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Indapamide Side Effects

Medically reviewed by Last updated on Mar 15, 2023.

Applies to indapamide: oral tablet.

Serious side effects of Indapamide

Along with its needed effects, indapamide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking indapamide:

More common

Less common

Incidence not known

Other side effects of Indapamide

Some side effects of indapamide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

For Healthcare Professionals

Applies to indapamide: compounding powder, oral tablet.


Most adverse side effects are mild and transient.[Ref]


Dermatologic reactions, such as rashes, occur in less than 5% of patients, and comprise up to 36% of all adverse drug reactions associated with indapamide.[Ref]


Metabolic abnormalities are common, but are rarely clinically significant. Hypokalemia occurs in 15% of patients, although clinically relevant hypokalemia is reported in only 1% and 3% of patients receiving 2.5 and 5.0 mg/day, respectively. Hyponatremia, hyperglycemia, and hyperuricemia are reported in 1% to 5% of patients but are rarely clinically relevant. Unlike the thiazides, indapamide has little or no adverse effect on the lipid profile. Severe cases of hyponatremia, accompanied by hypokalemia have been reported with recommended doses of indapamide in elderly females.[Ref]


Renal side effects are unusual, consisting primarily of azotemia.[Ref]

A case of interstitial nephritis and an urticarial rash associated with indapamide has been reported.[Ref]


Gastrointestinal side effects include dyspepsia, constipation, diarrhea, flatulence, and dry mouth in less than 5% of patients.[Ref]

Nervous system

Nervous system side effects include dizziness, lightheadedness, headache, and fatigue in 5% of patients.[Ref]


Cardiovascular side effects are usually limited to postural hypotension. Indapamide does not affect the heart rate.[Ref]


Musculoskeletal cramps are reported in about 5% of patients. A single case of skeletal muscle damage has been associated with indapamide.[Ref]

A 71-year-old woman with a history of psychiatric problems and reflux esophagitis developed chest pain, finger numbness, sweating, and nausea while gardening. Her medications included indapamide, trifluoperazine, oxazepam, and ranitidine. Myocardial infarction was definitively ruled out by ECG and CPK isoenzyme analysis. Interesting laboratory values included a reduced serum sodium (117 mmol/L), elevated LDH and AST enzymes, and elevated CPK-MM isoenzymes. There was no history of muscular trauma, and thyroid function tests were normal. The hyponatremia and elevated CPK-MM fractions fell precipitously upon hydration with normal saline. A definite causal link between indapamide and rhabdomyolysis could not be made, but thiazide diuretics have been previously implicated in some cases of hypokalemia with subsequent muscle damage.[Ref]


Decreased sexual libido is rare, with up to 88% of patients reporting no change and most of the remaining 12% reporting improvement of sexual libido during indapamide therapy.[Ref]

Genitourinary side effects generally reflect the activity of the drug, with less than 5% of patients reporting polyuria and nocturia.[Ref]


Hepatic side effects are rare, at least one case of hepatitis has been reported.[Ref]

A case of reversible hepatitis associated with indapamide has been reported.[Ref]


Hypersensitivity reactions occur in less than 5% of patients. Cases of severe reactions including toxic epidermal necrolysis, erythema multiforme, and Stevens-Johnson syndrome have been reported. Patients with a sulfa allergy may react to indapamide.[Ref]


Endocrine side effects include at least one case of indapamide-induced hyperparathyroidism. In one study, indapamide significantly reduced parathyroid hormone levels in all patients.[Ref]


Hematologic side effects are rare, but have included at least one case of mild thrombocytopenia and mucosal bleeding from the tongue. Bleeding stopped promptly and platelet counts returned to normal following discontinuation of indapamide.[Ref]


1. Multum Information Services, Inc. Expert Review Panel

2. Slotkoff L. Clinical efficacy and safety of indapamide in the treatment of edema. Am Heart J. 1983;106:233-7.

3. Partanen J, Pohjola-Sintonen S, Makijarvi M, Harma M. Toxic epidermal necrolysis due to indapamide. Arch Dermatol. 1993;129:793.

4. Black RJ, Murphy P, Robinson TJ, Scott KW. Toxic epidermal necrolysis associated with indapamide. BMJ. 1990;301:1280-1.

5. Newstead CG, Moore RH, Barnes AJ. Interstitial nephritis associated with indapamide. BMJ. 1990;300:1344.

6. Stricker BH, Biriell C. Skin reactions and fever with indapamide. Br Med J (Clin Res Ed). 1987;295:1313-4.

7. Spinler SA, Globus NJ, Raymond JZ, Lancefield ML. Indapamide-associated Stevens-Johnson syndrome. Cutis. 1992;50:200-2.

8. Gales BJ, Gales MA. Erythema multiforme and angioedema with indapamide and sertraline. Am J Hosp Pharm. 1994;51:118-9.

9. Anavekar SN, Ludbrooke A, Louis WJ, Doyle AE. Evaluation of indapamide in the treatment of hypertension. J Cardiovasc Pharmacol. 1979;1:389-94.

10. Mroczek WJ. Indapamide: clinical pharmacology, therapeutic efficacy in hypertension, and adverse effects. Pharmacotherapy. 1983;3:61-7.

11. Beling S, Vukovich RA, Neiss ES, Zisblatt M, Webb E, Losi M. Long-term experience with indapamide. Am Heart J. 1983;106:258-62.

12. Leonetti G, Rappelli A, Salvetti A, Scapellato L. Long-term effects of indapamide: final results of a two-year Italian multicenter study in systemic hypertension. Am J Cardiol. 1990;65:h67-71.

13. Boulton AJ, Hardisty CA. Ventricular arrhythmias precipitated by treatment with non-thiazide diuretics. Practitioner. 1982;226:125-8.

14. Chan TY. Indapamide-induced severe hyponatremia and hypokalemia. Ann Pharmacother. 1995;29:1124-8.

15. Ames RP. A comparison of blood lipid and blood pressure responses during the treatment of systemic hypertension with indapamide and with thiazides. Am J Cardiol. 1996;77:b12-6.

16. Pickkers P, Schachter M, Hughes AD, Feher MD, Sever PS. Thiazide-induced hyperglycaemia: a role for calcium-activated potassium channels? Diabetologia. 1996;39:861-4.

17. Flack JR, Molyneaux L, Willey K, Yue DK. Regression of microalbuminuria - results of a controlled study, indapamide versus captopril. J Cardiovasc Pharmacol. 1993;22:S75-7.

18. Brennan L, Wu MJ, Laquer UJ. A multicenter study of indapamide in hypertensive patients with impaired renal function. Clin Ther. 1982;5:121-8.

19. Chaffman M, Heel RC, Brogden RN, Speight TM, Avery GS. Indapamide. A review of its pharmacodynamic properties and therapeutic efficacy in hypertension. Drugs. 1984;28:189-235.

20. Bowker CH, Murphy MA. A multicentre open trial indapamide in general practice. Postgrad Med J. 1981;57:53-6.

21. Eff J, Bratnick J, Zisblatt M, Vukovich RA, Neiss E. Indapamide, a new antihypertensive/diuretic agent, in the treatment of patients with edema. Clin Ther. 1984;6:778-86.

22. Indapamide (Lozol)--A new antihypertensive agent and diuretic. Med Lett Drugs Ther. 1984;26:17-8.

23. Read SJ, Trenerry HM, Whiting GF. Hyponatraemia and raised creatine kinase level associated with indapamide. Med J Aust. 1994;161:607-8.

24. Product Information. Lozol (indapamide). Rhone Poulenc Rorer. 2002.

25. Ceylan K, Topal C, Erkoc R, et al. Effect of indapamide on urinary calcium excretion in patients with and without urinary stone disease. Ann Pharmacother. 2005;39:1034-8.

26. Debono M, Banerjee R. Indapamide-induced hyperparathyroidism: a case report. Eur J Clin Pharmacol. 2007.

27. Hasanova EA, Agasiyeva NE. Bleeding associated with indapamide SR therapy. Ann Pharmacother. 2004;38:199-200.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.