decreased

Frequency not reported: Anemia, bone marrow hypoplasia[Ref]


Rare (less than 0.1%): Blurred vision

Frequency not reported: Retinal edema, cataracts[Ref]


Rare (less than 0.1%): Erectile dysfunction

Frequency not reported: Impotence, male fertility decreased[Ref]


Rare (less than 0.1%): Libido decreased, depression

Frequency not reported: Confusion[Ref]


Rare (less than 0.1%): Laryngeal edema[Ref]


Frequency not reported: Renal dysfunction, renal failure[Ref]


Frequency not reported: Hepatoma[Ref]


Frequency not reported: Positive antinuclear antibody, anaphylaxis[Ref]


1. "Product Information. Lopid (gemfibrozil)." Parke-Davis (2002):

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. Cerner Multum, Inc. "Australian Product Information." O 0

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.