Jardiance Side Effects

Generic name: empagliflozin

Medically reviewed by Philip Thornton, DipPharm. Last updated on Nov 13, 2023.

Note: This document provides detailed information about Jardiance Side Effects associated with empagliflozin. Some dosage forms listed on this page may not apply specifically to the brand name Jardiance.

Applies to empagliflozin: oral tablet.

Serious side effects of Jardiance

Along with its needed effects, empagliflozin (the active ingredient contained in Jardiance) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking empagliflozin:

Other side effects of Jardiance

Some side effects of empagliflozin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to empagliflozin: oral tablet.

General adverse events

The most common adverse reactions (incidence of greater than 5%) were urinary tract infections, female genital mycotic infections, hypoglycemia, and adverse reactions related to volume depletion. Pediatric patients experienced a higher incidence of hypoglycemia.^[Ref]

Cardiovascular

• Postmarketing reports: Hypotension

Dermatologic

• Common (1% to 10%): Pruritus, rash
• Postmarketing reports: Skin reactions including angioedema and urticaria

Gastrointestinal

• Common (1% to 10%): Nausea
• Postmarketing reports: Constipation

Genitourinary

• Very common (10% or more): Female urinary tract infections (up to 18.4%)
• Common (1% to 10%): Female genital mycotic infections, increased urination, male urinary tract infections
• Uncommon (0.1% to 1%): Phimosis, male genital mycotic infections, nocturia, dysuria
• Postmarketing reports: Urosepsis, pyelonephritis, necrotizing fasciitis of the perineum (Fournier's gangrene)

Hematologic

• Common (1% to 10%): Increased hematocrit

Hepatic

• Frequency not reported: Hepatic injury

Hypersensitivity

• Postmarketing reports: Angioedema, hypersensitivity reactions

Metabolic

• Very common (10% or more): Hypoglycemia, especially in combination with other glucose lowering therapies (up to 41.3%), adverse reactions related to volume depletion (up to 11.4%)
• Common (1% to 10%): Increased low-density lipoprotein cholesterol, dyslipidemia
• Postmarketing reports: Ketoacidosis

The risk of hypoglycemia (i.e., blood glucose less than 54 mg/dL) was higher in pediatric patients.

Reactions related to volume depletion included decreased ambulatory blood pressure, decreased systolic blood pressure, dehydration, hypotension, hypovolemia, orthostatic hypotension, and syncope with the highest rates occurring in patients with heart failure.

In clinical studies, ketoacidosis was not immediately recognized, especially in patients with type 1 diabetes, and treatment was delayed because presenting blood glucose levels were lower (often less than 250 mg/dL [14 mmol/l]) than those typically expected. In some, but not all cases, patients had an identifiable precipitating risk factor for ketoacidosis

Musculoskeletal

• Common (1% to 10%): Arthralgia

Other

• Common (1% to 10%): Thirst
• Frequency not reported: Lower limb amputation

Renal

• Very rare (less than 0.01%): Tubulo-interstitial nephritis
• Frequency not reported: Increased serum creatinine, decreased estimated GFR
• Postmarketing reports: Acute kidney injury, urosepsis, pyelonephritis

Respiratory

• Common (1% to 10%): Upper respiratory tract infection

Frequently asked questions

• How to avoid yeast infections on Jardiance?
• Does Jardiance cause weight loss?
• How long does it take for Jardiance to work?
• What does Jardiance do to your perineum?
• What is Jardiance used for and how does it work?
• Can Jardiance cause kidney problems?
• How does Jardiance help with heart failure?
• When is the best time of day to take Jardiance?

Further information

Jardiance side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer