Generic name: indapamide [ in-DAP-a-mide ]
Drug class: Thiazide diuretics
Medically reviewed by Drugs.com. Last updated on Jul 26, 2023.
Uses for indapamide
Indapamide is used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.
Indapamide is also used to treat salt and fluid retention (edema) caused by congestive heart failure.
Indapamide is a thiazide-like diuretic (water pill). It reduces the amount of water in the body by increasing the flow of urine, which helps lower the blood pressure.
This medicine is available only with your doctor's prescription.
Before using indapamide
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies have not been performed on the relationship of age to the effects of indapamide in the pediatric population. Safety and efficacy have not been established.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of indapamide in the elderly. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require an adjustment in the dose for patients receiving indapamide.
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with Medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Amtolmetin Guacil
- Arsenic Trioxide
- Choline Salicylate
- Flufenamic Acid
- Insulin Aspart, Recombinant
- Insulin Bovine
- Insulin Degludec
- Insulin Detemir
- Insulin Glulisine
- Mefenamic Acid
- Niflumic Acid
- Nimesulide Beta Cyclodextrin
- Salicylic Acid
- Sodium Salicylate
- Tiaprofenic Acid
- Tolfenamic Acid
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Aminolevulinic Acid
Interactions with Food/Tobacco/Alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
- Anuria (not able to form urine) or
- Sulfa drug allergy—Should not be used in patients with these conditions.
- Diabetes or
- Electrolyte imbalance (eg, high calcium or low magnesium, potassium, sodium in the body) or
- Glaucoma, angle-closure or
- Gout or
- Heart rhythm problems or
- Hyperglycemia (high blood sugar) or
- Hyperuricemia (high uric acid in the blood) or
- Liver disease or
- Myopia (nearsightedness) or
- Systemic lupus erythematosus (SLE)—Use with caution. May make these conditions worse.
- Kidney disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
- Sympathectomy (a surgical procedure where certain nerves are removed)—Use with caution. The effects of this medicine may be increased.
Proper use of indapamide
In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium (salt) or potassium. Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.
Many patients who have high blood pressure will not notice any signs of the problem. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.
Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to receive it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.
The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
- For oral dosage form (tablets):
- For fluid retention (edema):
- Adults—At first, 2.5 milligrams (mg) once a day, taken in the morning. Your doctor may adjust your dose as needed. However, the dose is usually not more than 5 mg.
- Children—Use and dose must be determined by your doctor.
- For high blood pressure:
- Adults—At first, 1.25 milligrams (mg) once a day, taken in the morning. Your doctor may adjust your dose as needed. However, the dose is usually not more than 5 mg.
- Children—Use and dose must be determined by your doctor.
- For fluid retention (edema):
If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Ask your healthcare professional how you should dispose of any medicine you do not use.
Precautions while using indapamide
It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.
Check with your doctor right away if you have confusion, decreased urine, dizziness, drowsiness, dry mouth, increased thirst, fast or irregular heartbeat or pulse, headache, muscle pains or cramps, nausea or vomiting, seizures, swelling of the face, ankles, or hands, trouble breathing, or unusual tiredness or weakness. These may be symptoms of an electrolyte imbalance (eg, low sodium or potassium in the blood).
This medicine may cause changes in your blood sugar levels. Check with your doctor if you have these problems or if you notice a change in the results of your blood or urine sugar tests.
Check with your doctor right away if you have blurred vision, difficulty in reading, eye pain, or any other change in vision during or after treatment. This could be a sign of a serious eye problem. Your doctor will want you to have your eyes checked by an ophthalmologist (eye doctor).
Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery or medical tests.
Do not take other medicines unless they have been discussed with your doctor. This especially includes prescription or nonprescription (over-the-counter) medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems, since they may increase your blood pressure.
Side Effects of indapamide
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
- black, tarry stools
- chest pain
- cough or hoarseness
- dark urine
- fever or chills
- light-colored stools
- lower back or side pain
- muscle cramps or spasms
- painful or difficult urination
- sore throat
- sores, ulcers, or white spots in the mouth or on the lips
- stuffy or runny nose
- swollen glands
- unusual bleeding or bruising
- unusual tiredness or weakness
- yellow eyes and skin
- Blurred vision
- body aches or pain
- burning, dry, or itching eyes
- change in consciousness
- cold sweats
- decreased urine output
- discharge, excessive tearing
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- dry mouth
- dryness or soreness of the throat
- excessive muscle tone
- fast, irregular, pounding, or racing heartbeat or pulse
- feeling sad or empty
- flushed, dry skin
- frequent urination
- fruit-like breath odor
- increased hunger, thirst, and urination
- increased urge to urinate during the night
- increased volume of pale, dilute urine
- joint pain, stiffness, or swelling
- lack of appetite
- loss of interest or pleasure
- lower back, side, or stomach pain
- mood changes
- muscle pain, cramps, tension, stiffness, or tightness
- pain or tenderness around the eyes and cheekbones
- redness, pain, swelling of the eye, eyelid, or inner lining of eyelid
- sugar in the urine
- swelling of the face, feet, lower legs, ankles, or hands
- tender, swollen glands in the neck
- tightness in the chest
- trouble breathing
- trouble concentrating
- trouble in swallowing
- trouble sleeping
- voice changes
- waking to urinate at night
Incidence not known
- Change in near or distance vision
- difficulty in focusing the eyes
- eye pain
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Back pain
- blistering, peeling, loosening of the skin
- increased sensitivity of skin to sunlight
- red irritated eyes
- red skin lesions, often with a purple center
- redness or other discoloration of the skin
- severe sunburn
- Acid or sour stomach
- bloating or swelling of the face, arms, hands, lower legs, or feet
- decreased interest in sexual intercourse
- hives or rash
- inability to have or keep an erection
- lack or loss of strength
- loss in sexual ability, desire, drive, or performance
- rapid weight gain
- stomach discomfort or upset
- tingling of the hands or feet
- unusual weight gain or loss
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
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