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Does Jardiance cause weight loss?

Medically reviewed by Leigh Ann Anderson, PharmD Last updated on May 21, 2020.

Official Answer

by Drugs.com

Key Points

  • Yes, Jardiance (generic name: empagliflozin) can help patients with type 2 diabetes lose weight. In 24-week clinical studies, weight loss with Jardiance treatment alone was found to be statistically significant and ranged between a 2% and 3% weight loss.
  • Jardiance is not FDA approved to be used for weight loss in patients without type 2 diabetes.
  • In clinical trials, Jardiance also led to statistically significant reductions in A1C and fasting plasma glucose, measures of blood sugar control, when compared to an inactive placebo. Jardiance is classified as an SGLT-2 inhibitors and carries a low risk of hypoglycemia (low blood sugar).

In studies, patients taking the 10 mg dose of Jardiance had an average weight loss of 2.8% from their baseline weight (their weight at the start of the study). Those receiving the 25 mg tablet had an average weight loss of 3.2% of their baseline weight. The group who received an inactive placebo had a weight loss of 0.4%.

  • As an example, in a 200 lb (91 kg) person, a 2.8% loss weight with the 10 mg dose is equal to roughly 5.6 lbs (2.6 kg).
  • A 3.2% weight loss in a 200 lb (91 kg) person taking the 25 mg dose is about a 6.4 lb (2.9 kg) weight loss.

What is Jardiance approved for?

Jardiance is used to help control glucose (blood sugar) in adult patients with type 2 diabetes. Jardiance is also FDA-approved to lower the risk of cardiovascular (heart-related) death in adults with heart disease and type 2 diabetes. Jardiance is an oral tablet taken once-a-day and is used in addition to diet and exercise.

Jardiance can be added to other medicines for type 2 diabetes such as metformin, sulfonylureas, pioglitazone, and insulin as well as other heart medications like statins, beta blockers, ACE inhibitors, and diuretics. Jardiance, classified as a sodium-glucose cotransporter-2 (SGLT-2) inhibitor, is manufactured by Boehringer Ingelheim Pharmaceuticals and Eli Lilly.

Will I still lose weight if I take Jardiance with metformin?

Yes, you may achieve weight loss if you are taking metformin in combination with Jardiance, too. In a 24-week long clinical study with over 600 patients, Jardiance given as add-on therapy to metformin significantly improved weight. These patients were not adequately controlled on metformin alone.

Table 1. Weight changes for Jardiance when used with metformin

  Jardiance 10 mg + metformin Jardiance 25 mg + metformin Placebo + metformin
Baseline weight 82 kg (180.4 lbs) 82 kg (180.4 lbs) 80 kg (176 lbs)
% change from baseline (mean) -2.5% -2.9% -0.5%
Difference from placebo (mean) -2.0 (95% CI; -2.6, -1.4) -2.5 (95% CI; -3.1, -1.9)  n/a

Weight loss was also significant when Jardiance was used with metformin and a sulfonylureas in a study over 24-weeks long.

How does Jardiance affect my blood pressure?

Jardiance is not specifically FDA-approved to reduce blood pressure, but a positive effect was seen in clinical trials. Blood pressure was lowered whether Jardiance was used alone (as monotherapy) or with metformin.

  • When used alone, the systolic blood pressure (the top number) was statistically significantly reduced compared to placebo by -2.6 mmHg in patients taking the 10 mg dose of Jardiance.
  • In patients taking the 25 mg dose of Jardiance, systolic blood pressure was reduced by -3.4 mmHg.

Important side effects with Jardiance

Jardiance is usually well-tolerated in patients with type 2 diabetes. However, as with all drugs, there are important side effects you should review with your doctor.

Serious side effects:

  • allergic reactions
  • dehydration
  • increased cholesterol levels
  • ketoacidosis (increased ketones in your blood or urine)
  • low blood sugar (hypoglycemia)
  • necrotizing fasciitis (a rare, serious tissue infection around the anus and genitals)
  • sudden kidney injury
  • urinary tract infections
  • increased cholesterol

Common side effects (5% or more of patients):

  • urinary tract infections
  • yeast infections

Bottom Line

  • Jardiance can lead to moderate weight loss in patients when taken alone, or when combined with other medications, including metformin or a sulfonylureas. Overall, patients could lose 2% to 3% of their weight, although this is variable and can be affected by many factors, such as diet and exercise.
  • Jardiance can also have positive effects on your heart (cardiovascular) outcomes and lower your risk for a heart-related death. Positive effects on blood pressure, kidney health, weight goals, and risks for hypoglycemia (low blood sugar) may also be seen.
  • Overall, Jardiance is a well-tolerated, once daily oral treatment for type 2 diabetes, often used as an add-on treatment to metformin. However, common side effects can occur, including genital yeast infections and urinary tract infections. Be sure to discuss all possible side effects with your doctor.

This is not all the information you need to know about Jardiance for safe and effective use. Review the full Jardiance information here, and speak to your health care provider if you have questions or concerns.

References
  • Häring HU, Merker L, Seewaldt-Becker E, et al. Empagliflozin as add-on to metformin in patients with type 2 diabetes: a 24-week, randomized, double-blind, placebo-controlled trial. Diabetes Care 2014;37:1650-1659

  • Tikkanen I, Narko K, Zeller C, et al. Empagliflozin reduces blood pressure in patients with type 2 diabetes and hypertension. Diabetes Care 2015;38:420-428.

  • Pharmacologic Approaches to Glycemic Treatment: Standards of Medical Care in Diabetes 2020. American Diabetes Association. Diabetes Care 2020 Jan; 43(Supplement 1): S98-S110. https://doi.org/10.2337/dc20-S009

  • Jardiance [package insert].  Boehringer Ingelheim Pharmaceuticals, Inc.; Ridgefield, CT Accessed May 20, 2020 at https://docs.boehringer-ingelheim.com/Prescribing%20Information/PIs/Jardiance/jardiance.pdf

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